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Baicalein 7-O-beta-D-ethylglucuronide

CAS# 675624-38-1

Baicalein 7-O-beta-D-ethylglucuronide

2D Structure

Catalog No. BCN7981----Order now to get a substantial discount!

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Baicalein 7-O-beta-D-ethylglucuronide: 5mg Please Inquire In Stock
Baicalein 7-O-beta-D-ethylglucuronide: 10mg Please Inquire In Stock
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Baicalein 7-O-beta-D-ethylglucuronide: 50mg Please Inquire Please Inquire
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Quality Control of Baicalein 7-O-beta-D-ethylglucuronide

3D structure

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Baicalein 7-O-beta-D-ethylglucuronide

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Chemical Properties of Baicalein 7-O-beta-D-ethylglucuronide

Cas No. 675624-38-1 SDF Download SDF
PubChem ID 131676084 Appearance Powder
Formula C23H22O11 M.Wt 474.41
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name ethyl (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylate
SMILES CCOC(=O)C1C(C(C(C(O1)OC2=C(C(=C3C(=C2)OC(=CC3=O)C4=CC=CC=C4)O)O)O)O)O
Standard InChIKey RXRRNRCBAAZTNY-KHYDEXNFSA-N
Standard InChI InChI=1S/C23H22O11/c1-2-31-22(30)21-19(28)18(27)20(29)23(34-21)33-14-9-13-15(17(26)16(14)25)11(24)8-12(32-13)10-6-4-3-5-7-10/h3-9,18-21,23,25-29H,2H2,1H3/t18-,19-,20+,21-,23+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Baicalein 7-O-beta-D-ethylglucuronide

The root of Scutellaria baicalensis Georgi

Biological Activity of Baicalein 7-O-beta-D-ethylglucuronide

DescriptionBaicalein 7-O-beta-D-ethylglucuronide is a natural product from Scutellaria baicalensis Georgi.
In vitro

A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi.[Pubmed: 24995563 ]

Nat Prod Res. 2014;28(20):1772-6.


METHODS AND RESULTS:
A new flavone glycoside, wogonin 7-O-β-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-β-D-ethylglucuronide (Baicalein 7-O-beta-D-ethylglucuronide,2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-β-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses.
CONCLUSIONS:
Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 μM and 24.9 μM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 μM and 3.0 μM.

In vivo

Evaluation of wound healing activity of baicalein-7-O- β-Dglucuronide isolated from Leucas aspera[Reference: WebLink]

Journal of Applied Pharmaceutical Science, 2013, 3(12):46-51.

Leucas aspera (Willd.) Linn. (Lamiaceae), commonly known as "Thumbai," is distributed throughout India. This study includes the isolation and characterization of flavonoids present in Leucas aspera flowers were compared wound healing activity with standard soframycin ointment.
METHODS AND RESULTS:
The plant materials were extracted with 95% methanol, petroleum ether, ethyl acetate, and were subjected to column and TLC chromatographic separation analysis. The chemical constituents isolated from the flowers of L. aspera were characterized based on chemical tests and spectral analysis such as UV and NMR spectroscopy. The structure of the isolated compound was confirmed as baicalein-7-O- β-D-glucuronide (baicalin). It has been investigated for wound healing activity by applying on the albino rats. A slow rate of healing was observed earlier which turns to very rapid on the 12th day. The histopathological examination provided additional evidence for the experimental wound healing studies. Protease is a biochemical marker and pH measured to support the wound healing activity.
CONCLUSIONS:
We conclude that the baicalin isolated with the flowers of L. aspera has better wound healing activity.

Baicalein 7-O-beta-D-ethylglucuronide Dilution Calculator

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Preparing Stock Solutions of Baicalein 7-O-beta-D-ethylglucuronide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1079 mL 10.5394 mL 21.0788 mL 42.1576 mL 52.697 mL
5 mM 0.4216 mL 2.1079 mL 4.2158 mL 8.4315 mL 10.5394 mL
10 mM 0.2108 mL 1.0539 mL 2.1079 mL 4.2158 mL 5.2697 mL
50 mM 0.0422 mL 0.2108 mL 0.4216 mL 0.8432 mL 1.0539 mL
100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.4216 mL 0.527 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Baicalein 7-O-beta-D-ethylglucuronide

A new antioxidant flavone glycoside from Scutellaria baicalensis Georgi.[Pubmed:24995563]

Nat Prod Res. 2014;28(20):1772-6.

A new flavone glycoside, wogonin 7-O-beta-D-ethylglucuronide (1), together with a new natural flavone glycoside Baicalein 7-O-beta-D-ethylglucuronide (2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-beta-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses. Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 muM and 24.9 muM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 muM and 3.0 muM.

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