Punicalin

CAS# 65995-64-4

Punicalin

2D Structure

Catalog No. BCN4961----Order now to get a substantial discount!

Product Name & Size Price Stock
Punicalin: 5mg $242 In Stock
Punicalin: 10mg Please Inquire In Stock
Punicalin: 20mg Please Inquire Please Inquire
Punicalin: 50mg Please Inquire Please Inquire
Punicalin: 100mg Please Inquire Please Inquire
Punicalin: 200mg Please Inquire Please Inquire
Punicalin: 500mg Please Inquire Please Inquire
Punicalin: 1000mg Please Inquire Please Inquire

Quality Control of Punicalin

3D structure

Package In Stock

Punicalin

Number of papers citing our products

Chemical Properties of Punicalin

Cas No. 65995-64-4 SDF Download SDF
PubChem ID 5464368 Appearance Yellow crystalline
Formula C34H22O22 M.Wt 782.52
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in methanol and water
SMILES C1C2C(C(C(C(O2)O)O)O)OC(=O)C3=CC(=C(C(=C3C4=C(C(=C5C6=C4C(=O)OC7=C(C(=C(C8=C(C(=C(C=C8C(=O)O1)O)O)O)C(=C67)C(=O)O5)O)O)O)O)O)O)O
Standard InChIKey IQHIEHIKNWLKFB-ITTSEVFZSA-N
Standard InChI InChI=1S/C34H22O22/c35-6-1-4-9(19(39)17(6)37)11-15-13-14-16(33(50)56-28(13)23(43)21(11)41)12(22(42)24(44)29(14)55-32(15)49)10-5(2-7(36)18(38)20(10)40)31(48)54-27-8(3-52-30(4)47)53-34(51)26(46)25(27)45/h1-2,8,25-27,34-46,51H,3H2/t8-,25-,26-,27-,34-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Punicalin

1 Terminalia sp.

Biological Activity of Punicalin

DescriptionPunicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM).
TargetsHIV | Immunology & Inflammation related
In vivo

Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.[Pubmed: 10592846]

Am J Chin Med. 1999;27(3-4):371-6.

Punicalagin and Punicalin were isolated from the leaves of Terminalia catappa L.
METHODS AND RESULTS:
In this study, we evaluated the anti-inflammatory activity of punicalagin and Punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug treatment. After 4 hr of carrageenan administration, the best effect group was the punicalagin (10 mg/kg) treated group (inhibition rate was 58.15%), and the second was the punicalagin (5 mg/kg)-treated group (inhibition rate was 39.15%). However, even if the anti-inflammatory activity of punicalagin was the same as Punicalin at the 5 mg/kg dose, the inhibition effect from larger doses of punicalagin was increased, but there was a decrease with a larger dose of Punicalin.
CONCLUSIONS:
The data showed that both punicalagin and Punicalin exert anti-inflammatory activity, but treatment with larger doses of Punicalin may induce some cell damages.

Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats.[Pubmed: 9720629]

J Pharm Pharmacol. 1998 Jul;50(7):789-94.

Punicalagin and Punicalin, isolated from the leaves of Terminalia catappa L., are used to treat dermatitis and hepatitis. Both compounds have strong antioxidative activity. The antihepatotoxic activity of punicalagin and Punicalin on carbon tetrachloride (CCl4)-induced toxicity in the rat liver was evaluated.
METHODS AND RESULTS:
Levels of serum glutamate-oxalate-transaminase and glutamate-pyruvate-trans-aminase were increased by administration of CCl4 and reduced by drug treatment. Histological changes around the liver central vein and oxidation damage induced by CCl4 also benefited from drug treatment. The results show that both punicalagin and Punicalin have anti-hepatotoxic activity but that the larger dose of Punicalin induced liver damage.
CONCLUSIONS:
Thus even if tannins have strong antioxidant activity at very small doses, treatment with a larger dose will induce cell damage.

