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Aristolochic acid D

CAS# 17413-38-6

Aristolochic acid D

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Aristolochic acid D: 5mg $104 In Stock
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Chemical structure

Aristolochic acid D

3D structure

Chemical Properties of Aristolochic acid D

Cas No. 17413-38-6 SDF Download SDF
PubChem ID 161218 Appearance Orange-red powder
Formula C17H11NO8 M.Wt 357.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Synonyms Aristolochic acid Iva
Solubility Soluble in DMSO; sparingly soluble in water
Chemical Name 10-hydroxy-8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
SMILES COC1=CC(=CC2=C3C(=C(C=C12)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O)O
Standard InChIKey PADIFGYTAXNCRK-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aristolochic acid D

The herbs of Aristolochia debilis Sieb. et Zucc

Biological Activity of Aristolochic acid D

Description1. Chinese-herb nephropathy (CHN) is a rapidly progressive renal fibrosis associated with the intake of a Chinese herb (Aristolochia fangchi) containing nephrotoxic and carcinogenic aristolochic acids .

Aristolochic acid D Dilution Calculator

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Aristolochic acid D Molarity Calculator

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Preparing Stock Solutions of Aristolochic acid D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7988 mL 13.9938 mL 27.9877 mL 55.9754 mL 69.9692 mL
5 mM 0.5598 mL 2.7988 mL 5.5975 mL 11.1951 mL 13.9938 mL
10 mM 0.2799 mL 1.3994 mL 2.7988 mL 5.5975 mL 6.9969 mL
50 mM 0.056 mL 0.2799 mL 0.5598 mL 1.1195 mL 1.3994 mL
100 mM 0.028 mL 0.1399 mL 0.2799 mL 0.5598 mL 0.6997 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aristolochic acid D

6-O-beta-D-glucoside of aristolochic acid IIIa and other components from the roots of Aristolochia baetica.[Pubmed:17252385]

Planta Med. 1997 Dec;63(6):579.

From the root extract of the European Aristolochia baetica L. we isolated aristolochic acid IIIa-6-O-beta-D-glucoside (1) besides magnoflorine chloride, the free aristolochic acids I and II, and five aristolactams. Saccharose and fructose were found as major constituents.

Urinary d-lactate levels reflect renal function in aristolochic acid-induced nephropathy in mice.[Pubmed:23553367]

Biomed Chromatogr. 2013 Sep;27(9):1100-6.

Urinary d-lactate is highly correlated to diabetic nephropathy - a progressive kidney disease in renal glomeruli. In this study, we used a C3H/3e mouse model to investigate the relationship between urinary d-lactate and aristolochic acid nephropathy where the glomerular structure is not affected. The nephropathy was induced using intravenous injections of aristolochic acid at a dosage of 10 mg/kg per day for 5 days and was characterized biochemically and histologically. The urinary excretions of proteins, N-acetyl-beta-d-glucosaminidase and serum creatinine were determined and connected to histological conventional findings. Urinary d-lactate was analyzed using column-switching high-performance liquid chromatography with fluorescence detection. The results showed a remarkable increase of urinary markers, including of urinary proteins and N-acetyl-beta-d-glucosaminidase, and the histological examination confirmed a diagnosis of acute tubule necrosis. The ratio of d-lactate to creatinine in the urine of aristolochic acid-treated mice was approximately 36 times greater than that of the mice in the control group (p < 0.05). The ratios for the two groups of mice were 311.00 +/- 71.70 and 8.60 +/- 1.80 micromol/mmol creatinine, respectively. These data confirm in vivo that urinary d-lactate reflects renal injury conditions in aristolochic acid-treated mice and may be a marker for the assessment of nephropathy.

Aristoxazole analogues. Conversion of 8-nitro-1-naphthoic acid to 2-methylnaphtho[1,2-d]oxazole-9-carboxylic acid: comments on the chemical mechanism of formation of DNA adducts by the aristolochic acids.[Pubmed:22746540]

J Nat Prod. 2012 Jul 27;75(7):1414-8.

2-Methylnaphtho[1,2-d]oxazole-9-carboxylic acid was obtained by reduction of 8-nitro-1-naphthoic acid with zinc-acetic acid. This naphthoxazole is a condensation product between an 8-nitro-1-naphthoic acid reduction intermediate and acetic acid and is a lower homologue of aristoxazole, a similar condensation product of aristolochic acid I with acetic acid that was previously reported. Both oxazoles are believed to arise via a common nitrenium/carbocation ion mechanism that is likely related to that which leads to aristolochic acid-DNA-adducts.

Description

Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen.

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