Gericudranin ECAS# 172104-07-3 |
Quality Control & MSDS
3D structure
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| Cas No. | 172104-07-3 | SDF | Download SDF |
| PubChem ID | 44559902 | Appearance | Powder |
| Formula | C22H18O7 | M.Wt | 394.37 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-6-[(4-hydroxyphenyl)methyl]-2,3-dihydrochromen-4-one | ||
| SMILES | C1=CC(=CC=C1CC2=C(C=C3C(=C2O)C(=O)C(C(O3)C4=CC=C(C=C4)O)O)O)O | ||
| Standard InChIKey | SFDDCVYUBBUSMV-FCHUYYIVSA-N | ||
| Standard InChI | InChI=1S/C22H18O7/c23-13-5-1-11(2-6-13)9-15-16(25)10-17-18(19(15)26)20(27)21(28)22(29-17)12-3-7-14(24)8-4-12/h1-8,10,21-26,28H,9H2/t21-,22+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Cudrania tricuspidata
| Description | 1. Gericudranin E shows significant hepatoprotective effects with the EC50 value of 39.87+/-0.7 microM. |
| Targets | MAO |
Gericudranin E Dilution Calculator
Gericudranin E Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5357 mL | 12.6784 mL | 25.3569 mL | 50.7138 mL | 63.3922 mL |
| 5 mM | 0.5071 mL | 2.5357 mL | 5.0714 mL | 10.1428 mL | 12.6784 mL |
| 10 mM | 0.2536 mL | 1.2678 mL | 2.5357 mL | 5.0714 mL | 6.3392 mL |
| 50 mM | 0.0507 mL | 0.2536 mL | 0.5071 mL | 1.0143 mL | 1.2678 mL |
| 100 mM | 0.0254 mL | 0.1268 mL | 0.2536 mL | 0.5071 mL | 0.6339 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Hepatoprotective compounds of the roots of Cudrania tricuspidata on tacrine-induced cytotoxicity in Hep G2 cells.[Pubmed:16595932]
Biol Pharm Bull. 2006 Apr;29(4):838-40.
The bioassay-guided fractionation of the MeOH extract of the root barks of Cudrania tricuspidata furnished three hepatoprotective compounds, gerontoxanthone A (2), cudraflavone B (4), Gericudranin E (5), together with four prenylated xanthones, cudraxanthone B (3), isocudraxanthone K (6), cudraxanthone C (7), cudraxanthone H (8), and a prenylated flavanone, euchrestaflavanone C (1). Compounds 4 and 5 showed significant hepatoprotective effects with the EC50 values of 37.39+/-0.4 and 39.87+/-0.7 microM, respectively, and compound 2 showed moderate hepatoprotective effect with an EC50 value of 125.9+/-1.5 microM, against tacrine-induced cytotoxicity in Hep G2 cells. Silybin as positive control showed an EC50 value of 84.76+/-0.5 microM. Isocudraxanthone K (6) is a new compound.
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