Clazamycin BCAS# 71774-49-7 |
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- Clazamycin A
Catalog No.:BCN1960
CAS No.:71806-55-8
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| Cas No. | 71774-49-7 | SDF | Download SDF |
| PubChem ID | 126335 | Appearance | Powder |
| Formula | C7H9ClN2O | M.Wt | 172.61 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,8S)-2-chloro-5-imino-2,3-dihydro-1H-pyrrolizin-8-ol | ||
| SMILES | C1C(CN2C1(C=CC2=N)O)Cl | ||
| Standard InChIKey | DVCHIDKMDZZKBR-CAHLUQPWSA-N | ||
| Standard InChI | InChI=1S/C7H9ClN2O/c8-5-3-7(11)2-1-6(9)10(7)4-5/h1-2,5,9,11H,3-4H2/t5-,7+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Clazamycin B is a novel pyrrolizidine antitumor antibiotic. |
| Targets | Antifection |
Clazamycin B Dilution Calculator
Clazamycin B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.7934 mL | 28.967 mL | 57.9341 mL | 115.8681 mL | 144.8352 mL |
| 5 mM | 1.1587 mL | 5.7934 mL | 11.5868 mL | 23.1736 mL | 28.967 mL |
| 10 mM | 0.5793 mL | 2.8967 mL | 5.7934 mL | 11.5868 mL | 14.4835 mL |
| 50 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.3174 mL | 2.8967 mL |
| 100 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.1587 mL | 1.4484 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Studies on the pyrrolizidine antitumor agent, clazamycin: interconversion of clazamycins A and B.[Pubmed:3668555]
J Nat Prod. 1987 May-Jun;50(3):360-7.
Clazamycin, a novel pyrrolizidine antitumor antibiotic, exists in aqueous solution as a mixture of two epimers, clazamycins A and B [1A, 1B], the ratio of which is pH dependent. Several lines of evidence are presented, including the results of trapping experiments and a study demonstrating base promoted interconversion of the two forms, that implicate an azacyclooctenone species [3] as an intermediate in the interconversion process. This result supports a previous observation, that the C6a carbinolamidine hydroxyl of clazamycin is unreactive towards nucleophiles and may be significant in helping to elucidate the mechanism of action of this antibiotic.
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