Manwuweizic acidCAS# 116963-87-2 |
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Number of papers citing our products
| Cas No. | 116963-87-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C30H46O4 | M.Wt | 470.68 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | (+)-Manwuweizic acid,Mawuweizic acid,3,4-Secolanosta-4(28),8,24-triene-3,26-dioic acid, (24Z)- | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Manwuweizic acid Dilution Calculator
Manwuweizic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1246 mL | 10.6229 mL | 21.2459 mL | 42.4917 mL | 53.1146 mL |
| 5 mM | 0.4249 mL | 2.1246 mL | 4.2492 mL | 8.4983 mL | 10.6229 mL |
| 10 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL | 4.2492 mL | 5.3115 mL |
| 50 mM | 0.0425 mL | 0.2125 mL | 0.4249 mL | 0.8498 mL | 1.0623 mL |
| 100 mM | 0.0212 mL | 0.1062 mL | 0.2125 mL | 0.4249 mL | 0.5311 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Synthesis of nigranoic acid and manwuweizic acid derivatives as HDAC inhibitors and anti-inflammatory agents.[Pubmed:33636436]
Bioorg Chem. 2021 Apr;109:104728.
As a successful anti-tumor drug target, the family of histone deacetylases (HDACs) is also a critical player in immune response, making the research of anti-inflammatory HDAC inhibitors an attractive new focus. In this report, triterpenoids nigranoic acid (NA) and Manwuweizic acid (MA) were identified as HDAC inhibitors through docking-based virtual screening and enzymatic activity assay. A series of derivatives of NA and MA were synthesized and assessed for their biological effects. As a result, hydroxamic acid derivatives of NA and MA showed moderately increased activity for HDAC1/2/4/6 inhibition (the lowest IC(50) against HDAC1 is 1.14 muM), with no activity against HDAC8. In J774A.1 macrophage, compound 1-3, 13 and 17-19 demonstrated inhibitory activity against lactate dehydrogenase (LDH) and IL-1beta production, without affecting cell viability. Compound 19 increased the histone acetylation level in J774A.1 cells, as well as inhibited IL-1beta maturation and caspase-1 cleavage. These results indicated that compound 19 blocks the activation of NLRP3 inflammasome, probably related to HDAC inhibition. This work provided a natural scaffold for developing low-cytotoxic and anti-inflammatory HDAC inhibitors, as well as a class of tool molecules for studying the relationship between HDACs and NLRP3 activation.
Triterpenoid acids from Schisandra propinqua with cytotoxic effect on rat luteal cells and human decidual cells in vitro.[Pubmed:11395273]
Fitoterapia. 2001 May;72(4):435-7.
Three triterpenoid acids, nigranoic acid (1), Manwuweizic acid (2), schisandronic acid (3), and other four compounds were isolated from the stems of Schisandra propinqua. Compounds 1 and 2 showed significant cytotoxic effect against human decidual cells and rat luteal cells in vitro.
