Home >> Research Area >>Natural Products>>Alkaloids>> Dihydrolycorine

Dihydrolycorine

CAS# 6271-21-2

Dihydrolycorine

Catalog No. BCN2475----Order now to get a substantial discount!

Product Name & Size Price Stock
Dihydrolycorine: 5mg Please Inquire In Stock
Dihydrolycorine: 10mg Please Inquire In Stock
Dihydrolycorine: 20mg Please Inquire Please Inquire
Dihydrolycorine: 50mg Please Inquire Please Inquire
Dihydrolycorine: 100mg Please Inquire Please Inquire
Dihydrolycorine: 200mg Please Inquire Please Inquire
Dihydrolycorine: 500mg Please Inquire Please Inquire
Dihydrolycorine: 1000mg Please Inquire Please Inquire

Quality Control of Dihydrolycorine

Number of papers citing our products

Chemical structure

Dihydrolycorine

3D structure

Chemical Properties of Dihydrolycorine

Cas No. 6271-21-2 SDF Download SDF
PubChem ID 11876135 Appearance Cryst.
Formula C16H19NO4 M.Wt 289.33
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES C1CN2CC3=CC4=C(C=C3C5C2C1CC(C5O)O)OCO4
Standard InChIKey VJILFEGOWCJNIK-MGRBZGILSA-N
Standard InChI InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dihydrolycorine

The bulbus of Lycoris radiata (L. Herit.) Herb

Biological Activity of Dihydrolycorine

DescriptionDihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. It protects against anoxia damage of brain in rat.Dihydrolycorine-HCL shows hypotensive effects, it can block alpha 1-adrenoceptors.
TargetsAdrenergic Receptor
In vivo

Protective Effects of Dihydrolycorine on the Anoxia Brain Damage in Rat[Reference: WebLink]

Journal of Yunyang Medical College, 2002 , 21 (2) :71-72.

To investigate the effect of Dihydrolycorine on anoxia brain damage in rats.
METHODS AND RESULTS:
The model of hyperbicarbonatemia was used by stopping respirator to record the reemerge time and recovery percentage of EEG during reoxygenation for 10 minutes. Results The recovery percentage of control, DL(20 mg/kg), DL(40 mg/kg), nimodipine group is respectively (32.15±33.68)%, (75.40±17.12)%, (62.50±15.81)%, (80.00±12.26)%, which showed that the drug administered markedly improved recovery of the amplitude of EEG after reoxygenation compared with the controls.
CONCLUSIONS:
It suggests that DL and nimodipine protects against anoxia damage of brain in rat.

Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed: 944052]

Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.


METHODS AND RESULTS:
The effects of eighteen compounds obtained from bulbs of the Amaryllidaceae family were tested on (a) animal cell growth, (b) DNA, RNA and protein synthesis by intact cells and (c) protein synthesis in cell-free systems. Dihydrolycorine, haemanthamine, lycorine, narciclasine, pretazettine and pseudolycorine halted HeLa cell growth at 10(-1) mM or lower concentrations. These compounds at their growth inhibitory concentrations block protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Endomyocarditis virus RNA-directed cell-free polypeptide synthesis by an ascites S-30 extract and acetyl-[14C]leucyl-puromycin formation by ascites ribosomes are also inhibited by the six compounds indicated above.
CONCLUSIONS:
It is therefore concluded that they halt protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step.

Protocol of Dihydrolycorine

Animal Research

Hypotensive effect of dihydrolycorine.[Pubmed: 8503287]

Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.

Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb.
METHODS AND RESULTS:
DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively.
CONCLUSIONS:
These results suggest that DL can block alpha 1-adrenoceptors.

Dihydrolycorine Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Dihydrolycorine Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Dihydrolycorine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4563 mL 17.2813 mL 34.5626 mL 69.1252 mL 86.4065 mL
5 mM 0.6913 mL 3.4563 mL 6.9125 mL 13.825 mL 17.2813 mL
10 mM 0.3456 mL 1.7281 mL 3.4563 mL 6.9125 mL 8.6407 mL
50 mM 0.0691 mL 0.3456 mL 0.6913 mL 1.3825 mL 1.7281 mL
100 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.6913 mL 0.8641 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Dihydrolycorine

[Hypotensive effect of dihydrolycorine].[Pubmed:8503287]

Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.

Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively. These results suggest that DL can block alpha 1-adrenoceptors.

Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed:944052]

Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.

The effects of eighteen compounds obtained from bulbs of the Amaryllidaceae family were tested on (a) animal cell growth, (b) DNA, RNA and protein synthesis by intact cells and (c) protein synthesis in cell-free systems. Dihydrolycorine, haemanthamine, lycorine, narciclasine, pretazettine and pseudolycorine halted HeLa cell growth at 10(-1) mM or lower concentrations. These compounds at their growth inhibitory concentrations block protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Endomyocarditis virus RNA-directed cell-free polypeptide synthesis by an ascites S-30 extract and acetyl-[14C]leucyl-puromycin formation by ascites ribosomes are also inhibited by the six compounds indicated above. It is therefore concluded that they halt protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step.

Description

Dihydrolycorine is isolated from Lycoris radiate Herb with antihypertensive and neuroprotective activities. Dihydrolycorine is an inhibitor of protein synthesis in eukarytic cells by inhibiting the peptide bone formation step.

Keywords:

Dihydrolycorine,6271-21-2,Natural Products, buy Dihydrolycorine , Dihydrolycorine supplier , purchase Dihydrolycorine , Dihydrolycorine cost , Dihydrolycorine manufacturer , order Dihydrolycorine , high purity Dihydrolycorine

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: