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Cyclo(L-Pro-L-Ile)

CAS# 57089-60-8

Cyclo(L-Pro-L-Ile)

Catalog No. BCX0220----Order now to get a substantial discount!

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Cyclo(L-Pro-L-Ile): 5mg $725 In Stock
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Quality Control of Cyclo(L-Pro-L-Ile)

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Chemical structure

Cyclo(L-Pro-L-Ile)

3D structure

Chemical Properties of Cyclo(L-Pro-L-Ile)

Cas No. 57089-60-8 SDF Download SDF
PubChem ID 13654640 Appearance Oil
Formula C11H18N2O2 M.Wt 210.27
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S,8aS)-3-[(2S)-butan-2-yl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
SMILES CCC(C)C1C(=O)N2CCCC2C(=O)N1
Standard InChIKey ZDACRNZBFJOLTC-CIUDSAMLSA-N
Standard InChI InChI=1S/C11H18N2O2/c1-3-7(2)9-11(15)13-6-4-5-8(13)10(14)12-9/h7-9H,3-6H2,1-2H3,(H,12,14)/t7-,8-,9-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Cyclo(L-Pro-L-Ile) Dilution Calculator

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Cyclo(L-Pro-L-Ile) Molarity Calculator

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Preparing Stock Solutions of Cyclo(L-Pro-L-Ile)

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7558 mL 23.779 mL 47.5579 mL 95.1158 mL 118.8948 mL
5 mM 0.9512 mL 4.7558 mL 9.5116 mL 19.0232 mL 23.779 mL
10 mM 0.4756 mL 2.3779 mL 4.7558 mL 9.5116 mL 11.8895 mL
50 mM 0.0951 mL 0.4756 mL 0.9512 mL 1.9023 mL 2.3779 mL
100 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1889 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cyclo(L-Pro-L-Ile)

Bioactive 2(1H)-Pyrazinones and Diketopiperazine Alkaloids from a Tunicate-Derived Actinomycete Streptomyces sp.[Pubmed:27563872]

Molecules. 2016 Aug 24;21(9):1116.

As a part of our ongoing effort to allocate marine microbial bioactive leads, a tunicate-derived actinomycete, Streptomyces sp. Did-27, was investigated. Three new 2(1H)-pyrazinones derivatives, (S)-6-(sec-butyl)-3-isopropylpyrazin-2(1H)-one (1), (S)-3-(sec-butyl)-6-isopropylpyrazin-2(1H)-one (2) and (S)-6-(sec-butyl)-3-isobutylpyrazin-2(1H)-one (3), together with the known (1H)-pyrazinones analogues deoxymutaaspergillic acid (4), 3,6-diisobutyl-2(1H)-pyrazinone (5) and 3,6-di-sec-butyl-2(1H)-pyrazinone (6), and the diketopiperazine alkaloids cyclo(6-OH-d-Pro-l-Phe) (7), bacillusamide B (8), cyclo(l-Pro-l-Leu) and Cyclo(L-Pro-L-Ile) (10) were isolated from this strain. The structures of the compounds were determined by study of their one- and two-dimensional NMR spectra as well as high-resolution mass spectral determinations. Compound 4 was reported previously as a synthetic product, while compound 6 was reported as 2-hydroxy-3,6-di-sec-butylpyrazine. Herein, we report the complete NMR data for compounds 4 and 6. The compounds were evaluated for their cytotoxic activities against three cell lines. Compound 5 showed potent and selective activity against HCT-116 cell line with IC50 of 1.5 mug/mL, while 1-10 showed variable cytotoxic activities against these cancer cell lines. These results provide further understanding about the chemistry and bioactivities of the alkylated 2(1H)-pyrazinone derivatives.

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