ChasmanineCAS# 5066-78-4 |
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Number of papers citing our products
| Cas No. | 5066-78-4 | SDF | Download SDF |
| PubChem ID | 165283 | Appearance | Powder |
| Formula | C25H41NO6 | M.Wt | 451.6 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CCN1CC2(CCC(C34C2C(C(C31)C5(CC(C6CC4C5C6O)OC)O)OC)OC)COC | ||
| Standard InChIKey | DBODJJZRZFZBBD-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C25H41NO6/c1-6-26-11-23(12-29-2)8-7-16(31-4)25-14-9-13-15(30-3)10-24(28,17(14)19(13)27)18(22(25)26)20(32-5)21(23)25/h13-22,27-28H,6-12H2,1-5H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Chasmanine, hypaconitine, and deoxyaconitine are anti-inflammatory pharmacodynamic components in Heishunpian (HSP) with positive relations with HSP efficacy. Chasmanine has insecticidal activities against larvae of Bradysia odoriphaga Yan et Zhang. |
| Targets | Immunology & Inflammation related |
| In vitro | Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum.[Pubmed: 21417277]J Agric Food Chem. 2011 Apr 27;59(8):3701-6.
Diterpenoid alkaloids from the Chinese traditional herbal [Pubmed: 22628040]Molecules. 2012 May 4;17(5):5187-94.
A practical and novel “standard addition” strategy to screen pharmacodynamic components in traditional Chinese medicine using Heishunpian as an example[Reference: WebLink]Rsc Advances, 2015, 5(28):22209-16.
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Chasmanine Dilution Calculator
Chasmanine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2143 mL | 11.0717 mL | 22.1435 mL | 44.287 mL | 55.3587 mL |
| 5 mM | 0.4429 mL | 2.2143 mL | 4.4287 mL | 8.8574 mL | 11.0717 mL |
| 10 mM | 0.2214 mL | 1.1072 mL | 2.2143 mL | 4.4287 mL | 5.5359 mL |
| 50 mM | 0.0443 mL | 0.2214 mL | 0.4429 mL | 0.8857 mL | 1.1072 mL |
| 100 mM | 0.0221 mL | 0.1107 mL | 0.2214 mL | 0.4429 mL | 0.5536 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum.[Pubmed:21417277]
J Agric Food Chem. 2011 Apr 27;59(8):3701-6.
The screening for insecticidal principles from several Chinese medicinal herbs showed that the ethanol extract of Aconitum episcopale roots possessed significant feeding deterrence against the red flour beetle, Tribolium castaneum . From the ethanol extract, six feeding deterrents were isolated by bioassay-guided fractionation. The compounds were identified as Chasmanine, crassicauline A, karacoline, sachaconitine, talatisamine, and yunaconitine from their spectroscopic data. Chasmanine, talatisamine, karacoline, and sachaconitine exhibited feeding deterrent activity against T. castaneum adults, with EC(50) values of 297.0, 342.8, 395.3, and 427.8 ppm, respectively. Yunaconitine and crassicauline A also possessed feeding deterrent activity against T. castaneum adults, with EC(50) values of 653.4 and 1134.5 ppm, respectively.
Diterpenoid alkaloids from the Chinese traditional herbal "Fuzi" and their cytotoxic activity.[Pubmed:22628040]
Molecules. 2012 May 4;17(5):5187-94.
Ten diterpenoid alkaloids, including eight aconitine-type C(1)(9)-diterpenoid alkaloids and two hetisine-type C(2)(0)-diterpenoid alkaloids, were isolated from the secondary roots of Aconitum carmichaeli Debx., known as "Fuzi" in Chinese traditional herbal medicine. Their structures were established on the basis of their spectroscopic data and comparison with those of the literature. Among these alkaloids, Chasmanine, oxonitine and 15-acetylsongoramine were isolated for the first time from this medicinal plant. The cytotoxic activity of the alkaloids were tested against several cell lines by the MTT method in which aconitine, hypaconitine, mesaconitne and oxonitine were found to strongly inhibit the growth of the HePG2 cell line, which showed that the existence and quantity of the ester groups have a significant influence on the cytotoxicity of the diterpenoid alkaloids.
