D-tetramannuronic acid tetrasodium saltCAS# 149511-34-2 |
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| Cas No. | 149511-34-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C24H34O25 | M.Wt | 722.51 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Marine alga
D-tetramannuronic acid tetrasodium salt Dilution Calculator
D-tetramannuronic acid tetrasodium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.3841 mL | 6.9203 mL | 13.8406 mL | 27.6813 mL | 34.6016 mL |
| 5 mM | 0.2768 mL | 1.3841 mL | 2.7681 mL | 5.5363 mL | 6.9203 mL |
| 10 mM | 0.1384 mL | 0.692 mL | 1.3841 mL | 2.7681 mL | 3.4602 mL |
| 50 mM | 0.0277 mL | 0.1384 mL | 0.2768 mL | 0.5536 mL | 0.692 mL |
| 100 mM | 0.0138 mL | 0.0692 mL | 0.1384 mL | 0.2768 mL | 0.346 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Protective effect of d-tetramannuronic acid tetrasodium salt on UVA-induced photo-aging in HaCaT cells.[Pubmed:32200257]
Biomed Pharmacother. 2020 Jun;126:110094.
UVA radiation from the sun is the main external stimulus in the pathogenesis of skin photo-aging. This process is associated with cellular oxidative stress. Here we aim at showing the protective effect of D-tetramannuronic acid tetrasodium salt (M4), a natural product, against UVA (30J/cm(2)) irradiation-induced oxidative stress and photo-aging in HaCaT cells, and to reveal the molecular mechanism underlying the protective efficacy. M4 pretreatment significantly increased HaCaT cell viability and MMP, suppressing UVA-induced ROS generation. Moreover, M4 treatment prevented the UVA-induced photo-aging of HaCaT cells (the reduction of cell viability, mitochondria dysfunction, and SIRT1/pGC-1alpha deregulation). Notably, the anti-photo-aging potential of M4 was directly associated with the increased expression of MMP and SIRT1, which was followed by the up-regulation of pGC-1alpha, D-LOOP, and Mt-TFA, and the transcriptional activation of NRF1/NRF2. Therefore, M4 is useful for the protection of skin cells from UVA-induced photo-aging.
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