DehydrodicentrineCAS# 19843-03-9 |
Quality Control & MSDS
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| Cas No. | 19843-03-9 | SDF | Download SDF |
| PubChem ID | 3084326 | Appearance | Powder |
| Formula | C20H19NO4 | M.Wt | 337.37 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 16,17-dimethoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.0^{2,6}.0^{8,20}.0^{14,19}]icosa-1(19),2(6),7,12(20),13,15,17-heptaene | ||
| SMILES | CN1CCC2=CC3=C(C4=C5C=C(C(=CC5=CC1=C24)OC)OC)OCO3 | ||
| Standard InChIKey | HIZKFQOZVOUKDP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H19NO4/c1-21-5-4-11-7-17-20(25-10-24-17)19-13-9-16(23-3)15(22-2)8-12(13)6-14(21)18(11)19/h6-9H,4-5,10H2,1-3H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM. |
| Targets | AChR |
| In vitro | Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.[Pubmed: 26028544]Fitoterapia. 2015 Jul;104:102-7.
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Dehydrodicentrine Dilution Calculator
Dehydrodicentrine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9641 mL | 14.8205 mL | 29.641 mL | 59.2821 mL | 74.1026 mL |
| 5 mM | 0.5928 mL | 2.9641 mL | 5.9282 mL | 11.8564 mL | 14.8205 mL |
| 10 mM | 0.2964 mL | 1.4821 mL | 2.9641 mL | 5.9282 mL | 7.4103 mL |
| 50 mM | 0.0593 mL | 0.2964 mL | 0.5928 mL | 1.1856 mL | 1.4821 mL |
| 100 mM | 0.0296 mL | 0.1482 mL | 0.2964 mL | 0.5928 mL | 0.741 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.[Pubmed:26028544]
Fitoterapia. 2015 Jul;104:102-7.
An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), Dehydrodicentrine (4), romerine (5), romeline (6), N-methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data. Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98muM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.
