DihydrolycorineCAS# 6271-21-2 |
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| Cas No. | 6271-21-2 | SDF | Download SDF |
| PubChem ID | 11876135 | Appearance | Cryst. |
| Formula | C16H19NO4 | M.Wt | 289.33 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | C1CN2CC3=CC4=C(C=C3C5C2C1CC(C5O)O)OCO4 | ||
| Standard InChIKey | VJILFEGOWCJNIK-MGRBZGILSA-N | ||
| Standard InChI | InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. It protects against anoxia damage of brain in rat.Dihydrolycorine-HCL shows hypotensive effects, it can block alpha 1-adrenoceptors. |
| Targets | Adrenergic Receptor |
| In vivo | Protective Effects of Dihydrolycorine on the Anoxia Brain Damage in Rat[Reference: WebLink]Journal of Yunyang Medical College, 2002 , 21 (2) :71-72.To investigate the effect of Dihydrolycorine on anoxia brain damage in rats. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed: 944052]Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.
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| Animal Research | Hypotensive effect of dihydrolycorine.[Pubmed: 8503287]Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. |
Dihydrolycorine Dilution Calculator
Dihydrolycorine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.4563 mL | 17.2813 mL | 34.5626 mL | 69.1252 mL | 86.4065 mL |
| 5 mM | 0.6913 mL | 3.4563 mL | 6.9125 mL | 13.825 mL | 17.2813 mL |
| 10 mM | 0.3456 mL | 1.7281 mL | 3.4563 mL | 6.9125 mL | 8.6407 mL |
| 50 mM | 0.0691 mL | 0.3456 mL | 0.6913 mL | 1.3825 mL | 1.7281 mL |
| 100 mM | 0.0346 mL | 0.1728 mL | 0.3456 mL | 0.6913 mL | 0.8641 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Hypotensive effect of dihydrolycorine].[Pubmed:8503287]
Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.
Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively. These results suggest that DL can block alpha 1-adrenoceptors.
Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed:944052]
Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.
The effects of eighteen compounds obtained from bulbs of the Amaryllidaceae family were tested on (a) animal cell growth, (b) DNA, RNA and protein synthesis by intact cells and (c) protein synthesis in cell-free systems. Dihydrolycorine, haemanthamine, lycorine, narciclasine, pretazettine and pseudolycorine halted HeLa cell growth at 10(-1) mM or lower concentrations. These compounds at their growth inhibitory concentrations block protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Endomyocarditis virus RNA-directed cell-free polypeptide synthesis by an ascites S-30 extract and acetyl-[14C]leucyl-puromycin formation by ascites ribosomes are also inhibited by the six compounds indicated above. It is therefore concluded that they halt protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step.
