Neridienone B

CAS# 61671-56-5

Neridienone B

Catalog No. BCN4143----Order now to get a substantial discount!

Product Name & Size Price Stock
Neridienone B: 5mg $799 In Stock
Neridienone B: 10mg Please Inquire In Stock
Neridienone B: 20mg Please Inquire Please Inquire
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Neridienone B: 200mg Please Inquire Please Inquire
Neridienone B: 500mg Please Inquire Please Inquire
Neridienone B: 1000mg Please Inquire Please Inquire

Quality Control of Neridienone B

Number of papers citing our products

Chemical structure

Neridienone B

3D structure

Chemical Properties of Neridienone B

Cas No. 61671-56-5 SDF Download SDF
PubChem ID 44418781 Appearance Powder
Formula C21H28O4 M.Wt 344.5
Type of Compound Steroids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (8R,9S,10R,13S,14S,17S)-17-[(1S)-1,2-dihydroxyethyl]-10,13-dimethyl-2,8,9,11,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,12-dione
SMILES CC12CCC(=O)C=C1C=CC3C2CC(=O)C4(C3CCC4C(CO)O)C
Standard InChIKey NCBLKWGLSQARQJ-BJSXQCTJSA-N
Standard InChI InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(24)11-22)21(15,2)19(25)10-17(14)20/h3-4,9,14-18,22,24H,5-8,10-11H2,1-2H3/t14-,15-,16+,17-,18+,20-,21-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Neridienone B

The herbs of Nerium indicum Mill.

Biological Activity of Neridienone B

Description1. Neridienone B has significant effects on calcein accumulation. 2. Neridienone exhibits significant leishmanicidal activity against amastigotes of L. mexicana.
TargetsAntifection

Neridienone B Dilution Calculator

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Neridienone B Molarity Calculator

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Preparing Stock Solutions of Neridienone B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9028 mL 14.5138 mL 29.0276 mL 58.0552 mL 72.5689 mL
5 mM 0.5806 mL 2.9028 mL 5.8055 mL 11.611 mL 14.5138 mL
10 mM 0.2903 mL 1.4514 mL 2.9028 mL 5.8055 mL 7.2569 mL
50 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.1611 mL 1.4514 mL
100 mM 0.029 mL 0.1451 mL 0.2903 mL 0.5806 mL 0.7257 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Neridienone B

Bioactive pregnanes from Nerium oleander.[Pubmed:17253842]

J Nat Prod. 2007 Jan;70(1):14-8.

Three new pregnanes, 21-hydroxypregna-4,6-diene-3,12,20-trione (1), 20R-hydroxypregna-4,6-diene-3,12-dione (2), and 16beta,17beta-epoxy-12beta-hydroxypregna-4,6-diene-3,20-dione (3), were isolated from Nerium oleander, together with two known compounds, 12beta-hydroxypregna-4,6,16-triene-3,20-dione (neridienone A, 4) and 20S,21-dihydroxypregna-4,6-diene-3,12-dione (Neridienone B, 5). The structures of compounds 1-3 were established on the basis of their spectroscopic data. The anti-inflammatory activity in vitro of compounds 2-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1), and compound 4 was active. The cytotoxic activity of compounds 1-5 was evaluated against four human cell lines, normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), human liver tumor cells (HepG2), and human lung carcinoma cells (A-549). Compound 4 showed significant cell growth inhibition of VA-13 and HepG2 cells. The MDR-reversal activity of compounds 1-5 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian cancer 2780AD cells in the presence of each compound. Compounds 1, 2, and 5 showed significant effects on calcein accumulation.

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