Buxbodine BCAS# 390362-51-3 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 390362-51-3 | SDF | Download SDF |
| PubChem ID | 91895280 | Appearance | Cryst. |
| Formula | C26H41NO2 | M.Wt | 399.6 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1S,3S,8R,11S,12S,14S,15S,16R)-15-[(1S)-1-(dimethylamino)ethyl]-14-hydroxy-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadec-4-en-6-one | ||
| SMILES | CC(C1C(CC2(C1(CCC34C2CCC5C3(C4)C=CC(=O)C5(C)C)C)C)O)N(C)C | ||
| Standard InChIKey | NZZQZWQHKWTQRO-YKKKOGGMSA-N | ||
| Standard InChI | InChI=1S/C26H41NO2/c1-16(27(6)7)21-17(28)14-24(5)19-9-8-18-22(2,3)20(29)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h10-11,16-19,21,28H,8-9,12-15H2,1-7H3/t16-,17-,18-,19-,21-,23+,24-,25+,26-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Buxus bodinieri Levl.
| Description | 1. Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM. |
| Targets | AChR |
Buxbodine B Dilution Calculator
Buxbodine B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5025 mL | 12.5125 mL | 25.025 mL | 50.0501 mL | 62.5626 mL |
| 5 mM | 0.5005 mL | 2.5025 mL | 5.005 mL | 10.01 mL | 12.5125 mL |
| 10 mM | 0.2503 mL | 1.2513 mL | 2.5025 mL | 5.005 mL | 6.2563 mL |
| 50 mM | 0.0501 mL | 0.2503 mL | 0.5005 mL | 1.001 mL | 1.2513 mL |
| 100 mM | 0.025 mL | 0.1251 mL | 0.2503 mL | 0.5005 mL | 0.6256 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bioactive steroidal alkaloids from Buxus macowanii Oliv.[Pubmed:25528196]
Steroids. 2015 Mar;95:73-9.
Chemical investigation of the crude methanolic extract of Buxus macowanii resulted in the isolation of five new steroidal alkaloids, 31-hydroxybuxatrienone (1), macowanioxazine (2), 16alpha-hydroxymacowanitriene (3), macowanitriene (4), macowamine (5), along with five known steroidal bases, Nb-demethylpapillotrienine (6), moenjodaramine (7), irehine (8), Buxbodine B (9) and buxmicrophylline C (10). Structures of compounds 1-10 were elucidated with the aid of spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. Compounds 1, 3, and 4 belong to a rare class of Buxus alkaloids having Delta(1,2) 9(10-->19) abeo triene system. All isolates were evaluated for in vitro acetylcholinesterase (AChE) inhibitory activity and found to exhibit moderate to weak anti-AChE activity with IC50 values in the range of 10.8-98muM. Compounds 1 and 6 were also moderately active in BACE1 inhibitory assay.
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