Mepivacaine HClCAS# 1722-62-9 |
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Quality Control & MSDS
3D structure
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| Cas No. | 1722-62-9 | SDF | Download SDF |
| PubChem ID | 66070 | Appearance | Powder |
| Formula | C15H23ClN2O | M.Wt | 282.81 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | H2O : 100 mg/mL (353.59 mM; Need ultrasonic) | ||
| Chemical Name | N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide;hydrochloride | ||
| SMILES | [H+].[Cl-].CN1CCCCC1C(=O)Nc2c(C)cccc2C | ||
| Standard InChIKey | RETIMRUQNCDCQB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Mepivacaine HCl Dilution Calculator
Mepivacaine HCl Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5359 mL | 17.6797 mL | 35.3594 mL | 70.7189 mL | 88.3986 mL |
| 5 mM | 0.7072 mL | 3.5359 mL | 7.0719 mL | 14.1438 mL | 17.6797 mL |
| 10 mM | 0.3536 mL | 1.768 mL | 3.5359 mL | 7.0719 mL | 8.8399 mL |
| 50 mM | 0.0707 mL | 0.3536 mL | 0.7072 mL | 1.4144 mL | 1.768 mL |
| 100 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.7072 mL | 0.884 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mepivacaine is a tertiary amine used as a local anesthetic.
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[Combined ischiatic/3-in-1-block. II. 1 percent mepivacaine HCl versus 1 percent CO2 mepivacaine].[Pubmed:2841724]
Reg Anaesth. 1988 Apr;11(2):50-3.
In a prospective randomized study on 26 patients, the clinical effectiveness CO2-mepivacaine 1% (group 1, 13 patients) and Mepivacaine HCl 1% (group 2, 13 patients), was tested in patients having a sciatic-femoral block for surgical procedures of the lower extremity (20 ml for sciatic and 30 ml for 3-in-1 block). Blood levels of mepivacaine were determined for up to 90 min in 8 patients from each group. The onset of sensory and motor blockade was slightly earlier (4-5 min) with CO2-mepivacaine than with the hydrochloride (5-6 min). The time to complete block was 8-11 min with CO2-mepivacaine and 11-12 min with Mepivacaine HCl. There was a relatively large variance in intensity of blockade that was not necessarily related to the drug employed, but can be explained by individual factors and possibly by slight differences in blocking technique. Nevertheless, the rate of unsuccessful blockade was remarkably higher (38%) with the hydrochloride than with CO2-mepivacaine (7.7%). Determinations of blood levels did show the expected earlier peak (after 20-30 min) and higher blood-levels (means 3.8 micrograms/ml at 30 min) with CO2-mepivacaine 1% as compared to Mepivacaine HCl 1%: 2.9 micrograms/ml at 30 min and 3.4 micrograms/ml at 45 min.
Cardiovascular alterations caused by the administration of 2% mepivacaine HCl with 1:20,000 levonordefrin (Carbocain) in dogs.[Pubmed:9590931]
Braz Dent J. 1997;8(2):85-90.
We studied possible cardiovascular effects (systolic, diastolic, mean arterial blood pressures, and heart rate) caused by intraoral infiltrative administration of 2% Mepivacaine HCl with 1:20,000 levonordefrin in dogs (Canis familiaris), using a Beckman electrophysiograph. Doses used were 0.514 and 1.542 mg/kg body weight corresponding to one and three 1.8-ml cartridges, respectively, in 70-kg average weight adult men. A statistically significant increase was observed in the systolic and the mean arterial blood pressures.
Serum levels of mepivacaine-HCl during continuous axillary brachial plexus block.[Pubmed:2486591]
Reg Anesth. 1989 May-Jun;14(3):124-7.
In order to find out whether repeated doses of plain mepivacaine are appropriate for long-lasting microvascular surgery, a catheter-induced axillary plexus block was performed in 17 patients by using 400 mg of mepivacaine-HC1 every two hours. All patients underwent replantation surgery of one or more amputated fingers. Duration of operation varied from 8 to 24 hours. In all cases, there was adequate analgesia and muscle relaxation for the surgical procedure. Serum levels of mepivacaine were determined before, and 15 and 60 minute after the initial injection. With each following injection of mepivacaine, blood samples were taken at the same time schedule. Within the first eight hours, after four 400 mg doses of mepivacaine were given, all serum levels remained below the level of 5 to 6 micrograms/ml, which is said to be the lower level for mild cerebral toxic reactions in venous blood (blood/plasma distribution 0.92 +/- 0.04). After this time, when more than 1600 mg of mepivacaine had been administered, two patients exceeded the level of 6 micrograms/ml. The highest serum concentration observed in any of the patients was 7.0 micrograms/ml. This was 15 minutes after the 12th injection of 400 mg of mepivacaine and an overall dosage of 4800 mg. None of the patients showed evident signs of central nervous system or cardiovascular toxicity.
[Comparison of the effect and serum level of mepivacaine HCL and mepivacaine CO2 in axillary brachial plexus anesthesia].[Pubmed:3086948]
Reg Anaesth. 1986 Apr;9(2):42-5.
The latency period and spread of axillary plexus block using 40 ml mepivacaine carbonate (1% solution) or mepivacaine hydrochloride was studied in thirty patients scheduled for surgery of the hand-forearm region. The sensory block of the nervus axillaris, musculocutaneus, radialis, medianus, ulnaris and cutaneus brachii medialis was recorded using the pin prick test every 4 min after injection and the motor block was assessed by testing the strength of the corresponding muscles. The only significant difference between the two local anaesthetic solutions was a few more frequent and faster anaesthesia of the nervus musculocutaneus after 16, 20 and 24 min. A comparison between the serum levels of the first five patients of each group showed a faster increase and a higher level after the injection of carbonated mepivacaine. Carbonated mepivacaine doesn't have any practical advantage for axillary plexus block.
