Gymnemic acid ICAS# 122168-40-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 122168-40-5 | SDF | Download SDF |
PubChem ID | 11953919 | Appearance | Powder |
Formula | C43H66O14 | M.Wt | 806.97 |
Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8S,8aR,9R,10R,12aS,14aR,14bR)-8a-(acetyloxymethyl)-8,9-dihydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid | ||
SMILES | CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)O)O)O)C)COC(=O)C)O | ||
Standard InChIKey | VEFSVJGWJQPWFS-ZXKKMYOJSA-N | ||
Standard InChI | InChI=1S/C43H66O14/c1-10-21(2)36(53)57-34-33(50)43(20-54-22(3)45)24(17-38(34,4)5)23-11-12-26-39(6)15-14-28(55-37-31(49)29(47)30(48)32(56-37)35(51)52)40(7,19-44)25(39)13-16-41(26,8)42(23,9)18-27(43)46/h10-11,24-34,37,44,46-50H,12-20H2,1-9H3,(H,51,52)/b21-10+/t24-,25+,26+,27-,28-,29-,30-,31+,32-,33-,34-,37+,39-,40-,41+,42+,43-/m0/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Gymnemic acids have been reported to effect a natural treatment for diabetes. 2. Gymnemic acids inhibit rabbit glyceraldehyde-3-phosphate dehydrogenase and induce a smearing of its electrophoretic band and dephosphorylation. |
Gymnemic acid I Dilution Calculator
Gymnemic acid I Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.2392 mL | 6.196 mL | 12.392 mL | 24.7841 mL | 30.9801 mL |
5 mM | 0.2478 mL | 1.2392 mL | 2.4784 mL | 4.9568 mL | 6.196 mL |
10 mM | 0.1239 mL | 0.6196 mL | 1.2392 mL | 2.4784 mL | 3.098 mL |
50 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.4957 mL | 0.6196 mL |
100 mM | 0.0124 mL | 0.062 mL | 0.1239 mL | 0.2478 mL | 0.3098 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Skepinone-L
Catalog No.:BCC1953
CAS No.:1221485-83-1
- BP 554 maleate
Catalog No.:BCC6695
CAS No.:1221401-95-1
- Meliasenin B
Catalog No.:BCN6112
CAS No.:1221262-77-6
- ML 202
Catalog No.:BCC6306
CAS No.:1221186-52-2
- Dehydroborapetoside B
Catalog No.:BCN6601
CAS No.:1221178-16-0
- Acarbose sulfate
Catalog No.:BCC4284
CAS No.:1221158-13-9
- ER-878898
Catalog No.:BCC8958
CAS No.:122111-11-9
- Gemcitabine HCl
Catalog No.:BCC1076
CAS No.:122111-03-9
- 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate
Catalog No.:BCC8575
CAS No.:122111-01-7
- Auraptenol
Catalog No.:BCN6113
CAS No.:1221-43-8
- 3,4-Dihydro-3,4-dihydroxynaphthalen-1(2H)-one
Catalog No.:BCN1602
CAS No.:1220891-22-4
- Charantadiol A
Catalog No.:BCN3483
CAS No.:1220890-23-2
- NPS-1034
Catalog No.:BCC6504
CAS No.:1221713-92-3
- 5'-Geranyl-5,7,2',4'-tetrahydroxyflavone
Catalog No.:BCN1601
CAS No.:1221762-70-4
- Boc-Dap(Fmoc)-OH
Catalog No.:BCC2665
CAS No.:122235-70-5
- 3-Epimeliasenin B
Catalog No.:BCN4723
CAS No.:1222475-77-5
- ML133 HCl
Catalog No.:BCC5006
CAS No.:1222781-70-5
- ML324
Catalog No.:BCC5575
CAS No.:1222800-79-4
- Torin 1
Catalog No.:BCC3676
CAS No.:1222998-36-8
- Torin 2
Catalog No.:BCC4606
CAS No.:1223001-51-1
- QL-IX-55
Catalog No.:BCC1876
CAS No.:1223002-54-7
- Vermisporin
Catalog No.:BCN1863
CAS No.:122301-98-8
- 6''-O-acetylisovitexin
Catalog No.:BCN6114
CAS No.:1223097-20-8
- Rosiglitazone
Catalog No.:BCC2264
CAS No.:122320-73-4
Production of Gymnemic Acid from Cell Suspension Cultures of Gymnema sylvestre.[Pubmed:27108321]
Methods Mol Biol. 2016;1391:229-39.
