Fmoc-Cys(tBu)-OHCAS# 67436-13-9 |
- PF-4708671
Catalog No.:BCC5031
CAS No.:1255517-76-0
- BIX 02565
Catalog No.:BCC4303
CAS No.:1311367-27-7
- BI-D1870
Catalog No.:BCC5030
CAS No.:501437-28-1
- CMK
Catalog No.:BCC1489
CAS No.:821794-90-5
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 67436-13-9 | SDF | Download SDF |
| PubChem ID | 100111 | Appearance | Powder |
| Formula | C22H25NO4S | M.Wt | 399.5 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 3-tert-butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid | ||
| SMILES | CC(C)(C)SCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13 | ||
| Standard InChIKey | IXAYZHCPEYTWHW-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Fmoc-Cys(tBu)-OH Dilution Calculator
Fmoc-Cys(tBu)-OH Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5031 mL | 12.5156 mL | 25.0313 mL | 50.0626 mL | 62.5782 mL |
| 5 mM | 0.5006 mL | 2.5031 mL | 5.0063 mL | 10.0125 mL | 12.5156 mL |
| 10 mM | 0.2503 mL | 1.2516 mL | 2.5031 mL | 5.0063 mL | 6.2578 mL |
| 50 mM | 0.0501 mL | 0.2503 mL | 0.5006 mL | 1.0013 mL | 1.2516 mL |
| 100 mM | 0.025 mL | 0.1252 mL | 0.2503 mL | 0.5006 mL | 0.6258 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Fmoc-Cys(tBu)-OH
- Isorhamnetin-3-O-galactoside
Catalog No.:BCC8190
CAS No.:6743-92-6
- (±)-Blebbistatin
Catalog No.:BCC7169
CAS No.:674289-55-5
- Z-D-His-OH
Catalog No.:BCC2767
CAS No.:67424-93-5
- 3-O-Acetyl-11-keto-beta-boswellic acid
Catalog No.:BCN1381
CAS No.:67416-61-9
- H-D-Lys-OMe.2HCl
Catalog No.:BCC2680
CAS No.:67396-08-1
- Drospirenone
Catalog No.:BCC4493
CAS No.:67392-87-4
- Catalposide
Catalog No.:BCN4225
CAS No.:6736-85-2
- Pterokaurane R
Catalog No.:BCN4076
CAS No.:67349-43-3
- (R,R)-Formoterol
Catalog No.:BCC1293
CAS No.:67346-49-0
- Hexa-D-arginine
Catalog No.:BCC6269
CAS No.:673202-67-0
- 1,3,5-Trihydroxyxanthone
Catalog No.:BCN3357
CAS No.:6732-85-0
- Kaurenoic acid
Catalog No.:BCN4600
CAS No.:6730-83-2
- Isoasatone A
Catalog No.:BCN7762
CAS No.:67451-73-4
- Amorolfine
Catalog No.:BCC8819
CAS No.:67467-83-8
- GBR 13069 dihydrochloride
Catalog No.:BCC6640
CAS No.:67469-45-8
- Vanoxerine
Catalog No.:BCC5130
CAS No.:67469-69-6
- GBR 12783 dihydrochloride
Catalog No.:BCC6676
CAS No.:67469-75-4
- Vanoxerine dihydrochloride
Catalog No.:BCC5129
CAS No.:67469-78-7
- GBR 12935 dihydrochloride
Catalog No.:BCC5380
CAS No.:67469-81-2
- DIDS
Catalog No.:BCC7942
CAS No.:67483-13-0
- Fuegin
Catalog No.:BCN5809
CAS No.:6750-10-3
- Eupatolide
Catalog No.:BCN7345
CAS No.:6750-25-0
- Arnidiol
Catalog No.:BCN3810
CAS No.:6750-30-7
- Spathulenol
Catalog No.:BCN4227
CAS No.:6750-60-3
A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile--the pharmacological importance of post-translational modifications.[Pubmed:24055806]
Peptides. 2013 Nov;49:145-58.
Cone snail venoms provide a largely untapped source of novel peptide drug leads. To enhance the discovery phase, a detailed comparative proteomic analysis was undertaken on milked venom from the mollusk-hunting cone snail, Conus textile, from three different geographic locations (Hawai'i, American Samoa and Australia's Great Barrier Reef). A novel milked venom conopeptide rich in post-translational modifications was discovered, characterized and named alpha-conotoxin TxIC. We assign this conopeptide to the 4/7 alpha-conotoxin family based on the peptide's sequence homology and cDNA pre-propeptide alignment. Pharmacologically, alpha-conotoxin TxIC demonstrates minimal activity on human acetylcholine receptor models (100 muM, <5% inhibition), compared to its high paralytic potency in invertebrates, PD50 = 34.2 nMol kg(-1). The non-post-translationally modified form, [Pro](2,8)[Glu](16)alpha-conotoxin TxIC, demonstrates differential selectivity for the alpha3beta2 isoform of the nicotinic acetylcholine receptor with maximal inhibition of 96% and an observed IC50 of 5.4 +/- 0.5 muM. Interestingly its comparative PD50 (3.6 muMol kg(-1)) in invertebrates was ~100 fold more than that of the native peptide. Differentiating alpha-conotoxin TxIC from other alpha-conotoxins is the high degree of post-translational modification (44% of residues). This includes the incorporation of gamma-carboxyglutamic acid, two moieties of 4-trans hydroxyproline, two disulfide bond linkages, and C-terminal amidation. These findings expand upon the known chemical diversity of alpha-conotoxins and illustrate a potential driver of toxin phyla-selectivity within Conus.
Acid-labile Cys-protecting groups for the Fmoc/tBu strategy: filling the gap.[Pubmed:23075170]
Org Lett. 2012 Nov 2;14(21):5472-5.
To address the existing gap in the current set of acid-labile Cys-protecting groups for the Fmoc/tBu strategy, diverse Fmoc-Cys(PG)-OH derivatives were prepared and incorporated into a model tripeptide to study their stability against TFA. S-Dpm proved to be compatible with the commonly used S-Trt group and was applied for the regioselecive construction of disulfide bonds.
Stereoselective Polymer-Supported Synthesis of Morpholine- and Thiomorpholine-3-carboxylic Acid Derivatives.[Pubmed:28085245]
ACS Comb Sci. 2017 Mar 13;19(3):173-180.
Herein we report the polymer-supported synthesis of 3,4-dihydro-2H-1,4-oxazine-3-carboxylic acid derivatives using immobilized Fmoc-Ser(tBu)-OH and Fmoc-Thr(tBu)-OH as the starting materials. After the solid-phase-synthesis of N-alkyl-N-sulfonyl/acyl intermediates, the target dihydrooxazines were obtained using trifluoroacetic acid-mediated cleavage from the resin. This approach was also studied for the preparation of dihydrothiazines from immobilized Fmoc-Cys(Trt)-OH. Inclusion of triethylsilane in the cleavage cocktail resulted in the stereoselective formation of the corresponding morpholine/thiomorpholine-3-carboxylic acids. Stereochemical studies revealed the specific configuration of the newly formed stereocenter and also the formation of stable N-acylmorpholine rotamers.
