Spathulenol

CAS# 6750-60-3

Spathulenol

Catalog No. BCN4227----Order now to get a substantial discount!

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Spathulenol: 5mg $374 In Stock
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Quality Control of Spathulenol

Number of papers citing our products

Chemical structure

Spathulenol

3D structure

Chemical Properties of Spathulenol

Cas No. 6750-60-3 SDF Download SDF
PubChem ID 92231 Appearance Powder
Formula C15H24O M.Wt 220.4
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1aR,4aR,7S,7aR,7bR)-1,1,7-trimethyl-4-methylidene-1a,2,3,4a,5,6,7a,7b-octahydrocyclopropa[h]azulen-7-ol
SMILES CC1(C2C1C3C(CCC3(C)O)C(=C)CC2)C
Standard InChIKey FRMCCTDTYSRUBE-BGPZULBFSA-N
Standard InChI InChI=1S/C15H24O/c1-9-5-6-11-13(14(11,2)3)12-10(9)7-8-15(12,4)16/h10-13,16H,1,5-8H2,2-4H3/t10-,11+,12+,13+,15-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Spathulenol

The herbs of Salvia sclarea

Biological Activity of Spathulenol

Description1. Spathulenol has immunomodulatory effect. 2. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway. 3. Spathulenol presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer and therefore is worthy for further in vivo studies.
TargetsP-gp | Caspase

Spathulenol Dilution Calculator

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Spathulenol Molarity Calculator

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Preparing Stock Solutions of Spathulenol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5372 mL 22.686 mL 45.3721 mL 90.7441 mL 113.4301 mL
5 mM 0.9074 mL 4.5372 mL 9.0744 mL 18.1488 mL 22.686 mL
10 mM 0.4537 mL 2.2686 mL 4.5372 mL 9.0744 mL 11.343 mL
50 mM 0.0907 mL 0.4537 mL 0.9074 mL 1.8149 mL 2.2686 mL
100 mM 0.0454 mL 0.2269 mL 0.4537 mL 0.9074 mL 1.1343 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Spathulenol

Identification of spathulenol in Salvia mirzayanii and the immunomodulatory effects.[Pubmed:20857430]

Phytother Res. 2011 Apr;25(4):557-62.

The methanol extract of Salvia mirzayanii has shown an immunomodulatory effect on peripheral blood lymphocytes. Bioassay-guided fractionation using a lymphocyte proliferation assay on Salvia mirzayanii was performed in order to purify and identify the active compounds. Fractionation of the methanol extract and purification of the components using normal column chromatography and preparative thin layer chromatography resulted in identification of the bioactive compound, Spathulenol, with an immunoinhibitory effect. Identification of this compound was performed by 1D and 2D NMR methods and HRMS. Treatment of activated lymphocytes with a concentrated fraction containing 62% of Spathulenol (SP) showed a decrease in the proliferation of lymphocytes with an IC(50) of 85.4 +/- 11.08 microg/mL. Flow cytometry analysis using annexin V and propidium iodide staining of the stimulated peripheral blood lymphocytes in the presence of SP demonstrated a dose dependent increase in the percentage of apoptotic cells (IC(50) ; 77.2 +/- 5.31 microg/mL). No significant increase in caspase 3 activity in a 20 h treatment of stimulated lymphocytes compared with the control was observed. In conclusion, this study identified the possible activity of Spathulenol as one of the immunomodulatory compounds present in Salvia mirzayanii. SP showed the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway.

Description

Spathulenol is isolated from Psidium guineense Sw, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1]

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