Cucurbitacin H

CAS# 751-95-1

Cucurbitacin H

Catalog No. BCN0917----Order now to get a substantial discount!

Product Name & Size Price Stock
Cucurbitacin H: 5mg Please Inquire In Stock
Cucurbitacin H: 10mg Please Inquire In Stock
Cucurbitacin H: 20mg Please Inquire Please Inquire
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Cucurbitacin H: 200mg Please Inquire Please Inquire
Cucurbitacin H: 500mg Please Inquire Please Inquire
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Quality Control of Cucurbitacin H

Number of papers citing our products

Chemical structure

Cucurbitacin H

3D structure

Chemical Properties of Cucurbitacin H

Cas No. 751-95-1 SDF Download SDF
PubChem ID 441818 Appearance Powder
Formula C30H46O8 M.Wt 534.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-17-[(2R)-2,5,6-trihydroxy-6-methyl-3-oxoheptan-2-yl]-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,11-dione
SMILES CC1(C2=CCC3C4(CC(C(C4(CC(=O)C3(C2CC(C1=O)O)C)C)C(C)(C(=O)CC(C(C)(C)O)O)O)O)C)C
Standard InChIKey ABNDMUIXCBUBLO-REQJDAJISA-N
Standard InChI InChI=1S/C30H46O8/c1-25(2)15-9-10-19-27(5)13-18(32)23(30(8,38)21(34)12-20(33)26(3,4)37)28(27,6)14-22(35)29(19,7)16(15)11-17(31)24(25)36/h9,16-20,23,31-33,37-38H,10-14H2,1-8H3/t16-,17+,18-,19+,20?,23+,27+,28-,29+,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Cucurbitacin H Dilution Calculator

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Cucurbitacin H Molarity Calculator

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Preparing Stock Solutions of Cucurbitacin H

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8702 mL 9.351 mL 18.7021 mL 37.4042 mL 46.7552 mL
5 mM 0.374 mL 1.8702 mL 3.7404 mL 7.4808 mL 9.351 mL
10 mM 0.187 mL 0.9351 mL 1.8702 mL 3.7404 mL 4.6755 mL
50 mM 0.0374 mL 0.187 mL 0.374 mL 0.7481 mL 0.9351 mL
100 mM 0.0187 mL 0.0935 mL 0.187 mL 0.374 mL 0.4676 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cucurbitacin H

Plausible mechanisms explaining the role of cucurbitacins as potential therapeutic drugs against coronavirus 2019.[Pubmed:33251326]

Inform Med Unlocked. 2020;21:100484.

In the year 2019, the potent zoonotic virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began to rage globally, which resulted in the World Health Organization (WHO) declaring it as a pandemic on March 11th, 2020. Although extensive research is currently ongoing worldwide to understand the molecular mechanism and disease pathogenicity of SARS-CoV-2, there are still many nuances to elucidate. Therefore, developing an appropriate vaccine or therapeutic drug to combat coronavirus 2019 (COVID-19) is exceedingly challenging. Such scenarios require multifaceted approaches to identify suitable contenders for drugs against COVID-19. In this context, investigating natural compounds found in food, spices, and beverages can lead to the discovery of lead molecules that could be repurposed to treat COVID-19. Sixteen cucurbitacin analogues were investigated for activity against the SARS-CoV-2 main protease protein (Mpro), angiotensin-converting enzyme 2 (ACE2) binding receptor, nonstructural protein 12 (NSP12) RNA-dependent RNA polymerase (RdRp), NSP13 helicase, and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway using several relevant tools and simulated screening methods. All key proteins were found to bind efficiently only with cucurbitacin G 2-glucoside and Cucurbitacin H with the lowest global energy. Further, the absorption, distribution, metabolism, and excretion (ADME) of all the cucurbitacins were analysed to explore their drug profiles. Cucurbitacin G 2-glucoside and H showed the best hits and all the analogues showed no adverse properties that would diminish their drug-likeness abilities. The encouraging results of the current study may lay the foundation for future research and development of effective measures and preventive medications against SARS-CoV-2.

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