D-Glucosamine hydrochlorideCAS# 66-84-2 |
Quality Control & MSDS
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| Cas No. | 66-84-2 | SDF | Download SDF |
| PubChem ID | 2723635 | Appearance | Powder |
| Formula | C6H14ClNO5 | M.Wt | 215.63 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Synonyms | D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride | ||
| Solubility | H2O : ≥ 34 mg/mL (157.68 mM) DMSO : 6.2 mg/mL (28.75 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol;hydrochloride | ||
| SMILES | C(C1C(C(C(C(O1)O)N)O)O)O.Cl | ||
| Standard InChIKey | QKPLRMLTKYXDST-NSEZLWDYSA-N | ||
| Standard InChI | InChI=1S/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4-,5-,6?;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | D-glucosamine hydrochloride has antimicrobial effect on the common 21 strains of food spoilage microorganisms, it could as preservative agent was used to preserve nature eleo juice. D-glucosamine hydrochloride also has antitumor, antiinflammaty, and anti-arthritis effects, it induces cell apoptosis by blocking of cell-cycle. |
| Targets | TGF-β/Smad | TNF-α | COX | NOS | IL Receptor | Calcium Channel |
| In vitro | Effects of D-glucosamine hydrochloride on the cell-cycle and expression of proteins in gastric carcinoma cell SGC-7901[Reference: WebLink]Chinese Journal of Marine Drugs, 2008, 27(6):20-5.To study the effects of D-Glucosamine hydrochloride on the apoptosis of gastric carcinoma cell line SGC-7901 and its mechanism. Studies on Antimicrobial Effects of D-glucosamine Hydrochloride.[Reference: WebLink]Fisheries Science, 2001, 18(2):14-5.The antimicrobial effect of D-Glucosamine hydrochloride(GAH)was investigated. |
| In vivo | Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.[Pubmed: 23015778 ]Mar Drugs. 2012 Aug;10(8):1873-82.
Effect of fucoxanthin alone and in combination with D-glucosamine hydrochloride on carrageenan/kaolin-induced experimental arthritis in rats.[Pubmed: 24338843]Phytother Res. 2014 Jul;28(7):1054-63The objective of the present study was to investigate the effect of the fucoxanthin (FUCO) alone and in combination with glucosamine hydrochloride (GAH) on carrageenan/kaolin-induced inflammatory arthritis model in rats and to explore its underlying mechanisms. |
| Animal Research | Antitumor Effect of D-Glucosamine Hydrochloride in Mice[Reference: WebLink]Chinese Journal of Natural Medicines, 2003, 1(4):237-9.To study the antit umor effect of D-Glucosamine·HCl(D-GlcN·HCl) in tumor-bearing mice by ig route. |
D-Glucosamine hydrochloride Dilution Calculator
D-Glucosamine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.6376 mL | 23.1879 mL | 46.3757 mL | 92.7515 mL | 115.9393 mL |
| 5 mM | 0.9275 mL | 4.6376 mL | 9.2751 mL | 18.5503 mL | 23.1879 mL |
| 10 mM | 0.4638 mL | 2.3188 mL | 4.6376 mL | 9.2751 mL | 11.5939 mL |
| 50 mM | 0.0928 mL | 0.4638 mL | 0.9275 mL | 1.855 mL | 2.3188 mL |
| 100 mM | 0.0464 mL | 0.2319 mL | 0.4638 mL | 0.9275 mL | 1.1594 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Glucosamine (hydrochloride) is a natural product. IC50 value: Target: In vitro: Glucosamine hydrochloride exhibited dose-dependent DPPH antioxidant activity [1]. Short-term (4 h) glucosamine hydrochloride treatment inhibited HIF-1α at the protein level, decreased phosphorylation of p70S6K and S6, translation-related proteins [2]. In the obstructed kidneys and TGF-β1-treated renal cells, glucosamine hydrochloride significantly decreased renal expression of α-smooth muscle actin, collagen I, and fibronectin [3]. In vivo:
References:
[1]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.
[2]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.
[3]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.
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Effect of fucoxanthin alone and in combination with D-glucosamine hydrochloride on carrageenan/kaolin-induced experimental arthritis in rats.[Pubmed:24338843]
Phytother Res. 2014 Jul;28(7):1054-63.
The objective of the present study was to investigate the effect of the fucoxanthin (FUCO) alone and in combination with glucosamine hydrochloride (GAH) on carrageenan/kaolin-induced inflammatory arthritis model in rats and to explore its underlying mechanisms. Joint swelling, muscle weight ratio (%), histopathological examination and scoring, and proteoglycan degradation were examined. Pro-inflammatory interleukin (IL-1beta) and tumor necrosis (TNF-alpha) levels, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase(iNOS) protein expression and nitric oxide (NO) level in knee synovial tissue extract were analyzed using enzyme-linked immunosorbent assay, western blotting analysis, and Griess reagent assay, respectively. FUCO and FUCO + GAH not only may significantly reduce degrees of knee joint swelling and prevent against muscle atrophy, but also may significantly attenuate inflammation in synovial tissue, cartilage erosion, and proteoglycan loss. The efficacies of FUCO + GAH were stronger than that of GAH or FUCO. FUCO alone and FUCO + GAH can significantly inhibit upregulation of COX-2 and iNOS protein expressions, decrease of IL-1beta and TNF-alpha levels, and reduce NO production in knee synovial tissue extract. These results indicated that FUCO is an effective anti-arthritis agent through an antiinflammation mechanism. FUCO may enhance therapeutic effect of GAH on rat arthritis through mechanism of antiinflammation.
Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.[Pubmed:23015778]
Mar Drugs. 2012 Aug;10(8):1873-82.
D-Glucosamine hydrochloride (GlcNHCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcNHCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration. These results suggest that oral administration of GlcNHCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-beta).
