Home >> Research Area >>Coumarins>> 8'-Epicleomiscosin A

8'-Epicleomiscosin A

CAS# N/A

8'-Epicleomiscosin A

Catalog No. BCC3917----Order now to get a substantial discount!

Product Name & Size Price Stock
8'-Epicleomiscosin A: 5mg $104 In Stock
8'-Epicleomiscosin A: 10mg Please Inquire In Stock
8'-Epicleomiscosin A: 20mg Please Inquire Please Inquire
8'-Epicleomiscosin A: 50mg Please Inquire Please Inquire
8'-Epicleomiscosin A: 100mg Please Inquire Please Inquire
8'-Epicleomiscosin A: 200mg Please Inquire Please Inquire
8'-Epicleomiscosin A: 500mg Please Inquire Please Inquire
8'-Epicleomiscosin A: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of 8'-Epicleomiscosin A

Number of papers citing our products

Chemical structure

8'-Epicleomiscosin A

3D structure

Chemical Properties of 8'-Epicleomiscosin A

Cas No. N/A SDF Download SDF
PubChem ID 11200016 Appearance Powder
Formula C20H18O8 M.Wt 386.36
Type of Compound Coumarins Storage Desiccate at -20°C
Synonyms 8'-epi-cleomiscosin A
Solubility Soluble to 100 mM in DMSO and to 100 mM in ethanol
Chemical Name (2S,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one
SMILES COC1=C(C=CC(=C1)C2C(OC3=C4C(=CC(=C3O2)OC)C=CC(=O)O4)CO)O
Standard InChIKey OCBGWPJNUZMLCA-DOTOQJQBSA-N
Standard InChI InChI=1S/C20H18O8/c1-24-13-7-10(3-5-12(13)22)17-15(9-21)26-20-18-11(4-6-16(23)27-18)8-14(25-2)19(20)28-17/h3-8,15,17,21-22H,9H2,1-2H3/t15-,17+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 8'-Epicleomiscosin A

The herbs of Buxus sinica

Biological Activity of 8'-Epicleomiscosin A

Description8'-Epicleomiscosin A shows strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.

8'-Epicleomiscosin A Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

8'-Epicleomiscosin A Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of 8'-Epicleomiscosin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5883 mL 12.9413 mL 25.8826 mL 51.7652 mL 64.7065 mL
5 mM 0.5177 mL 2.5883 mL 5.1765 mL 10.353 mL 12.9413 mL
10 mM 0.2588 mL 1.2941 mL 2.5883 mL 5.1765 mL 6.4706 mL
50 mM 0.0518 mL 0.2588 mL 0.5177 mL 1.0353 mL 1.2941 mL
100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5177 mL 0.6471 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on 8'-Epicleomiscosin A

Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.

Chemical & Pharmaceutical Bulletin [2004, 52(12):1458-1461]

A new coumarinolignoid 8'-Epicleomiscosin A (1) together with the new glycoside 8-O-beta-D-glucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4-one (2) have been isolated from the aerial parts of Rhododendron collettianum and their structures determined on the basis of spectroscopic evidences. Tyrosinase inhibition study of these compounds and their structure-activity relationship (SAR) were also investigated. The compounds exhibited potent to mild inhibition activity against the enzyme. Especially, 8'-Epicleomiscosin A showed strong inhibition (IC50=1.33 microM) against the enzyme tyrosinase, as compared to the standard tyrosinase inhibitors kojic acid (IC50=16.67 microM) and L-mimosine (IC50=3.68 microM), indicating its potential used for the treatment of hyperpigmentation associated with the high production of melanocytes.

Keywords:

8'-Epicleomiscosin A,N/A,8'-epi-cleomiscosin A,Natural Products, buy 8'-Epicleomiscosin A , 8'-Epicleomiscosin A supplier , purchase 8'-Epicleomiscosin A , 8'-Epicleomiscosin A cost , 8'-Epicleomiscosin A manufacturer , order 8'-Epicleomiscosin A , high purity 8'-Epicleomiscosin A

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: