Cimiracemoside F

CAS# 264875-61-8

Cimiracemoside F

Catalog No. BCN0045----Order now to get a substantial discount!

Product Name & Size Price Stock
Cimiracemoside F: 5mg Please Inquire In Stock
Cimiracemoside F: 10mg Please Inquire In Stock
Cimiracemoside F: 20mg Please Inquire Please Inquire
Cimiracemoside F: 50mg Please Inquire Please Inquire
Cimiracemoside F: 100mg Please Inquire Please Inquire
Cimiracemoside F: 200mg Please Inquire Please Inquire
Cimiracemoside F: 500mg Please Inquire Please Inquire
Cimiracemoside F: 1000mg Please Inquire Please Inquire

Quality Control of Cimiracemoside F

Number of papers citing our products

Chemical structure

Cimiracemoside F

Chemical Properties of Cimiracemoside F

Cas No. 264875-61-8 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C37H56O11 M.Wt 676.9
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cimiracemoside F

The roots of Cimicifuga foetida L.

Biological Activity of Cimiracemoside F

DescriptionCimiracemoside F has anti-stress effects.

Cimiracemoside F Dilution Calculator

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Cimiracemoside F Molarity Calculator

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Preparing Stock Solutions of Cimiracemoside F

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4773 mL 7.3866 mL 14.7732 mL 29.5465 mL 36.9331 mL
5 mM 0.2955 mL 1.4773 mL 2.9546 mL 5.9093 mL 7.3866 mL
10 mM 0.1477 mL 0.7387 mL 1.4773 mL 2.9546 mL 3.6933 mL
50 mM 0.0295 mL 0.1477 mL 0.2955 mL 0.5909 mL 0.7387 mL
100 mM 0.0148 mL 0.0739 mL 0.1477 mL 0.2955 mL 0.3693 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cimiracemoside F

Oral administration of Cimicifuga racemosa extract attenuates immobilization stress-induced reactions.[Pubmed:22428232]

Nat Prod Commun. 2012 Jan;7(1):15-8.

Dried rhizomes of Cimicifuga racemosa (CR), known as black cohosh, have been widely used as a herbal dietary supplement in the treatment of menopausal symptoms. Here we used experimental mouse stress models to investigate the role of anti-stress food factors, and found that a CR extract had stress-relieving effects. A single oral administration of CR extract (1,000 mg/kg) significantly attenuated plasma corticosterone and aspartate aminotransferase (AST) levels that had increased as a result of enforced immobilization. Bioassay-guided fractionation of the CR extract resulted in the isolation of 10 triterpenes, among which actein, 23-epi-26-deoxyactein, and Cimiracemoside F (100 mg/kg, per os) were shown to contribute to the anti-stress effects. Furthermore, the CR extract significantly prevented the development of water immersion stress-induced gastric mucosal ulcers in rats. We propose that the CR extract might be suitable for the prevention and treatment of stress-related disorders.

Phytochemical fingerprinting to thwart black cohosh adulteration: a 15 Actaea species analysis.[Pubmed:21337649]

Phytochem Anal. 2011 Jul-Aug;22(4):339-51.

INTRODUCTION: The popular use of black cohosh products (Actaea racemosa L., syn. Cimicifuga racemosa L.) is growing as the demand for alternatives to estrogen therapy has increased. Critical to safe use is the assurance of unadulterated, high-quality products. Questions have been raised about the safety of black cohosh due to cases of liver toxicity in patients who reported taking it; subsequent evaluation found some products to be adulterated with other related herbal species. Correct plant species identification is a key first step for good manufacturing practices of safe black cohosh products. OBJECTIVES: To develop analytical methods which distinguish black cohosh from other species (American and Asian) of Actaea increasingly found as adulterants in commercially available black cohosh products. MATERIAL AND METHODS: Fifteen species of Actaea were collected from North America and Asia, and the phytochemical fingerprints of these samples were established using HPLC-PDA and LC-MS techniques. RESULTS: The HPLC and LC-MS fingerprints for polyphenols and triterpene glycosides revealed distinct patterns that make black cohosh clearly distinguishable from most other species of Actaea. Two marker compounds, cimifugin and Cimiracemoside F, were found to be important to distinguish black cohosh from most Asian species of Actaea. Formononetin was not found from either Asian or American species of Actaea. CONCLUSIONS: Phytochemical fingerprinting is a practical, reliable method for authenticating black cohosh and distinguishing it from other species of Actaea increasingly found as adulterants in commercially available black cohosh products. This should facilitate the continued development of high-quality, unadulterated black cohosh products.

Evaluation of triterpene glycoside estrogenic activity using LC/MS and immunoaffinity extraction.[Pubmed:11605850]

Anal Chem. 2001 Oct 1;73(19):4704-10.

We present a study on the mass spectral as well as the binding properties of three triterpene glycosides (cimicifugoside, Cimiracemoside F, 27-deoxyactein) contained in black cohosh to the ligand binding domain of estrogen receptor beta (ER-beta). Using affinity ultrafiltration and LC/ MS detection, initial experiments using estradiol and the phytoestrogens daidzein and genistein (compounds known to bind ER-beta) were performed to serve as positive controls. The same affinity techniques and LC/MS procedures were then employed to show that neither the triterpene glycosides nor their enzymatically prepared aglycons bound significantly to ER-beta, except for 27-deoxyactein aglycon, which showed weak binding affinity (4%). Additionally, metabolites of the aglycons were prepared by incubation with female human liver microsomes and subjected to binding experiments with ER-beta. No significant binding of the metabolites to the receptor was observed. Further studies are needed to fully characterize whether these triterpene glycosides as well as other components of black cohosh in this plant extract bind to the estrogen receptor alpha (ER-alpha).

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