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Magnolignan A

CAS# 93673-81-5

Magnolignan A

Catalog No. BCN4084----Order now to get a substantial discount!

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Quality Control of Magnolignan A

Number of papers citing our products

Chemical structure

Magnolignan A

3D structure

Chemical Properties of Magnolignan A

Cas No. 93673-81-5 SDF Download SDF
PubChem ID 11066525 Appearance Oil
Formula C18H20O4 M.Wt 300.4
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R)-3-[4-hydroxy-3-(2-hydroxy-5-prop-2-enylphenyl)phenyl]propane-1,2-diol
SMILES C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC(CO)O)O
Standard InChIKey ORPULAPYNPMMAQ-CQSZACIVSA-N
Standard InChI InChI=1S/C18H20O4/c1-2-3-12-4-6-17(21)15(9-12)16-10-13(5-7-18(16)22)8-14(20)11-19/h2,4-7,9-10,14,19-22H,1,3,8,11H2/t14-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Magnolignan A

The barks of Magnolia officinalis

Biological Activity of Magnolignan A

DescriptionMagnolignan A-2-O-beta-D-glucopyranoside has medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, and 46.4 microM, respectively.
In vitro

1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.[Pubmed: 18297743 ]

Magn Reson Chem. 2008 May;46(5):497-500.


METHODS AND RESULTS:
In our ongoing investigation of the bioactive constituents from plants, two new lignans, Magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol were isolated from heartwood of Streblus asper, along with three known lignans, Magnolignan A, magnolol, and magnaldehyde D. 1D and 2D NMR experiments, including COSY, HMQC, and HMBC, and other spectroscopic methods, including UV, IR, and MS were used for the determination of the structures and NMR assignments.
CONCLUSIONS:
Primary bioassays showed that Magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, 46.4 microM and 10.1 microM, 21.7 microM, respectively.

Protocol of Magnolignan A

Structure Identification
Natural Medicines, 1999 , 53 :1-4.

The simple method of distinction between Japanese and Chinese magnolia bark by ion-pair high-performance liquid chromatography using photodiode array detector[Reference: WebLink]

To establish a simple method for making distinction between Japanese and Chinese magnolia barks, the components in both magnolia barks were analysed by ion-pair high performance liquid chromatography using a photodiode array detector. Methyleugenol and Magnolignan A were detected only in Chinese magnolia barks. The presence or absence, of these components distinguishes Japanese magnolia barks from Chinese magnolia barks. The amounts these components in Chinese magnolia barks were determined.

Magnolignan A Dilution Calculator

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Magnolignan A Molarity Calculator

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Preparing Stock Solutions of Magnolignan A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3289 mL 16.6445 mL 33.2889 mL 66.5779 mL 83.2224 mL
5 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
10 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
50 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Magnolignan A

1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.[Pubmed:18297743]

Magn Reson Chem. 2008 May;46(5):497-500.

In our ongoing investigation of the bioactive constituents from plants, two new lignans, Magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol were isolated from heartwood of Streblus asper, along with three known lignans, Magnolignan A, magnolol, and magnaldehyde D. 1D and 2D NMR experiments, including COSY, HMQC, and HMBC, and other spectroscopic methods, including UV, IR, and MS were used for the determination of the structures and NMR assignments. Primary bioassays showed that Magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, 46.4 microM and 10.1 microM, 21.7 microM, respectively.

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