Protocol of Punicalin

Kinase Assay

Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV-1 reverse transcriptase.[Pubmed: 15472920]

Phytother Res. 2004 Aug;18(8):667-9.

The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded Punicalin and 2-O-galloylPunicalin, isolated for the first time from this species.
METHODS AND RESULTS:
These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner. Punicalin showed an IC(50) of 0.11 microg/ml (0.14 microM) and 2-O-galloylPunicalin an IC(50) of 0.10 microg/ml (0.11 microM).

Punicalin Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Punicalin Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Punicalin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2779 mL 6.3896 mL 12.7792 mL 25.5585 mL 31.9481 mL
5 mM 0.2556 mL 1.2779 mL 2.5558 mL 5.1117 mL 6.3896 mL
10 mM 0.1278 mL 0.639 mL 1.2779 mL 2.5558 mL 3.1948 mL
50 mM 0.0256 mL 0.1278 mL 0.2556 mL 0.5112 mL 0.639 mL
100 mM 0.0128 mL 0.0639 mL 0.1278 mL 0.2556 mL 0.3195 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Punicalin

Two ellagitannins from the leaves of Terminalia triflora with inhibitory activity on HIV-1 reverse transcriptase.[Pubmed:15472920]

Phytother Res. 2004 Aug;18(8):667-9.

The bioassay- guided fractionation of the aqueous extract of Terminalia triflora leaves afforded Punicalin and 2-O-galloylPunicalin, isolated for the first time from this species. These compounds showed inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner. Punicalin showed an IC(50) of 0.11 microg/ml (0.14 microM) and 2-O-galloylPunicalin an IC(50) of 0.10 microg/ml (0.11 microM).

Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.[Pubmed:10592846]

Am J Chin Med. 1999;27(3-4):371-6.

Punicalagin and Punicalin were isolated from the leaves of Terminalia catappa L. In this study, we evaluated the anti-inflammatory activity of punicalagin and Punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug treatment. After 4 hr of carrageenan administration, the best effect group was the punicalagin (10 mg/kg) treated group (inhibition rate was 58.15%), and the second was the punicalagin (5 mg/kg)-treated group (inhibition rate was 39.15%). However, even if the anti-inflammatory activity of punicalagin was the same as Punicalin at the 5 mg/kg dose, the inhibition effect from larger doses of punicalagin was increased, but there was a decrease with a larger dose of Punicalin. The data showed that both punicalagin and Punicalin exert anti-inflammatory activity, but treatment with larger doses of Punicalin may induce some cell damages.

Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats.[Pubmed:9720629]

J Pharm Pharmacol. 1998 Jul;50(7):789-94.

Punicalagin and Punicalin, isolated from the leaves of Terminalia catappa L., are used to treat dermatitis and hepatitis. Both compounds have strong antioxidative activity. The antihepatotoxic activity of punicalagin and Punicalin on carbon tetrachloride (CCl4)-induced toxicity in the rat liver was evaluated. Levels of serum glutamate-oxalate-transaminase and glutamate-pyruvate-trans-aminase were increased by administration of CCl4 and reduced by drug treatment. Histological changes around the liver central vein and oxidation damage induced by CCl4 also benefited from drug treatment. The results show that both punicalagin and Punicalin have anti-hepatotoxic activity but that the larger dose of Punicalin induced liver damage. Thus even if tannins have strong antioxidant activity at very small doses, treatment with a larger dose will induce cell damage.

Description

Punicalin is a hydrolyzable tannin isolated from Punica granatum L. or the leaves of Terminalia catappa L.. Punicalin is a anti-hepatitis B virus (HBV) agent and has anti-inflammatory activity.

Keywords:

Punicalin,65995-64-4,Natural Products, buy Punicalin , Punicalin supplier , purchase Punicalin , Punicalin cost , Punicalin manufacturer , order Punicalin , high purity Punicalin

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: