Glycoside St-JCAS# 203513-88-6 |
Quality Control & MSDS
Package In Stock
Number of papers citing our products
| Cas No. | 203513-88-6 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C54H86O23 | M.Wt | 1103.25 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | Scheffleraside II | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Glycoside St-J Dilution Calculator
Glycoside St-J Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.9064 mL | 4.5321 mL | 9.0641 mL | 18.1283 mL | 22.6603 mL |
| 5 mM | 0.1813 mL | 0.9064 mL | 1.8128 mL | 3.6257 mL | 4.5321 mL |
| 10 mM | 0.0906 mL | 0.4532 mL | 0.9064 mL | 1.8128 mL | 2.266 mL |
| 50 mM | 0.0181 mL | 0.0906 mL | 0.1813 mL | 0.3626 mL | 0.4532 mL |
| 100 mM | 0.0091 mL | 0.0453 mL | 0.0906 mL | 0.1813 mL | 0.2266 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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The Antitumor Effects of Triterpenoid Saponins from the Anemone flaccida and the Underlying Mechanism.[Pubmed:24191167]
Evid Based Complement Alternat Med. 2013;2013:517931.
Anemone flaccida Fr. Schmidt, a family of ancient hopanoids, have been used as traditional Asian herbs for the treatments of inflammation and convulsant diseases. Previous study on HeLa cells suggested that triterpenoid saponins from Anemone flaccida Fr. Schmidt may have potential antitumor effect due to their apoptotic activities. Here, we confirmed the apoptotic activities of the following five triterpenoid saponins: glycoside St-I4a (1), Glycoside St-J (2), anhuienoside E (3), hedera saponin B (4), and flaccidoside II (5) on human BEL-7402 and HepG2 hepatoma cell lines, as well as the model of HeLa cells treated with lipopolysaccharide (LPS). We found that COX-2/PGE2 signaling pathway, which plays key roles in the development of cancer, is involved in the antitumor activities of these saponins. These data provide the evidence that triterpenoid saponins can induce apoptosis via COX-2/PGE2 pathway, implying a preventive role of saponins from Anemone flaccida in tumor.
Triterpenoid saponins from Anemone flaccida induce apoptosis activity in HeLa cells.[Pubmed:19219723]
J Asian Nat Prod Res. 2009;11(2):122-7.
Five triterpenoid saponins were isolated from Anemone flaccida Fr. Schmidt. Their structures were identified as glycoside St-I4a (1), Glycoside St-J (2), anhuienoside E (3), hederasaponin B (4), and flaccidoside II (5). Compounds 1-2 were isolated from Anemone family for the first time, and compounds 3-4 were isolated from this plant for the first time. The inhibitory effects of saponins on proliferation of HeLa cells were studied by MTT assay, the apoptosis-induction activity was observed by cell-cycle analysis and caspase-3 expression assay. The antitumor activities of the saponins were ranked in the following order: 5 > 3 > 4 > 1 > 2. The data presented here indicated that naturally occurring triterpenoid saponins can be regarded as excellent structures for the potential development of new anticancer agents.
