N-MethylarmepavineCAS# 74046-21-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 74046-21-2 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C20H26NO3+ | M.Wt | 328.4 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
N-Methylarmepavine Dilution Calculator
N-Methylarmepavine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0451 mL | 15.2253 mL | 30.4507 mL | 60.9013 mL | 76.1267 mL |
| 5 mM | 0.609 mL | 3.0451 mL | 6.0901 mL | 12.1803 mL | 15.2253 mL |
| 10 mM | 0.3045 mL | 1.5225 mL | 3.0451 mL | 6.0901 mL | 7.6127 mL |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.609 mL | 1.218 mL | 1.5225 mL |
| 100 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.609 mL | 0.7613 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Norditerpene and diterpene alkaloids from Aconitum variegatum.[Pubmed:15797610]
Phytochemistry. 2005 Apr;66(7):837-46.
Aerial parts of Aconitum variegatum L. from the Pyrenees furnished four norditerpene alkaloids, 16 beta-hydroxycardiopetaline, 8-ethoxysachaconitine, 14-acetylgenicunine B, N-deethyl-N-19-didehydrosachaconitine, five diterpene alkaloids 15-veratroyldictizine, 15-veratroyl-17-acetyldictizine, 15-veratroyl-17-acetyl-19-oxodictizine, N-ethyl-1 alpha-hydroxy-17-veratroyldictizine, variegatine and the known alkaloids sachaconitine, 14-O-acetylsachaconitine, karakoline, talatizamine, 10-hydroxytalatizamine, 14-acetyltalatizamine, 14-acetyl-10-hydroxytalatizamine, N-Methylarmepavine, pengshenin B, delsoline, dihydrodelsoline, delcosine and genicunin B. Structures of the alkaloids were established by MS, 1D- and 2D-NMR techniques.
[The synthesis and biological activity of substituted tetrahydroisoquinoline compounds].[Pubmed:1983058]
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Tetrandrine possesses calcium antagonistic and hypotensive effects. It was cleaved into two compounds O-methylcoclaurine (I) and N-Methylarmepavine (II) by Na/NH3. Pharmacological test indicated that I and II showed weaker calcium antagonistic activity but having alpha-adrenoceptor antagonistic effect. With I and II as lead compounds as well as integration of some structural feature of calcium antagonists and SAR of antiarrhythmic drugs, two kinds of substituted tetrahydroisoquinoline derivatives III, IV were designed and synthesized in order to search for novel cardiovascular drugs. Tetrahydroisoquinoline compounds were first synthesized by the Bischler-Napiraski cyclization with substituted phenethylamine and aromatic acetic acid or substituted cinnamic acid as starting materials. N-alkylsubstituted tetrahydroisoquinoline compounds were prepared by the reaction of 4 with alkyl halide to produce 5, then reduction of 5 by KBH4 to give III13-25. The synthesis of N-alkylaminoethyl substituted tetrahydroisoquinoline compounds involved the reaction of 6 with chloroacetyl chloride to obtain IV1-3, the reaction of IV1-3 with secondary amine to produce 9, and then reduction of 9 with LiA1H4 to give IV16-19. Preliminary tests showed that most of these compounds exhibited varied degree of alpha-adrenoceptor antagonistic effect, and some of them possess calcium antagonistic activity. In anesthetic normal rats III15, 19 showed certain degree of hypotensive effect. IV10, 11 exhibited significant protective effect on experimental arrhythmic animals. The results of quantum chemical calculation of some compounds demonstrate that the compounds might act with alpha 1-adrenoceptor by forming charge-transfer complex.
