GentianineCAS# 439-89-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 439-89-4 | SDF | Download SDF |
| PubChem ID | 354616 | Appearance | Powder |
| Formula | C10H9NO2 | M.Wt | 175.2 |
| Type of Compound | Iridoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-ethenyl-3,4-dihydropyrano[3,4-c]pyridin-1-one | ||
| SMILES | C=CC1=C2CCOC(=O)C2=CN=C1 | ||
| Standard InChIKey | DFNZYFAJQPLJFI-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C10H9NO2/c1-2-7-5-11-6-9-8(7)3-4-13-10(9)12/h2,5-6H,1,3-4H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Gentianine has anti-diabetic effect. 2. Gentianine has antipsychotic activity. 3. Gentianine has potential anti-inflammatory action, might be at least partly based on the suppressed production of TNF-alpha and IL-6. 4. Gentianine has diuretic activity, it could be developed as a safe antihypertensive drug. 5. Gentianine has hypotensive effect, it can produce a decrease in heart rate and systolic, diastolic and mean arterial blood pressure. 6. Gentianine has a protective effect on hippocampal CA1 neurons in rats subjected to recurrent febrile convulsion (FC), it can ameliorate FC-induced neuronal injury by enhancing glutamate acid decarboxylase activity, decreasing glutamate levels and increasing γ-aminobutyric acid levels. |
| Targets | PPAR | GLUT | TNF-α | IL Receptor | Sodium Channel | Potassium Channel |
Gentianine Dilution Calculator
Gentianine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 5.7078 mL | 28.5388 mL | 57.0776 mL | 114.1553 mL | 142.6941 mL |
| 5 mM | 1.1416 mL | 5.7078 mL | 11.4155 mL | 22.8311 mL | 28.5388 mL |
| 10 mM | 0.5708 mL | 2.8539 mL | 5.7078 mL | 11.4155 mL | 14.2694 mL |
| 50 mM | 0.1142 mL | 0.5708 mL | 1.1416 mL | 2.2831 mL | 2.8539 mL |
| 100 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.1416 mL | 1.4269 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS).[Pubmed:15802824]
Biol Pharm Bull. 2005 Apr;28(4):750-3.
This study was undertaken to elucidate the mechanism of anti-inflammatory action of Gentianine, a constituent of Gentiana Macrophylla. The effects of Gentianine on lipopolysacharide (LPS)-induced production of pro-inflammatory cytokines were investigated in male Sprague-Dawley rats. For the first time, we found that oral administration of Gentianine (10-100 mg/kg) suppressed the increases in tumor necrosis factor-alpha (TNF-alpha) (ED(50), 37.7 mg/kg) and interleukin (IL)-6 (ED(50), 38.5 mg/kg) in the sera from the rats challenged with bacterial LPS (100 microg/kg; i.p.). However, LPS induced production of other interleukins, such as IL-alpha, was not significantly altered by Gentianine. These results suggest that the potential anti-inflammatory action of Gentianine might be at least partly based on the suppressed production of TNF-alpha and IL-6.
Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-gamma gene expression in 3T3-L1 cells.[Pubmed:22718571]
Phytother Res. 2013 Apr;27(4):624-7.
We have previously shown the anti-diabetic effects of swertiamarin; however, pharmacokinetic analysis showed that swertiamarin had a plasma half-life of 1.3 h. Gentianine is an active metabolite of swertiamarin that possesses a pharmacophoric moiety. The aim of this study was to explore the possibility whether the anti-diabetic effect of swertiamarin is due to Gentianine. Swertiamarin treatment had no significant effect on adipogenesis, or the mRNA expression of PPAR-gamma and GLUT-4; however, there was a significant increase in the mRNA expression of adiponectin. On the other hand, treatment with Gentianine significantly increased adipogenesis, which was associated with a significant increase in the mRNA expression of PPAR-gamma, GLUT-4 and adiponectin. These findings suggest, for the first time, that the anti-diabetic effect of swertiamarin is due to Gentianine, an active metabolite of swertiamarin.
