Epimedoside A

CAS# 39012-04-9

Epimedoside A

2D Structure

Catalog No. BCN2886----Order now to get a substantial discount!

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Epimedoside A: 5mg $127 In Stock
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Quality Control of Epimedoside A

3D structure

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Epimedoside A

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Chemical Properties of Epimedoside A

Cas No. 39012-04-9 SDF Download SDF
PubChem ID 5317093 Appearance Yellow powder
Formula C32H38O15 M.Wt 662.7
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
SMILES CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)O)O)O)O
Standard InChIKey OGYXOOJUJQIDOX-FVCAYHPDSA-N
Standard InChI InChI=1S/C32H38O15/c1-12(2)4-9-16-18(44-32-27(42)25(40)22(37)19(11-33)45-32)10-17(35)20-23(38)30(47-31-26(41)24(39)21(36)13(3)43-31)28(46-29(16)20)14-5-7-15(34)8-6-14/h4-8,10,13,19,21-22,24-27,31-37,39-42H,9,11H2,1-3H3/t13-,19+,21-,22+,24+,25-,26+,27+,31-,32+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Epimedoside A

The herbs of Epimedium brevicornum Maxim

Biological Activity of Epimedoside A

DescriptionEpimedoside A has significant antioxidant activity in vitro.
In vitro

Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities.[Pubmed: 17613817]

Nat Prod Res. 2007 Jun;21(7):600-5.


METHODS AND RESULTS:
Seven flavonoids named diphylloside A, Epimedoside A, epimedin C, icariin, epimedoside C, icarisoside A, desmethylanhydroicaritin, as well as the oleanolic acid, were isolated from the roots of Epimedium wushanense for the first time. These flavonoids manifested significant antioxidant activity in vitro. Scavenging effects of two flavonoids were comparable to that of Vitamin C.
CONCLUSIONS:
Antibacterial experiment has shown that the diphylloside A, icarisoside A and desmethylanhydroicaritin have significant activity towards Pseudomonas aeruginosa.

Protocol of Epimedoside A

Structure Identification
Planta Med. 2000 Aug;66(6):575-7.

Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.[Pubmed: 10985091]

The MeOH extract of Epimedium sagittatum was found to show neurite outgrowth activity on cultured PC12h cells.
METHODS AND RESULTS:
Bioassay-guided fractionation of the MeOH extract yielded six prenylated flavonol glycosides, ikarisoside A (1), icarisid II (2), Epimedoside A (3), icariin (4), epimedin B (5), and epimedokoreanoside-I (6) as the active ingredients.

Epimedoside A Dilution Calculator

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Epimedoside A Molarity Calculator

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Preparing Stock Solutions of Epimedoside A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.509 mL 7.5449 mL 15.0898 mL 30.1796 mL 37.7245 mL
5 mM 0.3018 mL 1.509 mL 3.018 mL 6.0359 mL 7.5449 mL
10 mM 0.1509 mL 0.7545 mL 1.509 mL 3.018 mL 3.7724 mL
50 mM 0.0302 mL 0.1509 mL 0.3018 mL 0.6036 mL 0.7545 mL
100 mM 0.0151 mL 0.0754 mL 0.1509 mL 0.3018 mL 0.3772 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Epimedoside A

Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.[Pubmed:10985091]

Planta Med. 2000 Aug;66(6):575-7.

The MeOH extract of Epimedium sagittatum was found to show neurite outgrowth activity on cultured PC12h cells. Bioassay-guided fractionation of the MeOH extract yielded six prenylated flavonol glycosides, ikarisoside A (1), icarisid II (2), Epimedoside A (3), icariin (4), epimedin B (5), and epimedokoreanoside-I (6) as the active ingredients.

Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities.[Pubmed:17613817]

Nat Prod Res. 2007 Jun;21(7):600-5.

Seven flavonoids named diphylloside A, Epimedoside A, epimedin C, icariin, epimedoside C, icarisoside A, desmethylanhydroicaritin, as well as the oleanolic acid, were isolated from the roots of Epimedium wushanense for the first time. These flavonoids manifested significant antioxidant activity in vitro. Scavenging effects of two flavonoids were comparable to that of Vitamin C. Antibacterial experiment has shown that the diphylloside A, icarisoside A and desmethylanhydroicaritin have significant activity towards Pseudomonas aeruginosa.

Description

Epimedoside A is a flavonoid isolated from the roots of Epimedium wushanense. Epimedoside A exhibits significant antioxidant activity in vitro.

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