Norarmepavine

CAS# 3195-01-5

Norarmepavine

Catalog No. BCN7077----Order now to get a substantial discount!

Product Name & Size Price Stock
Norarmepavine: 5mg $828 In Stock
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Quality Control of Norarmepavine

Number of papers citing our products

Chemical structure

Norarmepavine

3D structure

Chemical Properties of Norarmepavine

Cas No. 3195-01-5 SDF Download SDF
PubChem ID 129317394 Appearance Powder
Formula C18H21NO3 M.Wt 299.37
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4-[[(1R)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl]methyl]phenol
SMILES COC1=C(C=C2C(CCC2=C1)CC3=CC=C(C=C3)O)OC
Standard InChIKey XFNBAZARFRWXTP-CYBMUJFWSA-N
Standard InChI InChI=1S/C18H20O3/c1-20-17-10-14-6-5-13(16(14)11-18(17)21-2)9-12-3-7-15(19)8-4-12/h3-4,7-8,10-11,13,19H,5-6,9H2,1-2H3/t13-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Norarmepavine

The stems of Nelumbo nucifera.

Biological Activity of Norarmepavine

Description1. N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. 2. D-(+)- N-norarmepavine exhibits significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. 3. Norarmepavine shows inhibition against Trypanosoma cruzi.
TargetsPAFR | Antifection

Norarmepavine Dilution Calculator

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Norarmepavine Molarity Calculator

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Preparing Stock Solutions of Norarmepavine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3403 mL 16.7017 mL 33.4035 mL 66.807 mL 83.5087 mL
5 mM 0.6681 mL 3.3403 mL 6.6807 mL 13.3614 mL 16.7017 mL
10 mM 0.334 mL 1.6702 mL 3.3403 mL 6.6807 mL 8.3509 mL
50 mM 0.0668 mL 0.334 mL 0.6681 mL 1.3361 mL 1.6702 mL
100 mM 0.0334 mL 0.167 mL 0.334 mL 0.6681 mL 0.8351 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Norarmepavine

Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro.[Pubmed:16981134]

Planta Med. 2006 Oct;72(13):1238-41.

Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-Norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.

[Cytotoxic alkaloids from stems of Nelumbo nucifera].[Pubmed:24791498]

Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(23):4104-8.

Chemical investigation was carried out to study the alkaloids from stems of Nelumbo nucifera and their cytotoxic activities. The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytotoxic activities by MTr method. Fifteen compounds were isolated from the total alkaloids extract and identified as asimilobine (1), isococlaurine (2), N-acetylNorarmepavine (3), crykonisine (4), velucryptine (5), pycnarrhine (6), liriodenine (7), nuciferine (8), nornuciferine (9), armepavine (10), N-methylasimilobine (11), coclaurine (12), N-Norarmepavine (13), N-methylcoclaurine (14) and lysicamine (15). Compounds 1-7 and 12-15 were isolated from stems of this plant for the first time, and compounds 2-6 were firstly isolated from the family Nelumbonaceae. Compounds 7-10, 13 and 14 showed significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.36%, 59.09%, 52.51%, 53.93%, 51.43%, and 64.31% at concentration of 1 x 10(-5) mol x L(-1), respectively.

Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi.[Pubmed:8061943]

Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Mar;107(3):367-71.

The alkaloids boldine, glaucine, predicentrine, apomorphine, coclaurine, Norarmepavine and codeine were tested against the epimastigotes of the Tulahuen and LQ strains and the DM 28c clone of Trypanosoma cruzi. The micromolar concentration to inhibit 50% of the culture growth (Tulahuen strain) for apomorphine, glaucine, predicentrine, boldine, Norarmepavine, coclaurine and codeine were 29, 90, 85, 110, 310, 580 and > 1000 respectively. Similar values were obtained with the LQ strain and the DM 28c clone. The most active compounds in inhibiting culture growth also inhibited cell respiration, suggesting that these drugs may act by blocking mitochondrial electron transport. The trypanocidal effects of these alkaloids appear to be correlated with their antioxidative activities.

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