Isorhamnetin-3-O-galactosideCAS# 6743-92-6 |
- Isorhamnetin-3-O-beta-D-Glucoside
Catalog No.:BCN1247
CAS No.:5041-82-7
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 6743-92-6 | SDF | Download SDF |
| PubChem ID | 86328677 | Appearance | Powder |
| Formula | C22H22O12 | M.Wt | 478.4 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | ||
| SMILES | COC1=C(C=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O | ||
| Standard InChIKey | CQLRUIIRRZYHHS-HEQLHBKPSA-N | ||
| Standard InChI | InChI=1S/C22H22O12/c1-31-12-4-8(2-3-10(12)25)20-21(17(28)15-11(26)5-9(24)6-13(15)32-20)34-22-19(30)18(29)16(27)14(7-23)33-22/h2-6,14,16,18-19,22-27,29-30H,7H2,1H3/t14-,16-,18+,19+,22+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Isorhamnetin 3-O-galactoside shows antioxidant activity. 2. Isorhamnetin 3-O-galactoside has neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of severe vascular inflammatory diseases. 3. Isorhamnetin 3-O-galactoside has potential anticoagulant activity, it possesses antithrombotic and profibrinolytic activity and offers bases for development of a novel anticoagulant. 4. Isorhamnetin 3-O-galactoside has anti-inflammatory activity against HMGB1-induced inflammatory responses in both HUVECs and CLP-induced septic mice. 5. Isorhamnetin 3-O-galactoside is a 5-lipoxygenase inhibitor, it may have therapeutic potential in skin inflammatory disorders in traditional medicine. |
| Targets | NF-kB | TNF-α | ERK | JNK | p38MAPK | LOX |
Isorhamnetin-3-O-galactoside Dilution Calculator
Isorhamnetin-3-O-galactoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0903 mL | 10.4515 mL | 20.903 mL | 41.806 mL | 52.2575 mL |
| 5 mM | 0.4181 mL | 2.0903 mL | 4.1806 mL | 8.3612 mL | 10.4515 mL |
| 10 mM | 0.209 mL | 1.0452 mL | 2.0903 mL | 4.1806 mL | 5.2258 mL |
| 50 mM | 0.0418 mL | 0.209 mL | 0.4181 mL | 0.8361 mL | 1.0452 mL |
| 100 mM | 0.0209 mL | 0.1045 mL | 0.209 mL | 0.4181 mL | 0.5226 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice.[Pubmed:24009828]
Biomol Ther (Seoul). 2012 Jul;20(4):406-12.
This study was performed to examine the hepatoprotective effect of isorhamnetin-3-O-galactoside, a flavonoid glycoside isolated from Artemisia capillaris Thunberg (Compositae), against carbon tetrachloride (CCl4)-induced hepatic injury. Mice were treated intraperitoneally with vehicle or Isorhamnetin-3-O-galactoside (50, 100, and 200 mg/kg) 30 min before and 2 h after CCl4 (20 mul/kg) injection. Serum aminotransferase activities and hepatic level of malondialdehyde were significantly higher after CCl4 treatment, and these increases were attenuated by isorhamnetin-3-O-galactoside. CCl4 markedly increased serum tumor necrosis factor-alpha level, which was reduced by isorhamnetin-3-O-galactoside. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase- 2 (COX-2), and heme oxygenase-1 (HO-1) protein and their mRNA expression levels were significantly increased after CCl4 injection. The levels of HO-1 protein and mRNA expression levels were augmented by isorhamnetin-3-O-galactoside, while isorhamnetin- 3-O-galactoside attenuated the increases in iNOS and COX-2 protein and mRNA expression levels. CCl4 increased the level of phosphorylated c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38, and Isorhamnetin-3-O-galactoside reduced these increases. The nuclear translocation of nuclear factor kappa B (NF-kappaB), activating protein-1, and nuclear factor erythroid 2-related factor 2 (Nrf2) were signifi cantly increased after CCl4 administration. Isorhamnetin-3-O-galactoside attenuated the increases of NF-kappaB and c-Jun nuclear translocation, while it augmented the nuclear level of Nrf2. These results suggest that Isorhamnetin-3-O-galactoside ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways.
