LinderalactoneCAS# 728-61-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 728-61-0 | SDF | Download SDF |
| PubChem ID | 6450191 | Appearance | Beige powder |
| Formula | C15H16O3 | M.Wt | 244.29 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 50 mg/mL (204.67 mM; Need ultrasonic) | ||
| SMILES | CC1=CCCC2=CC(C3=C(C1)OC=C3C)OC2=O | ||
| Standard InChIKey | LWCKQMHMTSRRAA-QGQQYVBWSA-N | ||
| Standard InChI | InChI=1S/C15H16O3/c1-9-4-3-5-11-7-13(18-15(11)16)14-10(2)8-17-12(14)6-9/h4,7-8,13H,3,5-6H2,1-2H3/b9-4+/t13-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Linderalactone shows hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with the EC(50) value of 98.0 microM. It shows significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, the IC50 is 8.48 microg/mL. |
| Targets | Immunology & Inflammation related |
| In vitro | Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.[Pubmed: 15702642]Nat Prod Res. 2005 Apr;19(3):283-6.
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| Structure Identification | J Nat Prod. 2009 Aug;72(8):1497-501.Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed: 19639966]
Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neoLinderalactone, and Linderalactone.
Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):765-7.Studies on constituents of the leaves of Lindera aggregata (Sims) Kosterm.[Pubmed: 12776349]To study the antibacterial and anti-inflammatory constituents of the leaves of Lindera aggrega.
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Linderalactone Dilution Calculator
Linderalactone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0935 mL | 20.4675 mL | 40.935 mL | 81.8699 mL | 102.3374 mL |
| 5 mM | 0.8187 mL | 4.0935 mL | 8.187 mL | 16.374 mL | 20.4675 mL |
| 10 mM | 0.4093 mL | 2.0467 mL | 4.0935 mL | 8.187 mL | 10.2337 mL |
| 50 mM | 0.0819 mL | 0.4093 mL | 0.8187 mL | 1.6374 mL | 2.0467 mL |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4093 mL | 0.8187 mL | 1.0234 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Anti-inflammatory furanogermacrane sesquiterpenes from Neolitsea parvigemma.[Pubmed:15702642]
Nat Prod Res. 2005 Apr;19(3):283-6.
Six furanogermacrane sesquiterpenes, pseudoneolinderane (1), Linderalactone (2), zeylanidine (3), zeylanicine (4), deacetylzeylanidine (5), and neolitrane (6), isolated from the stems of Neolitsea parvigemma, were tested for anti-inflammatory activities. Among them, 1 and 2 showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB. The IC50 of 1 and 2 were found to be 3.21 and 8.48 microg/mL, respectively.
[Studies on constituents of the leaves of Lindera aggregata (Sims) Kosterm].[Pubmed:12776349]
Zhongguo Zhong Yao Za Zhi. 2001 Nov;26(11):765-7.
OBJECTIVE: To study the antibacterial and anti-inflammatory constituents of the leaves of Lindera aggrega. METHOD: Compounds were isolated by colum chromatography, and the structures were identified by spectroscopic methods. RESULT: Six compounds were isolated and identified as mixture of 6-Acetyllindenanolide B-1 and B-2(I), dehydrolindestrenolide (II), hydroxylinderstrenolide (III), Linderalactone (IV), kameofero (V), beta-sitosterol (VI). CONCLUSION: These compounds were obtained from the leaves of Lindera aggregata for the first time.
Sesquiterpene lactones from the root tubers of Lindera aggregata.[Pubmed:19639966]
J Nat Prod. 2009 Aug;72(8):1497-501.
Phytochemical investigation of the root tubers of Lindera aggregata resulted in the isolation of five new sesquiterpene lactones, linderagalactones A-E (1-5), along with eight known sesquiterpenoids, 3-eudesmene-1beta,11-diol, hydroxylindestenolide, strychnistenolide, hydroxyisogermafurenolide, atractylenolide III, linderane, neoLinderalactone, and Linderalactone. The structures and relative configurations of 1-5 were determined by spectroscopic methods, especially HRESIMS and 2D NMR techniques. The absolute configurations of 1-4 were defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Linderagalactone A (1) is a halogenated sesquiterpene lactone possessing a unique rearranged carbon skeleton. Linderagalactone E (5), linderane, hydroxylindestenolide, and Linderalactone showed hepatoprotective activity against H2O2-induced oxidative damages on HepG2 cells with EC(50) values of 67.5, 167.0, 42.4, and 98.0 microM, respectively.
