Mezlocillin SodiumCAS# 42057-22-7 |
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Quality Control & MSDS
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| Cas No. | 42057-22-7 | SDF | Download SDF |
| PubChem ID | 6335620 | Appearance | Powder |
| Formula | C21H25N5NaO8S2 | M.Wt | 562.6 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 31 mg/mL (55.20 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;sodium | ||
| SMILES | CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)NC(=O)N4CCN(C4=O)S(=O)(=O)C)C(=O)O)C.[Na] | ||
| Standard InChIKey | SGVORSZSYKDVFT-ZBJAFUORSA-N | ||
| Standard InChI | InChI=1S/C21H25N5O8S2.Na/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34;/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30);/t12-,13-,14+,17-;/m1./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Mezlocillin sodium is a broad-spectrum penicillin antibiotic. It is active against both Gram-negative and some Gram-positive bacteria. Target: Antibacterial Mezlocillin sodium is penicillin antibiotic, prescribed for certain types of bacterial infections. | |||||
Mezlocillin Sodium Dilution Calculator
Mezlocillin Sodium Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.7775 mL | 8.8873 mL | 17.7746 mL | 35.5492 mL | 44.4365 mL |
| 5 mM | 0.3555 mL | 1.7775 mL | 3.5549 mL | 7.1098 mL | 8.8873 mL |
| 10 mM | 0.1777 mL | 0.8887 mL | 1.7775 mL | 3.5549 mL | 4.4437 mL |
| 50 mM | 0.0355 mL | 0.1777 mL | 0.3555 mL | 0.711 mL | 0.8887 mL |
| 100 mM | 0.0178 mL | 0.0889 mL | 0.1777 mL | 0.3555 mL | 0.4444 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
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Stability of mezlocillin sodium as determined by high-performance liquid chromatography.[Pubmed:6663491]
J Pharm Sci. 1983 Dec;72(12):1479-81.
The stability of Mezlocillin Sodium solutions in water with either phosphate buffers or other ingredients used in intravenous admixtures (dextrose, fructose, and sodium chloride) has been studied using a stability-indicating high-performance liquid chromatographic method. This assay shows a relative standard deviation of 1.42% based on six injections. The optimum stability was shown at an approximate pH of 4.8, and solutions in dextrose (5%) and sodium chloride (0.9%) were stable for up to 4 days at 25 degrees, 36 days at 5 degrees, and for 60 days at -10 degrees. When refrigerated, the solutions in 5% fructose and 10% dextrose were as stable as those in 5% dextrose.
Microbiology, pharmacology, and clinical use of mezlocillin sodium.[Pubmed:6220263]
Pharmacotherapy. 1982 Nov-Dec;2(6):300-12.
The acylureido penicillin mezlocillin is active against gram-positive, gram-negative, and anaerobic bacteria. It easily penetrates the outer membrane of gram-negative bacteria, and it has a strong affinity for penicillin binding protein 3. Its stability to beta-lactamases is weak. Mezlocillin is synergistic when given in combination with aminoglycoside antibiotics. In pharmacokinetic studies mezlocillin conforms to a two compartment open model; its pharmacokinetic properties are dose-dependent. The half-life of the drug is about 1 hour after intravenous injection and 1.5 hours after intramuscular injection. Protein binding ranges from 16 to 42%, and 55% of a dose is excreted in the urine. Biliary excretion ranges from 0.5 to 25%. Clinical trial cure rates were as follows: bacteremia (78%), respiratory tract (62%), urinary tract (81%), gynecological (86%), bone and joint (55%), intraabdominal (67%) and skin and soft tissue (59%). The frequency of adverse reactions was 7.7%. Interstitial nephritis, CNS toxicity, and bleeding have not been reported.
