C7280948Novel PRMT1 inhibitor CAS# 587850-67-7 |
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Quality Control & MSDS
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| Cas No. | 587850-67-7 | SDF | Download SDF |
| PubChem ID | 833539 | Appearance | Powder |
| Formula | C14H16N2O2S | M.Wt | 276.35 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | >13.9mg/mL in DMSO | ||
| Chemical Name | 4-amino-N-(2-phenylethyl)benzenesulfonamide | ||
| SMILES | C1=CC=C(C=C1)CCNS(=O)(=O)C2=CC=C(C=C2)N | ||
| Standard InChIKey | BYWZPUPRVIECEC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
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C7280948 is a novel PRMT1 inhibitor with IC50 value of 12.75 μM [1].
Protein arginine methyltransferase 1 (PRMT1) is a histone methyltransferase specific for histone H4. PRMT1 catalyzes the transfer of the methyl group from SAM to the guanidine nitrogen atoms of arginine residues to produce monomethyl arginines (MMA) and asymmetric dimethyl arginines (ADMA) [2].
C7280948 is a novel PRMT1 inhibitor. C7280948 interacts with aromatic residues at the hPRMT1 substrate binding pocket (Tyr 147 and Tyr 160) [1]. C7280948 inhibited hPRMT1 with IC50 value of 26.7 μM [3].
References:
[1]. Heinke R, Spannhoff A, Meier R, et al. Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. ChemMedChem, 2009, 4(1): 69-77.
[2]. Itoh Y, Suzuki T, Miyata N. Small-molecular modulators of cancer-associated epigenetic mechanisms. Mol Biosyst, 2013, 9(5): 873-896.
[3]. Bissinger EM, Heinke R, Spannhoff A, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem, 2011, 19(12): 3717-3731.
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