L-hexaguluronic acid hexasodium saltCAS# 183668-74-8 |
- D-hexamannuronic acid hexasodium salt
Catalog No.:BCX1434
CAS No.:183668-52-2
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 183668-74-8 | SDF | Download SDF |
| PubChem ID | 156619317.0 | Appearance | Powder |
| Formula | C36H50O37 | M.Wt | 1074.76 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3S,4S,5S,6R)-6-[(2R,3S,4R,5S,6R)-2-carboxy-6-[(2R,3S,4R,5S,6R)-2-carboxy-6-[(2R,3S,4R,5S,6R)-2-carboxy-6-[(2R,3S,4R,5S,6R)-2-carboxy-6-[(2R,3S,4R,5S,6R)-2-carboxy-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid | ||
| SMILES | C1(C(C(OC(C1O)OC2C(C(C(OC2C(=O)O)OC3C(C(C(OC3C(=O)O)OC4C(C(C(OC4C(=O)O)OC5C(C(C(OC5C(=O)O)OC6C(C(C(OC6C(=O)O)O)O)O)O)O)O)O)O)O)O)O)C(=O)O)O)O | ||
| Standard InChIKey | SAJWPTZTWGBOFP-CAURGGIBSA-N | ||
| Standard InChI | InChI=1S/C36H50O37/c37-1-2(38)19(25(50)51)69-32(9(1)45)65-15-4(40)11(47)34(71-21(15)27(54)55)67-17-6(42)13(49)36(73-23(17)29(58)59)68-18-7(43)12(48)35(72-24(18)30(60)61)66-16-5(41)10(46)33(70-22(16)28(56)57)64-14-3(39)8(44)31(62)63-20(14)26(52)53/h1-24,31-49,62H,(H,50,51)(H,52,53)(H,54,55)(H,56,57)(H,58,59)(H,60,61)/t1-,2-,3+,4+,5+,6+,7+,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,31+,32+,33+,34+,35+,36+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
L-hexaguluronic acid hexasodium salt Dilution Calculator
L-hexaguluronic acid hexasodium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.9304 mL | 4.6522 mL | 9.3044 mL | 18.6088 mL | 23.261 mL |
| 5 mM | 0.1861 mL | 0.9304 mL | 1.8609 mL | 3.7218 mL | 4.6522 mL |
| 10 mM | 0.093 mL | 0.4652 mL | 0.9304 mL | 1.8609 mL | 2.3261 mL |
| 50 mM | 0.0186 mL | 0.093 mL | 0.1861 mL | 0.3722 mL | 0.4652 mL |
| 100 mM | 0.0093 mL | 0.0465 mL | 0.093 mL | 0.1861 mL | 0.2326 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- L-heptaguluronic acid heptasodium salt
Catalog No.:BCX1425
CAS No.:862694-87-9
- L-octaguluronic acid octasodium salt
Catalog No.:BCX1424
CAS No.:862694-88-0
- Chitoheptaose Heptahydrochloride
Catalog No.:BCX1423
CAS No.:127171-89-5
- Chitooctaose Octahydrochloride
Catalog No.:BCX1422
CAS No.:127171-90-8
- Chitotriose Trihydrochloride
Catalog No.:BCX1421
CAS No.:117436-78-9
- Chitobiose Octaacetate
Catalog No.:BCX1420
CAS No.:41670-99-9
- Chitotriose Undecaacetate
Catalog No.:BCX1419
CAS No.:53942-45-3
- Chitotetraose tetradecaacetate
Catalog No.:BCX1418
CAS No.:53942-46-4
- Chitopentaose Pentadecaacetate
Catalog No.:BCX1417
CAS No.:117399-52-7
- N,N'-Diacetylchitobiose
Catalog No.:BCX1416
CAS No.:35061-50-8
- N,N',N''-Triacetylchitotriose
Catalog No.:BCX1415
CAS No.:38864-21-0
- N,N',N'',N'''-Tetraacetylchitotetraose
Catalog No.:BCX1414
CAS No.:2706-65-2
- L-pentaguluronic acid pentasodium salt
Catalog No.:BCX1427
CAS No.:183668-72-6
- L-tetraguluronic acid tetrasodium salt
Catalog No.:BCX1428
CAS No.:149511-37-5
- L-triguluronic acid trisodium salt
Catalog No.:BCX1429
CAS No.:66754-14-1
- L-diguluronic acid disodium salt
Catalog No.:BCX1430
CAS No.:34044-54-7
- D-nonamannuronic acid nonasodium salt
Catalog No.:BCX1431
CAS No.:862694-99-3
- D-octamannuronic acid octasodium salt
Catalog No.:BCX1432
CAS No.:862694-98-2
- D-heptamannuronic acid heptasodium salt
Catalog No.:BCX1433
CAS No.:862694-97-1
- D-hexamannuronic acid hexasodium salt
Catalog No.:BCX1434
CAS No.:183668-52-2
- D-pentamannuronic acid pentasodium salt
Catalog No.:BCX1435
CAS No.:183668-50-0
- D-tetramannuronic acid tetrasodium salt
Catalog No.:BCX1436
CAS No.:149511-34-2
- D-trimannuronic acid trisodium salt
Catalog No.:BCX1437
CAS No.:66754-13-0
- D-dimannuronic acid disodium salt
Catalog No.:BCX1438
CAS No.:34044-53-6
Structural insights into the substrate-binding cleft of AlyF reveal the first long-chain alginate-binding mode.[Pubmed:33645537]
Acta Crystallogr D Struct Biol. 2021 Mar 1;77(Pt 3):336-346.
The products of alginate degradation, alginate oligosaccharides (AOS), have potential applications in many areas, including functional foods and marine drugs. Enzyme-based approaches using alginate lyases have advantages in the preparation of well defined AOS and have attracted much attention in recent years. However, a lack of structural insight into the whole substrate-binding cleft for most known alginate lyases severely hampers their application in the industrial generation of well defined AOS. To solve this issue, AlyF was co-crystallized with the long alginate oligosaccharide G6 (L-hexaguluronic acid hexasodium salt), which is the longest bound substrate in all solved alginate lyase complex structures. AlyF formed interactions with G6 from subsites -3 to +3 without additional substrate-binding site interactions, suggesting that the substrate-binding cleft of AlyF was fully occupied by six sugars, which was further confirmed by isothermal titration calorimetry and differential scanning calorimetry analyses. More importantly, a combination of structural comparisons and mutagenetic analyses determined that three key loops (loop 1, Lys215-Glu236; loop 2, Gln402-Ile416; loop 3, Arg334-Gly348) mainly function in binding long substrates (degree of polymerization of >4). The potential flexibility of loop 1 and loop 2 might enable the substrate to continue to enter the cleft after binding to subsites +1 to +3; loop 3 stabilizes and orients the substrate at subsites -2 and -3. Taken together, these results provide the first possible alginate lyase-substrate binding profile for long-chain alginates, facilitating the rational design of new enzymes for industrial purposes.
