Dunnianol

CAS# 139726-29-7

Dunnianol

Catalog No. BCN6212----Order now to get a substantial discount!

Product Name & Size Price Stock
Dunnianol: 5mg $828 In Stock
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Quality Control of Dunnianol

Number of papers citing our products

Chemical structure

Dunnianol

3D structure

Chemical Properties of Dunnianol

Cas No. 139726-29-7 SDF Download SDF
PubChem ID 15714605 Appearance Powder
Formula C27H26O3 M.Wt 398.5
Type of Compound Lignans Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2,6-bis(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
SMILES C=CCC1=CC(=C(C=C1)O)C2=CC(=CC(=C2O)C3=C(C=CC(=C3)CC=C)O)CC=C
Standard InChIKey PLBCEMUNKQWXGZ-UHFFFAOYSA-N
Standard InChI InChI=1S/C27H26O3/c1-4-7-18-10-12-25(28)21(14-18)23-16-20(9-6-3)17-24(27(23)30)22-15-19(8-5-2)11-13-26(22)29/h4-6,10-17,28-30H,1-3,7-9H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dunnianol

The fruits of Illicium fargesii

Biological Activity of Dunnianol

DescriptionDunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold and decrease cellular oxidative stress by 40-65%, they show substantial activity against iNOS.
TargetsNF-kB | NOS | ROS
In vitro

Compounds from the bark of Illicium tsaii and their anti-inflammatory activity[Reference: WebLink]

Planta Med.,2014, 80(10):807-807.

Illicium tsaii is a Chinese native species growing in northwest China. The bark of I. tsaii, has been applied for the treatment of rheumatoid arthritis.
METHODS AND RESULTS:
Phytochemical investigation on this species resulted in the isolation and characterization of 28 compounds from the stem bark of I. tsaii. Structure determination was accomplished by means of spectroscopic data interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation such as NAG-1, NF-κB, iNOS and ROS. Sesquilignans showed significant activity, among which Dunnianol, macranthol and isoDunnianol increased NAG-1 activity 1.5 – 3.0 fold and decreased cellular oxidative stress by 40 – 65%.
CONCLUSIONS:
These three compounds showed substantial activity against iNOS, while only macranthol showed activity against NF-κB. This is the first study on the constituents of I. tsaii and evaluation of their biological activity.

Protocol of Dunnianol

Structure Identification
Synlett (Impact Factor: 2.46). 03/2010; 2010(04):633-635.

A Concise Synthesis of Dunnianol[Reference: WebLink]


METHODS AND RESULTS:
A short total synthesis of the neosesquilignan Dunnianol which features a double Suzuki cross-coupling as a key step is described.

Dunnianol Dilution Calculator

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Dunnianol Molarity Calculator

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Preparing Stock Solutions of Dunnianol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5094 mL 12.5471 mL 25.0941 mL 50.1882 mL 62.7353 mL
5 mM 0.5019 mL 2.5094 mL 5.0188 mL 10.0376 mL 12.5471 mL
10 mM 0.2509 mL 1.2547 mL 2.5094 mL 5.0188 mL 6.2735 mL
50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dunnianol

A Concise Synthesis of Dunnianol

Synlett (Impact Factor: 2.46). 03/2010; 2010(04):633-635.

A short total synthesis of the neosesquilignan Dunnianol which features a double Suzuki cross-coupling as a key step is described.

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