Esculentoside H

CAS# 66656-92-6

Esculentoside H

Catalog No. BCN2795----Order now to get a substantial discount!

Product Name & Size Price Stock
Esculentoside H: 5mg $35 In Stock
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Quality Control of Esculentoside H

Number of papers citing our products

Chemical structure

Esculentoside H

3D structure

Chemical Properties of Esculentoside H

Cas No. 66656-92-6 SDF Download SDF
PubChem ID 3035624 Appearance Powder
Formula C48H76O21 M.Wt 989.1
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-O-methyl 4a-O-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (2R,4aR,6aR,6aS,6bR,9R,10R,11S,12aR,14bR)-10-[(2S,3R,4R,5R)-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-11-hydroxy-9-(hydroxymethyl)-2,6a,6b,9,12a-pentamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2,4a-dicarboxylate
SMILES CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)CO)OC6C(C(C(CO6)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)C)C)C2C1)C)C(=O)OC8C(C(C(C(O8)CO)O)O)O)C(=O)OC
Standard InChIKey UQCUBQIHIKJPHI-IEGHAIBGSA-N
Standard InChI InChI=1S/C48H76O21/c1-43(41(61)63-6)11-13-48(42(62)69-40-36(60)33(57)30(54)25(18-50)66-40)14-12-46(4)21(22(48)15-43)7-8-28-44(2)16-23(52)37(45(3,20-51)27(44)9-10-47(28,46)5)68-38-34(58)31(55)26(19-64-38)67-39-35(59)32(56)29(53)24(17-49)65-39/h7,22-40,49-60H,8-20H2,1-6H3/t22-,23+,24-,25-,26-,27?,28-,29-,30-,31+,32+,33+,34-,35-,36-,37+,38+,39+,40+,43-,44+,45+,46-,47-,48+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Esculentoside H

The roots of Phytolacca acinosa Roxb

Biological Activity of Esculentoside H

DescriptionPhytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.
TargetsTNF-α
In vitro

Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages.[Pubmed: 8010057]

Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.


METHODS AND RESULTS:
Effect of Esculentoside H (EH) on release of tumor necrosis factor (TNF) from murine peritoneal macrophage (Mphi) in vitro was studied. The results showed that Esculentoside H (12.5-200 micrograms.ml-1) induced the thioglycolate-broth elicited peritoneal Mphi to release TNF into supernatants in a dose-dependent manner, and higher levels of TNF activity were detected in the supernatants from Esculentoside H-stimulated calcimycin-primed Mø culture. Esculentoside H-induced TNF release had a different type of kinetics compared with that of lipopolysaccharides (LPS). LPS-induced release of TNF increased rapidly until 6 h after LPS stimulation, then declined gradually, while Esculentoside H-induced TNF release increased gradually after Esculentoside H stimulation and reached its peak at approximately 24 h later.
CONCLUSIONS:
These results suggested that the anti-tumor mechanisms of Phytolaccaceae may be related to the capacity of Esculentoside H for TNF release.

Esculentoside H Dilution Calculator

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Esculentoside H Molarity Calculator

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Preparing Stock Solutions of Esculentoside H

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.011 mL 5.0551 mL 10.1102 mL 20.2204 mL 25.2755 mL
5 mM 0.2022 mL 1.011 mL 2.022 mL 4.0441 mL 5.0551 mL
10 mM 0.1011 mL 0.5055 mL 1.011 mL 2.022 mL 2.5276 mL
50 mM 0.0202 mL 0.1011 mL 0.2022 mL 0.4044 mL 0.5055 mL
100 mM 0.0101 mL 0.0506 mL 0.1011 mL 0.2022 mL 0.2528 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Esculentoside H

Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages.[Pubmed:8010057]

Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.

Effect of Esculentoside H (EH) on release of tumor necrosis factor (TNF) from murine peritoneal macrophage (Mphi) in vitro was studied. The results showed that EH (12.5-200 micrograms.ml-1) induced the thioglycolate-broth elicited peritoneal Mphi to release TNF into supernatants in a dose-dependent manner, and higher levels of TNF activity were detected in the supernatants from EH-stimulated calcimycin-primed Mo culture. EH-induced TNF release had a different type of kinetics compared with that of lipopolysaccharides (LPS). LPS-induced release of TNF increased rapidly until 6 h after LPS stimulation, then declined gradually, while EH-induced TNF release increased gradually after EH stimulation and reached its peak at approximately 24 h later. These results suggested that the anti-tumor mechanisms of Phytolaccaceae may be related to the capacity of EH for TNF release.

Description

Esculentoside H (EsH) is a water-soluble saponin isolated and purified from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the

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