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Epicorynoxidine

CAS# 58000-48-9

Epicorynoxidine

Catalog No. BCN7554----Order now to get a substantial discount!

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Chemical structure

Epicorynoxidine

3D structure

Chemical Properties of Epicorynoxidine

Cas No. 58000-48-9 SDF Download SDF
PubChem ID 21589011 Appearance Oil
Formula C21H25NO5 M.Wt 371.43
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (7R,13aS)-2,3,9,10-tetramethoxy-7-oxido-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium
SMILES COC1=C(C2=C(CC3C4=CC(=C(C=C4CC[N+]3(C2)[O-])OC)OC)C=C1)OC
Standard InChIKey QYEMUDHNCZHUKC-HTAPYJJXSA-N
Standard InChI InChI=1S/C21H25NO5/c1-24-18-6-5-13-9-17-15-11-20(26-3)19(25-2)10-14(15)7-8-22(17,23)12-16(13)21(18)27-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-,22+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Epicorynoxidine

The herbs of Corydalis tashiroi.

Biological Activity of Epicorynoxidine

DescriptionEpicorynoxidine is a natural product from Corydalis tashiroi.

Protocol of Epicorynoxidine

Structure Identification
Planta Med. 1999 Oct;65(7):643-7.

New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi.[Pubmed: 17260290 ]


METHODS AND RESULTS:
Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropalmatine, (-)-corydalmine, (-)-scoulerine, (-)-corynoxidine, (-)-Epicorynoxidine, palmatine, and protopine, have been isolated from the herb Corydalis tashiroi. The structures of these compounds were elucidated by spectroscopic analysis.
CONCLUSIONS:
Three of the isolated compounds show significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.

Epicorynoxidine Dilution Calculator

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Epicorynoxidine Molarity Calculator

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Preparing Stock Solutions of Epicorynoxidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6923 mL 13.4615 mL 26.923 mL 53.8459 mL 67.3074 mL
5 mM 0.5385 mL 2.6923 mL 5.3846 mL 10.7692 mL 13.4615 mL
10 mM 0.2692 mL 1.3461 mL 2.6923 mL 5.3846 mL 6.7307 mL
50 mM 0.0538 mL 0.2692 mL 0.5385 mL 1.0769 mL 1.3461 mL
100 mM 0.0269 mL 0.1346 mL 0.2692 mL 0.5385 mL 0.6731 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Epicorynoxidine

New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi.[Pubmed:17260290]

Planta Med. 1999 Oct;65(7):643-7.

Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropalmatine, (-)-corydalmine, (-)-scoulerine, (-)-corynoxidine, (-)-Epicorynoxidine, palmatine, and protopine, have been isolated from the herb Corydalis tashiroi. The structures of these compounds were elucidated by spectroscopic analysis. Three of the isolated compounds show significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.

Description

Epicorynoxidine is a natural alkaloid isolated from the herb Corydalis tashiroi. Epicorynoxidine shows cytotoxic effects P-388 cell line with an ED50 of 25.53 μg/mL.

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