2-(Hydroxymethyl)anthraquinoneCAS# 17241-59-7 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 17241-59-7 | SDF | Download SDF |
| PubChem ID | 87014 | Appearance | Yellow cryst. |
| Formula | C15H10O3 | M.Wt | 238.2 |
| Type of Compound | Anthraquinones | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2-(hydroxymethyl)anthracene-9,10-dione | ||
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C=C(C=C3)CO | ||
| Standard InChIKey | JYKHAJGLEVKEAA-UHFFFAOYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. 2-(Hydroxymethyl)anthraquinone exhibits strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. |
| Targets | Antifection |
2-(Hydroxymethyl)anthraquinone Dilution Calculator
2-(Hydroxymethyl)anthraquinone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.1982 mL | 20.9908 mL | 41.9815 mL | 83.9631 mL | 104.9538 mL |
| 5 mM | 0.8396 mL | 4.1982 mL | 8.3963 mL | 16.7926 mL | 20.9908 mL |
| 10 mM | 0.4198 mL | 2.0991 mL | 4.1982 mL | 8.3963 mL | 10.4954 mL |
| 50 mM | 0.084 mL | 0.4198 mL | 0.8396 mL | 1.6793 mL | 2.0991 mL |
| 100 mM | 0.042 mL | 0.2099 mL | 0.4198 mL | 0.8396 mL | 1.0495 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- 2-Hydroxy-3-methylanthraquinone
Catalog No.:BCN1108
CAS No.:17241-40-6
- Dihydrodaidzein
Catalog No.:BCN2819
CAS No.:17238-05-0
- 2-Hydroxy-3-methoxybenzoic acid glucose ester
Catalog No.:BCN7407
CAS No.:172377-87-6
- Scabioside C
Catalog No.:BCC8358
CAS No.:17233-22-6
- PKC β pseudosubstrate
Catalog No.:BCC5811
CAS No.:172308-76-8
- Mepivacaine HCl
Catalog No.:BCC4796
CAS No.:1722-62-9
- Ilaprazole
Catalog No.:BCC9000
CAS No.:172152-36-2
- Gericudranin E
Catalog No.:BCN8070
CAS No.:172104-07-3
- Alpha-Tocotrienol
Catalog No.:BCN3724
CAS No.:1721-51-3
- H-Phe(4-NO2)-OMe.HCl
Catalog No.:BCC3294
CAS No.:17193-40-7
- SCH 51344
Catalog No.:BCC5613
CAS No.:171927-40-5
- Palmatine chloride monohydrate
Catalog No.:BCC8228
CAS No.:171869-95-7
- Coumurrayin
Catalog No.:BCN1109
CAS No.:17245-25-9
- 3',4',5',3,5,6,7-Heptamethoxyflavone
Catalog No.:BCN1110
CAS No.:17245-30-6
- 9-Deacetyl-9-benzoyl-10-debenzoyltaxchinin A
Catalog No.:BCN7671
CAS No.:172486-22-5
- Eupatarone
Catalog No.:BCN7199
CAS No.:17249-61-5
- Senkyunolide R
Catalog No.:BCC9144
CAS No.:172549-37-0
- Naringin 4'-glucoside
Catalog No.:BCN8196
CAS No.:17257-21-5
- Murrayamine E
Catalog No.:BCN7908
CAS No.:172617-68-4
- Eucalyptone
Catalog No.:BCN1111
CAS No.:172617-99-1
- Clemastanin A
Catalog No.:BCC8151
CAS No.:172670-47-2
- Fosaprepitant
Catalog No.:BCC4281
CAS No.:172673-20-0
- Fmoc-β-Homo-Val-OH
Catalog No.:BCC2626
CAS No.:172695-33-9
- Senkyunolide S
Catalog No.:BCC9145
CAS No.:172723-28-3
Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori.[Pubmed:16359837]
J Ethnopharmacol. 2006 Apr 21;105(1-2):255-62.
The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) bioassays. The activity of the isolated compounds was compared to that of the commercially available anti-Helicobacter pylori agents, amoxicillin, metronidazole, and tetracycline. The biologically active components of Tabebuia impetiginosa dried inner bark (taheebo) were characterized by spectroscopic analysis as 2-(Hydroxymethyl)anthraquinone, anthraquinone-2-carboxylic acid, and 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). With the paper disc diffusion assay 2-(Hydroxymethyl)anthraquinone exhibited strong activity against Helicobacter pylori ATCC 43504 at 0.01 mg/disc. Anthraquinone-2-carboxylic acid, lapachol and metronidazole were less effective, exhibiting moderate anti-Helicobacter pylori activity at 0.1 mg/disc. Amoxicillin and tetracycline were the most potent compounds tested, displaying very strong activity at 0.005 mg/disc. 2-(Hydroxymethyl)anthraquinone exhibited moderate activity at this dose. Tetracycline still had strong activity at 0.001 mg/disc while amoxicillin had little activity at this dose. In the MIC bioassay, 2-(Hydroxymethyl)anthraquinone (2 microg/mL), anthraquinone-2-carboxylic acid (8 microg/mL), and lapachol (4 microg/mL) were more active than metronidazole (32 microg/mL) but less effective than amoxicillin (0.063 microg/mL) and tetracycline (0.5 microg/mL). The anti-Helicobacter pylori activity of seven 1,4-naphthoquinone derivatives (structurally related to lapachol), 1,4-naphthoquinone, 5,8-dihydroxy-1,4-naphthoquinone (naphthazarin), 2-methyl-1,4-naphthoquinone (menadione), 2-hydroxy-1,4-naphthoquinone (lawsone), 5-hydroxy-2-methyl-1,4-naphthoquinone (plumbagin), 5-hydroxy-1,4-naphthoquinone (juglone), and 2,3-dichloro-1,4-naphthoquinone (dichlone) was also evaluated using the paper disc assay. Menadione and plumbagin were the most potent compounds tested with the later still exhibiting very strong activity at 0.001 mg/disc. Menadione, juglone and tetracycline had strong activity at this low dose while the latter two compounds and amoxicillin had very strong activity at 0.005 mg/disc. Lawsone was unusual in that it had very strong activity at 0.1 and 0.05 mg/disc but weak activity at doses of 0.01 mg/disc and lower. Naphthazalin, lapachol and dichlone had similar activities while metronidazole had the lowest activity of all compounds tested. These results may be an indication of at least one of the pharmacological actions of taheebo. The Tabebuia impetiginosa dried inner bark-derived materials, particularly 2-(Hydroxymethyl)anthraquinone, merit further study as potential Helicobacter pylori eradicating agents or lead compounds.
