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Strophantidin

CAS# 66-28-4

Strophantidin

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Quality Control of Strophantidin

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Chemical structure

Strophantidin

3D structure

Chemical Properties of Strophantidin

Cas No. 66-28-4 SDF Download SDF
PubChem ID 6185 Appearance White-beige powder
Formula C23H32O6 M.Wt 404.5
Type of Compound Isoprenoids Storage Desiccate at -20°C
Synonyms Apocymarin; Convallatoxigenin; Corchorin; Corchoside A aglycone; Corchsularin; Erysimupicrone; k-Strophanthidine
Solubility Soluble in methan
Chemical Name (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
SMILES CC12CCC3C(C1(CCC2C4=CC(=O)OC4)O)CCC5(C3(CCC(C5)O)C=O)O
Standard InChIKey ODJLBQGVINUMMR-HZXDTFASSA-N
Standard InChI InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Strophantidin

1 Antiaris sp. 2 Castilla sp. 3 Convallaria sp. 4 Corchorus sp. 5 Erysimum sp.

Strophantidin Dilution Calculator

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Strophantidin Molarity Calculator

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Preparing Stock Solutions of Strophantidin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4722 mL 12.3609 mL 24.7219 mL 49.4438 mL 61.8047 mL
5 mM 0.4944 mL 2.4722 mL 4.9444 mL 9.8888 mL 12.3609 mL
10 mM 0.2472 mL 1.2361 mL 2.4722 mL 4.9444 mL 6.1805 mL
50 mM 0.0494 mL 0.2472 mL 0.4944 mL 0.9889 mL 1.2361 mL
100 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.4944 mL 0.618 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Strophantidin

Characterization of ouabain-induced phosphoinositide hydrolysis in brain slices of the neonatal rat.[Pubmed:1963925]

Neurochem Res. 1990 Oct;15(10):1023-9.

The effect of the Na/K-ATPase inhibitor ouabain on phosphoinositide (Ptdlns) hydrolysis was studied in rat brain cortical slices. Ouabain induced a dose-dependent accumulation of inositol phosphates (InsPs) which was much higher in neonatal rats (1570 +/- 40% of basal) than in adult animals (287 +/- 18% of basal). For this reason, all experiments were conducted with 7 day-old rats. Strophantidin caused a similar stimulation of Ptdlns hydrolysis, although it was less potent than ouabain. The order of potency for ouabain-stimulated InsPs accumulation in brain areas was hippocampus greater than cortex greater than brainstem greater than cerebellum. The effect of ouabain was not blocked by antagonists for the muscarinic, alpha1 -adrenergic and glutamate receptors. Also ineffective were the K+ channel blockers 4-aminopyridine and tetraethylammonium, the sodium channel blocker tetrodotoxin, and the calcium channel blocker verapamil, whereas the Na/Ca exchanger blocker amiloride partially antagonized the effect of ouabain. The accumulation of InsPs induced by ouabain was additive to that of carbachol and norepinephrine, as well as to that induced by high K+ and veratrine, but not to that of glutamate. Removal of Na+ ions from the incubation buffer completely prevented the accumulation of InsPs induced by ouabain. The effect of ouabain was also dependent upon extracellular calcium and was under negative feedback control of protein kinase C. Despite the higher effect of ouabain on Ptdlns hydrolysis of immature rats, the density of [3H]ouabain binding sites, as well as the activity of Na/K-ATPase were higher in adult animals. Furthermore, a poor correlation was found between ouabain-stimulated Ptdlns hydrolysis and [3H]ouabain binding in brain regions.(ABSTRACT TRUNCATED AT 250 WORDS)

Keywords:

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