H-Thr(tBu)-OHCAS# 4378-13-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 4378-13-6 | SDF | Download SDF |
PubChem ID | 6951357 | Appearance | Powder |
Formula | C8H17NO3 | M.Wt | 175.2 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | (2S,3R)-2-amino-3-[(2-methylpropan-2-yl)oxy]butanoic acid | ||
SMILES | CC(C(C(=O)O)N)OC(C)(C)C | ||
Standard InChIKey | NMJINEMBBQVPGY-RITPCOANSA-N | ||
Standard InChI | InChI=1S/C8H17NO3/c1-5(6(9)7(10)11)12-8(2,3)4/h5-6H,9H2,1-4H3,(H,10,11)/t5-,6+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
H-Thr(tBu)-OH Dilution Calculator
H-Thr(tBu)-OH Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 5.7078 mL | 28.5388 mL | 57.0776 mL | 114.1553 mL | 142.6941 mL |
5 mM | 1.1416 mL | 5.7078 mL | 11.4155 mL | 22.8311 mL | 28.5388 mL |
10 mM | 0.5708 mL | 2.8539 mL | 5.7078 mL | 11.4155 mL | 14.2694 mL |
50 mM | 0.1142 mL | 0.5708 mL | 1.1416 mL | 2.2831 mL | 2.8539 mL |
100 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.1416 mL | 1.4269 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
H-Thr(tBu)-OH
- Salinosporamide A (NPI-0052, Marizomib)
Catalog No.:BCC2094
CAS No.:437742-34-2
- Crategolic acid
Catalog No.:BCN5487
CAS No.:4373-41-5
- Xanthinol nicotinate
Catalog No.:BCC9191
CAS No.:437-74-1
- Genkwanin
Catalog No.:BCN5488
CAS No.:437-64-9
- Gentisin
Catalog No.:BCN7518
CAS No.:437-50-3
- MRS 2365
Catalog No.:BCC5879
CAS No.:436847-09-5
- Tetrodotoxin
Catalog No.:BCN1035
CAS No.:4368-28-9
- Kobe0065
Catalog No.:BCC5290
CAS No.:436133-68-5
- JKC 363
Catalog No.:BCC6022
CAS No.:436083-30-6
- Ajmaline
Catalog No.:BCN3867
CAS No.:4360-12-7
- Fangchinoline
Catalog No.:BCN5956
CAS No.:436-77-1
- Diffractic Acid
Catalog No.:BCN8506
CAS No.:436-32-8
- 4-(4-Aminophenyl)morpholin-3-one
Catalog No.:BCC8650
CAS No.:438056-69-0
- SMI-4a
Catalog No.:BCC2233
CAS No.:438190-29-5
- Quercetin 3,3'-dimethyl ether
Catalog No.:BCN7781
CAS No.:4382-17-6
- Dihydrorobinetin
Catalog No.:BCN5489
CAS No.:4382-33-6
- Robtin
Catalog No.:BCN5490
CAS No.:4382-34-7
- Perakine
Catalog No.:BCN5491
CAS No.:4382-56-3
- PFK-015
Catalog No.:BCC5280
CAS No.:4382-63-2
- 3(20)-Phytene-1,2-diol
Catalog No.:BCN6589
CAS No.:438536-34-6
- JIP-1 (153-163)
Catalog No.:BCC5777
CAS No.:438567-88-5
- 2-Amino-3-methylbenzoic acid
Catalog No.:BCC8528
CAS No.:4389-45-1
- Gentianine
Catalog No.:BCN5492
CAS No.:439-89-4
- O-2093
Catalog No.:BCC7070
CAS No.:439080-01-0
N alpha-trifluoroacetylation of N-terminal hydroxyamino acids: a new side reaction in peptide synthesis.[Pubmed:1450523]
Pept Res. 1992 Sep-Oct;5(5):287-92.
In the synthesis of the double-chain bis-cystinyl hinge fragment 225-232/225'-232' of the human IgG1, which contains two N-terminal threonine residues, the final acidolytic deprotection step, with 99% aqueous trifluoroacetic acid, was accompanied by formation of remarkable amounts of an unknown side product. This has been identified as the N alpha-mono-trifluoroacetylated product; however, even bis-trifluoroacetylation was found to occur by prolonged exposure of the parallel dimer to the reaction medium. Similarly, the model compounds H-Thr(tBu)-Phe-OH, [Boc-Thr(tBu)-Cys-OH]2 and Boc-Thr(tBu)-Cys(StBu)-Ala-OH were acylated by treatment with trifluoroacetic acid at rates that suggest a rather pronounced sequence dependency. Since, on the other hand, the model compound [Boc-Ala-Cys-OH]2 was not trifluoroacetylated at all under identical conditions, the reaction has to proceed prevalently via intermediate formation of the trifluoroacetyl ester of N-terminal hydroxyamino acids, followed by O-->N shift according to the hydroxyoxazolidine mechanism. The experimental data indicate also that under favored conditions aminolysis of the trifluoroacetyl ester via an inter- or intramolecular pathway may contribute to the overall reaction rate.
Sequence-assisted peptide synthesis (SAPS).[Pubmed:9924991]
J Pept Res. 1998 Dec;52(6):470-6.
In solid-phase peptide synthesis (SPPS) the growing peptide chain may undergo chain aggregation which can cause serious synthetic problems. A number of investigations concerning this problem have been reported in the chemical literature. During a study of such "difficult sequences" using the Fmoc-protection strategy, we have observed that peptide-chain aggregation may be significantly reduced when certain amino acid sequences are incorporated C-terminally (1). Thus, synthesis of the difficult poly-alanine, (Ala)n, sequence (n < or = 20) has been investigated with (Lys(Boc))m (m < or = 6) and (Glu(tBu))m (m > or = 6) as pre-sequences. With m > or = 3, peptides are obtained as single, homogeneous products while a complex mixture of deletion peptides and corresponding Fmoc-protected peptides is formed (n > or = 6) without the pre-sequence. A mixed pre-sequence, (Lys(Boc)Glu(tBu))3, has a similar favorable effect on the synthetic results, but the positive effect seems confined to a rather narrow framework of amino acids and side-chain protecting groups in the pre-sequence as discussed in the article. Among other reputedly difficult sequences the synthesis of H-(Thr-Val)5-OH, H-Val-Asn-Val-Asn-Val-Gln-Val-Gln-Val-Asp-OH, the Acyl Carrier Protein (65-74) and the human insulin B-chain has been investigated. In all cases introduction of a pre-sequence gives rise to satisfactory synthetic results. In the latter case, the lysine pre-sequence may be cleaved enzymatically to give the desB30 insulin B-chain. NIR-FT Raman studies of the synthesis of the poly-alanine, (Ala)n, sequences have shown that the pre-sequence (Lys(Boc))6 shifts the conformation of the growing peptide chain from a beta-structure (n > or = 6) to a random coil conformation (1c). This result is in agreement with the general observation that SPPS proceeds optimally under random coil conditions.