Neridienone BCAS# 61671-56-5 |
Quality Control & MSDS
3D structure
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| Cas No. | 61671-56-5 | SDF | Download SDF |
| PubChem ID | 44418781 | Appearance | Powder |
| Formula | C21H28O4 | M.Wt | 344.5 |
| Type of Compound | Steroids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (8R,9S,10R,13S,14S,17S)-17-[(1S)-1,2-dihydroxyethyl]-10,13-dimethyl-2,8,9,11,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,12-dione | ||
| SMILES | CC12CCC(=O)C=C1C=CC3C2CC(=O)C4(C3CCC4C(CO)O)C | ||
| Standard InChIKey | NCBLKWGLSQARQJ-BJSXQCTJSA-N | ||
| Standard InChI | InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(24)11-22)21(15,2)19(25)10-17(14)20/h3-4,9,14-18,22,24H,5-8,10-11H2,1-2H3/t14-,15-,16+,17-,18+,20-,21-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Nerium indicum Mill.
| Description | 1. Neridienone B has significant effects on calcein accumulation. 2. Neridienone exhibits significant leishmanicidal activity against amastigotes of L. mexicana. |
| Targets | Antifection |
Neridienone B Dilution Calculator
Neridienone B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9028 mL | 14.5138 mL | 29.0276 mL | 58.0552 mL | 72.5689 mL |
| 5 mM | 0.5806 mL | 2.9028 mL | 5.8055 mL | 11.611 mL | 14.5138 mL |
| 10 mM | 0.2903 mL | 1.4514 mL | 2.9028 mL | 5.8055 mL | 7.2569 mL |
| 50 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.1611 mL | 1.4514 mL |
| 100 mM | 0.029 mL | 0.1451 mL | 0.2903 mL | 0.5806 mL | 0.7257 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Bioactive pregnanes from Nerium oleander.[Pubmed:17253842]
J Nat Prod. 2007 Jan;70(1):14-8.
Three new pregnanes, 21-hydroxypregna-4,6-diene-3,12,20-trione (1), 20R-hydroxypregna-4,6-diene-3,12-dione (2), and 16beta,17beta-epoxy-12beta-hydroxypregna-4,6-diene-3,20-dione (3), were isolated from Nerium oleander, together with two known compounds, 12beta-hydroxypregna-4,6,16-triene-3,20-dione (neridienone A, 4) and 20S,21-dihydroxypregna-4,6-diene-3,12-dione (Neridienone B, 5). The structures of compounds 1-3 were established on the basis of their spectroscopic data. The anti-inflammatory activity in vitro of compounds 2-4 was examined on the basis of inhibitory activity against the induction of intercellular adhesion molecule-1 (ICAM-1), and compound 4 was active. The cytotoxic activity of compounds 1-5 was evaluated against four human cell lines, normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), human liver tumor cells (HepG2), and human lung carcinoma cells (A-549). Compound 4 showed significant cell growth inhibition of VA-13 and HepG2 cells. The MDR-reversal activity of compounds 1-5 was evaluated on the basis of the amount of calcein accumulated in MDR human ovarian cancer 2780AD cells in the presence of each compound. Compounds 1, 2, and 5 showed significant effects on calcein accumulation.
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