DihydrolycorineCAS# 6271-21-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 6271-21-2 | SDF | Download SDF |
PubChem ID | 11876135 | Appearance | Cryst. |
Formula | C16H19NO4 | M.Wt | 289.33 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
SMILES | C1CN2CC3=CC4=C(C=C3C5C2C1CC(C5O)O)OCO4 | ||
Standard InChIKey | VJILFEGOWCJNIK-MGRBZGILSA-N | ||
Standard InChI | InChI=1S/C16H19NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h4-5,8,11,14-16,18-19H,1-3,6-7H2/t8-,11+,14+,15-,16-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step. It protects against anoxia damage of brain in rat.Dihydrolycorine-HCL shows hypotensive effects, it can block alpha 1-adrenoceptors. |
Targets | Adrenergic Receptor |
In vivo | Protective Effects of Dihydrolycorine on the Anoxia Brain Damage in Rat[Reference: WebLink]Journal of Yunyang Medical College, 2002 , 21 (2) :71-72.To investigate the effect of Dihydrolycorine on anoxia brain damage in rats. Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed: 944052]Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.
|
Animal Research | Hypotensive effect of dihydrolycorine.[Pubmed: 8503287]Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. |
Dihydrolycorine Dilution Calculator
Dihydrolycorine Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.4563 mL | 17.2813 mL | 34.5626 mL | 69.1252 mL | 86.4065 mL |
5 mM | 0.6913 mL | 3.4563 mL | 6.9125 mL | 13.825 mL | 17.2813 mL |
10 mM | 0.3456 mL | 1.7281 mL | 3.4563 mL | 6.9125 mL | 8.6407 mL |
50 mM | 0.0691 mL | 0.3456 mL | 0.6913 mL | 1.3825 mL | 1.7281 mL |
100 mM | 0.0346 mL | 0.1728 mL | 0.3456 mL | 0.6913 mL | 0.8641 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- NF 449
Catalog No.:BCC7043
CAS No.:627034-85-9
- Dioctanoylglycol
Catalog No.:BCC6662
CAS No.:627-86-1
- H-D-Arg-OH.HCl
Catalog No.:BCC2869
CAS No.:627-75-8
- Saikosaponin F
Catalog No.:BCN2776
CAS No.:62687-63-2
- Handelin
Catalog No.:BCN2953
CAS No.:62687-22-3
- 1-Hydroxy-2-methylanthraquinone
Catalog No.:BCN3478
CAS No.:6268-09-3
- SIB 1893
Catalog No.:BCC6970
CAS No.:6266-99-5
- Ro 106-9920
Catalog No.:BCC7175
CAS No.:62645-28-7
- 11S,12-Dihydroxyspirovetiv-1(10)-en-2-one
Catalog No.:BCN1391
CAS No.:62623-86-3
- (+)-Mellein
Catalog No.:BCN7220
CAS No.:62623-84-1
- 4,6,7-Trimethoxy-5-methylcoumarin
Catalog No.:BCN4166
CAS No.:62615-63-8
- 2',4'-Dihydroxy-3'-methoxyacetophenone
Catalog No.:BCN7535
CAS No.:62615-26-3
- SKF38393 HCl
Catalog No.:BCC6526
CAS No.:62717-42-4
- 4-Amino-N-methylbenzamide
Catalog No.:BCC8685
CAS No.:6274-22-2
- BMS-564929
Catalog No.:BCC1425
CAS No.:627530-84-1
- SD-208
Catalog No.:BCC1938
CAS No.:627536-09-8
- Epitrametol
Catalog No.:BCN7073
CAS No.:627538-65-2
- Pterophorine
Catalog No.:BCN2118
CAS No.:62786-99-6
- Senampeline A
Catalog No.:BCN2030
CAS No.:62787-00-2
- Senampeline D
Catalog No.:BCN2033
CAS No.:62787-01-3
- SU14813
Catalog No.:BCC1971
CAS No.:627908-92-3
- Palmitic acid ethyl ester
Catalog No.:BCN8298
CAS No.:628-97-7
- Jolkinol A
Catalog No.:BCN3778
CAS No.:62820-11-5
- Meglumine
Catalog No.:BCC4795
CAS No.:6284-40-8
[Hypotensive effect of dihydrolycorine].[Pubmed:8503287]
Zhongguo Yao Li Xue Bao. 1993 Jan;14(1):45-9.
Dihydrolycorine-HCL(DL) is a derivative of lycorine, an alkaloid isolated from Lycoris radiata Herb. DL iv 20, 40, and 80 mg.kg-1 lowered the mean arterial pressure in pentobar-bitone-anesthetized normotensive rats, cats, and conscious rats either normotensive or renovascular hypertensive. In pithed rats DL depressed the hypertensive effect of reaction to electric stimulation to the T7-9 segments of spinal cord. DL also depressed the hypertensive effect of phenylephrine. In rabbit aorta ring and rat anococcygeus muscle, DL antagonized the contractile effect of methoxamine, with pA2 values of 5.93 and 6.35, respectively. These results suggest that DL can block alpha 1-adrenoceptors.
Inhibitors of protein synthesis in eukarytic cells. Comparative effects of some amaryllidaceae alkaloids.[Pubmed:944052]
Biochim Biophys Acta. 1976 Mar 17;425(3):342-8.
The effects of eighteen compounds obtained from bulbs of the Amaryllidaceae family were tested on (a) animal cell growth, (b) DNA, RNA and protein synthesis by intact cells and (c) protein synthesis in cell-free systems. Dihydrolycorine, haemanthamine, lycorine, narciclasine, pretazettine and pseudolycorine halted HeLa cell growth at 10(-1) mM or lower concentrations. These compounds at their growth inhibitory concentrations block protein synthesis in ascites cells and stabilize HeLa cell polysomes in vivo. Endomyocarditis virus RNA-directed cell-free polypeptide synthesis by an ascites S-30 extract and acetyl-[14C]leucyl-puromycin formation by ascites ribosomes are also inhibited by the six compounds indicated above. It is therefore concluded that they halt protein synthesis in eukaryotic cells by inhibiting the peptide bone formation step.