Esculentoside C

CAS# 65931-92-2

Esculentoside C

Catalog No. BCN5012----Order now to get a substantial discount!

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Quality Control of Esculentoside C

Number of papers citing our products

Chemical structure

Esculentoside C

3D structure

Chemical Properties of Esculentoside C

Cas No. 65931-92-2 SDF Download SDF
PubChem ID 10724099 Appearance White powder
Formula C42H66O15 M.Wt 810.97
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,4aR,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-10-[(2S,3R,4R,5R)-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-9-(hydroxymethyl)-2-methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
SMILES CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)OC6C(C(C(CO6)OC7C(C(C(C(O7)CO)O)O)O)O)O)C)C)C2C1)C)C(=O)O)C(=O)OC
Standard InChIKey NMDFCFOQBAHNPV-RFTJXAPBSA-N
Standard InChI InChI=1S/C42H66O15/c1-37(36(52)53-6)13-15-42(35(50)51)16-14-40(4)21(22(42)17-37)7-8-26-38(2)11-10-27(39(3,20-44)25(38)9-12-41(26,40)5)57-33-31(48)29(46)24(19-54-33)56-34-32(49)30(47)28(45)23(18-43)55-34/h7,22-34,43-49H,8-20H2,1-6H3,(H,50,51)/t22-,23+,24+,25+,26+,27-,28+,29-,30-,31+,32+,33-,34-,37-,38-,39-,40+,41+,42-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Esculentoside C

The roots of Phytolacca acinosa Roxb

Biological Activity of Esculentoside C

Description1. Esculentoside C exerts proinflammatory effects synergistically, it can induce inflammatory stimulation.
TargetsTNF-α | IL Receptor | NO

Esculentoside C Dilution Calculator

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Esculentoside C Molarity Calculator

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Preparing Stock Solutions of Esculentoside C

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2331 mL 6.1655 mL 12.3309 mL 24.6618 mL 30.8273 mL
5 mM 0.2466 mL 1.2331 mL 2.4662 mL 4.9324 mL 6.1655 mL
10 mM 0.1233 mL 0.6165 mL 1.2331 mL 2.4662 mL 3.0827 mL
50 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.4932 mL 0.6165 mL
100 mM 0.0123 mL 0.0617 mL 0.1233 mL 0.2466 mL 0.3083 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Esculentoside C

Rabbit conjunctivae edema and release of NO, TNF-alpha, and IL-1beta from macrophages induced by fractions and esculentosides isolated from Phytolacca americana.[Pubmed:25894210]

Pharm Biol. 2016;54(1):98-104.

CONTEXT: The roots of Phytolacca americana L. (Phytolaccaceae) may be toxic. Despite heated controversy over the toxic compounds of P. americana, especially esculentosides, relevant studies remain scarce. OBJECTIVE: The objective of this study is to screen the toxic fractions and compounds of P. americana, to determine the controlling indices, and to provide evidence for unraveling the mechanism. MATERIALS AND METHODS: Petroleum ether (PE), CH2Cl2, n-BuOH, and water fractions were isolated from 70% ethanol extract of P. americana. The n-BuOH fraction was dissolved in 50% ethanol and precipitated by adding ethyl ether. The resultant supernatants and precipitates were referred to as SUPs and SEDs fractions, respectively. SUPs fraction was separated by column chromatography into four main stimulating esculentosides that were identified by HR-ESI/MS and NMR as EsA, EsB, EsC, and EsF. The irritating effects of esculentosides on rabbit conjunctivae (500 mug/eye) was observed by pathological examination and those on macrophages (5, 25, 50 and 100 mug/mL) were evaluated by detecting changes of NO, TNF-alpha, and IL-1beta levels. RESULTS AND DISCUSSION: n-BuOH, SUP fractions, and EsC induced severe conjunctival edema. The four esculentosides induced dose-dependent releases of proinflammatory mediators NO, TNF-alpha, and IL-1beta from macrophages, and releasing amounts peaked after 2 h of treatment. EsC and EsF induced macrophages to release mediators most significantly. EsC (50 mug/mL) functioned more effectively than EsF did, and similarly n-BuOH and SUPs fractions functioned more effectively than the esculentoside mixture. Thus, the four esculentosides exerted proinflammatory effects synergistically. CONCLUSION: All extracted esculentosides, especially EsC, induced inflammatory stimulation. Phytolacca americana-induced irritation of the gastrointestinal tract may be associated with esculentosides such as EsC.

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