D-Phe-OlCAS# 58917-85-4 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 58917-85-4 | SDF | Download SDF |
| PubChem ID | 736170 | Appearance | Powder |
| Formula | C17H19NO3 | M.Wt | 285.3 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | benzyl N-[(2R)-1-hydroxy-3-phenylpropan-2-yl]carbamate | ||
| SMILES | C1=CC=C(C=C1)CC(CO)NC(=O)OCC2=CC=CC=C2 | ||
| Standard InChIKey | WPOFMMJJCPZPAO-MRXNPFEDSA-N | ||
| Standard InChI | InChI=1S/C17H19NO3/c19-12-16(11-14-7-3-1-4-8-14)18-17(20)21-13-15-9-5-2-6-10-15/h1-10,16,19H,11-13H2,(H,18,20)/t16-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
D-Phe-Ol Dilution Calculator
D-Phe-Ol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5051 mL | 17.5254 mL | 35.0508 mL | 70.1016 mL | 87.6271 mL |
| 5 mM | 0.701 mL | 3.5051 mL | 7.0102 mL | 14.0203 mL | 17.5254 mL |
| 10 mM | 0.3505 mL | 1.7525 mL | 3.5051 mL | 7.0102 mL | 8.7627 mL |
| 50 mM | 0.0701 mL | 0.3505 mL | 0.701 mL | 1.402 mL | 1.7525 mL |
| 100 mM | 0.0351 mL | 0.1753 mL | 0.3505 mL | 0.701 mL | 0.8763 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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D-Phe-Ol
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A new series of highly potent growth hormone-releasing peptides derived from ipamorelin.[Pubmed:9733495]
J Med Chem. 1998 Sep 10;41(19):3699-704.
A new series of GH secretagogues derived from ipamorelin is described. In an attempt to obtain oral bioavailability, by reducing the size and the number of potential hydrogen-bonding sites of the compounds, a strategy using the peptidomimetic fragment 3-(aminomethyl)benzoic acid and sequential backbone N-methylations was applied. Several compounds from this series release GH with high in vitro potency and efficacy in a rat pituitary cell assay and high in vivo potency and efficacy in anesthetized rats. The tetrapeptide NNC 26-0235 (3-(aminomethyl)benzoyl-D-2Nal-N-Me-D-Phe-Lys-NH2) shows, following iv administration, comparable in vivo potency to ipamorelin, GHRP-2, and GHRP-6 with an ED50 in swine at 2 nmol/kg. NNC 26-0235 demonstrated a 10% oral bioavailability in dogs, and NNC 26-0235 and ipamorelin were able to increase basal GH level by more than 10-fold after oral administration of a dose of 1.8 and 2.7 mg/kg, respectively. The tripeptide NNC 26-0323 (3-(aminomethyl)benzoic acid-N-Me-D-2Nal-N-Me-D-Phe-Ol) which showed moderate in vitro potency but lacked in vivo potency demonstrated a 20% oral bioavailability in rats.
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