BohemamineCAS# 72926-12-6 |
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| Cas No. | 72926-12-6 | SDF | Download SDF |
| PubChem ID | 175270 | Appearance | Oil |
| Formula | C14H18N2O3 | M.Wt | 262.30 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C2C(O2)C3(N1C(=CC3=O)NC(=O)C=C(C)C)C | ||
| Standard InChIKey | UARXZADXFDTXOF-OKVQYTGBSA-N | ||
| Standard InChI | InChI=1S/C14H18N2O3/c1-7(2)5-11(18)15-10-6-9(17)14(4)13-12(19-13)8(3)16(10)14/h5-6,8,12-13H,1-4H3,(H,15,18)/t8-,12+,13+,14+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The Actinosporangium sp.
| Description | 1. Bohemamine is a cell adhesion inhibitor, it inhibits adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 27.2 microg/ml . |
Bohemamine Dilution Calculator
Bohemamine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8124 mL | 19.0621 mL | 38.1243 mL | 76.2486 mL | 95.3107 mL |
| 5 mM | 0.7625 mL | 3.8124 mL | 7.6249 mL | 15.2497 mL | 19.0621 mL |
| 10 mM | 0.3812 mL | 1.9062 mL | 3.8124 mL | 7.6249 mL | 9.5311 mL |
| 50 mM | 0.0762 mL | 0.3812 mL | 0.7625 mL | 1.525 mL | 1.9062 mL |
| 100 mM | 0.0381 mL | 0.1906 mL | 0.3812 mL | 0.7625 mL | 0.9531 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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New cell-cell adhesion inhibitors from Streptomyces sp. UMA-044.[Pubmed:14563155]
J Antibiot (Tokyo). 2003 Aug;56(8):673-81.
Three compounds, NP25301 (1), NP25302 (2) and Bohemamine (3), inhibitors of cell adhesion based on LFA-1/ICAM-1, were isolated from the cultured broth of the strain Streptomyces sp. UMA-044. New compounds 1 and 2 were identified as 2-(3'-carbamoylphenoxy)acrylic acid methyl ester and deoxyBohemamine, respectively, based on spectroscopic analyses. Compounds 1 approximately 3 inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 29.5 microg/ml for 1, 24.3 microg/ml for 2, and 27.2 microg/ml for 3.
Draft Genome Sequence of Marine-Derived Streptomyces sp. TP-A0873, a Producer of a Pyrrolizidine Alkaloid Bohemamine.[Pubmed:25700394]
Genome Announc. 2015 Feb 19;3(1). pii: 3/1/e00008-15.
Streptomyces sp. TP-A0873, isolated from deep-sea water, produces three different classes of secondary metabolites: antimycin, Bohemamine, and alkylated butenolides. In order to assess the biosynthetic potential of this strain, draft genome sequencing was carried out. The genome contained at least 14 gene clusters for polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS).
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