Gymnema sylvestre R. Br. is a popular herbal medicine. It has been used in ayurvedic system of medicine for thousands of years. It is popularly called as "Gur-mar" for its distinctive property of temporarily destroying the taste of sweetness and is used in the treatment of diabetes. The leaves of gymnema possess antidiabetic, antimicrobial, anti-hypercholesterolemic, anti-sweetener, anti-inflammatory, and hepatoprotective properties and have traditional uses in the treatment of asthma, eye complaints, and snake bite. The leaves contain triterpene saponins such as gymnemic acid which is an active ingredient of Gymnema. Since the cultivation of G. sylvestre is a very slow process and the content of gymnemic acid depends on the environmental factors, cell suspension culture is sought as an alternative means for the production of Gymnema biomass and to enhance the gymnemic acid content. In this chapter, the methods employed for the induction of callus and subsequent establishment of cell suspension cultures for the production of biomass and analysis of gymnemic acid using high performance liquid chromatography are described.
Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.[Pubmed:28256837]
J Nat Prod. 2017 Apr 28;80(4):909-915.
The plant Gymnema sylvestre has been used widely in traditional medicine as a remedy for several diseases, and its leaf extract is known to contain a group of bioactive triterpene saponins belonging to the gymnemic acid class. Gymnemic acid I (1) is one of the main components among this group of secondary metabolites and is endowed with an interesting bioactivity profile. Since there is a lack of information about its specific biological targets, the full interactome of 1 was investigated through a quantitative chemical proteomic approach, based on stable-isotope dimethyl labeling. The ribosome complex was found to be the main partner of compound 1, and a full validation of the proteomics results was achieved by orthogonal approaches. Further biochemical and biological investigations revealed an inhibitory effect of 1 on the ribosome machinery.
Elicitation of gymnemic acid production in cell suspension cultures of Gymnema sylvestre R.Br. through endophytic fungi.[Pubmed:28330304]
3 Biotech. 2016 Dec;6(2):232.
The enhancement of plant secondary metabolite production in cell suspension cultures through biotic or abiotic elicitation has become a potential biotechnological approach for commercialization or large-scale production of bioactive compounds. Gymnema sylvestre R.Br. is an important medicinal plant, rich in a group of oleanane triterpenoid saponins called gymnemic acid, well known for its anti-diabetic activity. Two endophytic fungal strains were isolated from the leaves of G. sylvestre and identified as Polyancora globosa and Xylaria sp. based on the PCR amplification and internal transcribed spacer (ITS 1-5.8S-ITS 2) sequencing of 18S rRNA gene. The process of elicitation of cell suspension cultures of G. sylvestre with dried powder of fungal mycelia (DPFM) and extracellular culture filtrate (ECF) of endophytic fungi consistently enhanced the accumulation of gymnemic acid and the DPFM was proved to be an effective elicitor when compared to the ECF. The DPFM elicited the gymnemic acid content in the range of 2.57-10.45-fold, while the ECF elicited the gymnemic acid content in the range of 2.39-7.8-fold. P. globosa, a novel and a rare endophytic fungal strain, has shown a great influence on the production of gymnemic acid. Cell suspension cultures elicited with DPFM of P. globosa produced higher amount of gymnemic acid content (124.23 mg/g dried cell weight) compared to the cultures elicited with DPFM of Xylaria sp. (102.24 mg/g DCW). But the cultures treated with consortium of DPFM of both fungi showed great influence on the production of gymnemic acid (139.98 mg/g DCW) than the cultures treated with DPFM alone. Similarly, cultures treated with consortium of ECF of both fungi produced more gymnemic acid content (94.86 mg/g DCW) compared with cultures treated with ECF of Xylaria sp. (77.93 mg/g DCW) and ECF of P. globosa (78.65 mg/g DCW) alone.
Hairy Root Cultures of Gymnema sylvestre R. Br. to Produce Gymnemic Acid.[Pubmed:27108334]
Methods Mol Biol. 2016;1391:427-43.
Gymnema sylvestre R. Br. (Asclepiadaceae) is an endangered species extensively used in the management of diabetes, obesity, and treatment of various diseases. Uncontrolled exploitation to meet the increasing demand and low seed viability hastens the disappearance of the plant from its natural habitat. Hairy root culture provides a suitable alternative for the enhanced production of active principles. The current protocol provides the optimized culture conditions for the establishment of hairy root cultures and elicitation studies and also confirmation of stable integration of A. rhizogenes plasmid T-DNA into host genetic material by PCR and RT-PCR. Furthermore, it also discusses the suitable methods for the extraction procedures, and qualitative and quantitative analysis of gymnemic acid by HPTLC and HPLC.