Palbinone

CAS# 139954-00-0

Palbinone

Catalog No. BCN3930----Order now to get a substantial discount!

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Quality Control of Palbinone

Number of papers citing our products

Chemical structure

Palbinone

3D structure

Chemical Properties of Palbinone

Cas No. 139954-00-0 SDF Download SDF
PubChem ID 192302 Appearance Orange powder
Formula C22H30O4 M.Wt 358.5
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3S,5R,9R,10S)-3,17-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-15,16-dione
SMILES CC1(C2CCC3(C(C2(CCC1O)C)C=CC4=C(C(=O)C(=O)C43C)O)C)C
Standard InChIKey KIAKLFLISZCITK-DUYCYYQJSA-N
Standard InChI InChI=1S/C22H30O4/c1-19(2)13-8-11-21(4)14(20(13,3)10-9-15(19)23)7-6-12-16(24)17(25)18(26)22(12,21)5/h6-7,13-15,23-24H,8-11H2,1-5H3/t13-,14+,15-,20-,21?,22?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Palbinone

The roots of Paeonia lactiflora Pall.

Biological Activity of Palbinone

Description1. Palbinone can induce HO-1 expression in the hepatic cells. 2. Palbinone shows a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol.
TargetsHO-1 | Nrf2 | PI3K | Akt | ERK | NADPH-oxidase

Palbinone Dilution Calculator

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Palbinone Molarity Calculator

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Preparing Stock Solutions of Palbinone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7894 mL 13.947 mL 27.894 mL 55.788 mL 69.735 mL
5 mM 0.5579 mL 2.7894 mL 5.5788 mL 11.1576 mL 13.947 mL
10 mM 0.2789 mL 1.3947 mL 2.7894 mL 5.5788 mL 6.9735 mL
50 mM 0.0558 mL 0.2789 mL 0.5579 mL 1.1158 mL 1.3947 mL
100 mM 0.0279 mL 0.1395 mL 0.2789 mL 0.5579 mL 0.6974 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Palbinone

Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha-hydroxysteroid dehydrogenase.[Pubmed:8477499]

Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90.

Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) of rat liver cytosol. The structures of Palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (1H-1H COSY, 1H-13C COSY, 1H-13C long-range COSY, and HMBC).

Palbinone from Paeonia suffruticosa protects hepatic cells via up-regulation of heme oxygenase-1.[Pubmed:23595773]

Phytother Res. 2014 Feb;28(2):308-11.

Paeonia suffruticosa has been traditionally employed for vitalizing blood circulation and alleviating liver and inflammatory diseases. The pathways by which Palbinone (PB) isolated from P. suffruticosa mediates heme oxygenase-1 (HO-1) induction were investigated using the specific inhibitors for PI3K and mitogen activated protein kinases pathways. The effect of PB-treatment on Nrf2 translocalization and HO-1-antioxidant response element (ARE) regulation was examined employing Western blot and luciferase assays. PB induced HO-1 expression via the activation of Nrf2 in the hepatic cells, and ARE-dependent genes were stimulated via the PB-mediated Nrf2 activation. PB-mediated HO-1 expression could be involved with PI3K/Akt and ERK1/2 pathways. Our study suggests the mechanism by which PB induces HO-1 expression in the hepatic cells. This might substantiate the traditional applications of P. suffruticosa for the treatment of oxidative stress-related diseases including oxidant and inflammatory-mediated vascular and liver diseases.

Description

Palbinone is a terpenoid isolated from the roots of Paeonia albiflora Pallas, potently inhibits 3α-hydroxysteroid dehydrogenase (3α-HSD), with an IC50 of 46 nM. Anti-inflammatory activity.

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