Noreugenin

CAS# 1013-69-0

Noreugenin

2D Structure

Catalog No. BCN5827----Order now to get a substantial discount!

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Quality Control of Noreugenin

3D structure

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Noreugenin

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Chemical Properties of Noreugenin

Cas No. 1013-69-0 SDF Download SDF
PubChem ID 5375252 Appearance Powder
Formula C10H8O4 M.Wt 192.2
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility DMSO : 250 mg/mL (1300.93 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
Chemical Name 5,7-dihydroxy-2-methylchromen-4-one
SMILES CC1=CC(=O)C2=C(C=C(C=C2O1)O)O
Standard InChIKey NCUJRUDLFCGVOE-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H8O4/c1-5-2-7(12)10-8(13)3-6(11)4-9(10)14-5/h2-4,11,13H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Noreugenin

The rootbark of Schumanniophyton magnificum

Biological Activity of Noreugenin

In vitro

Chromone glycosides from Knoxia corymbosa.[Pubmed: 17135054]

J Asian Nat Prod Res. 2006 Oct-Nov;8(7):663-70.

Four new chromone glycosides, corymbosins K1-K4 (3-6), together with two known compounds, Noreugenin (1) and undulatoside A (2), were isolated from the whole plant of Knoxiacorymbosa (Rubiaceae).
METHODS AND RESULTS:
The structures of the new compounds were established through extensive NMR or X-ray spectroscopic analysis as 7-O-beta-D-allopyranosyl-5-hydroxy-2-methylchromone (corymbosin K1, 3), 7-O-beta-D-6-acetylglucopyranosyl-5-hydroxy-2-methylchromone (corymbosin K2, 4), 7-O-[6-O-(4-O-trans-caffeoyl-beta-D-allopyranosyl)]-beta-D-glucopyranosyl-5-hydroxy-2-methylchromone (corymbosin K3, 5) and 7-O-[6-O-(4-O-trans-feruloyl-beta-D-allopyranosyl)]-beta-D-glucopyranosyl-5-hydroxy-2- methylchromone (corymbosin K4, 6). Compounds 2-5 were subjected to test their immunomodulatory activity invitro.

Protocol of Noreugenin

Structure Identification
Planta Med. 1988 Jun;54(3):239-42.

New Chromone Alkaloids from the Stem Bark of Schumanniophyton magnificum.[Pubmed: 17265261]

Fractionation of a methanolic extract of the stem bark of SCHUMANNIOPHYTON MAGNIFICUM yielded large quantities of mannitol. In addition, Noreugenin and ten related chromone alkaloids were isolated. Seven of these alkaloids had been isolated previously from S. MAGNIFICUM and one other from S.PROBLEMATICUM but two of the alkaloids were novel, one was hydroxy- N-methylschumannificine and the other was the acetate of N-demethylrohitukine. The structures of the two alkaloids have been deduced from their spectral features.

Noreugenin Dilution Calculator

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Noreugenin Molarity Calculator

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Preparing Stock Solutions of Noreugenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.2029 mL 26.0146 mL 52.0291 mL 104.0583 mL 130.0728 mL
5 mM 1.0406 mL 5.2029 mL 10.4058 mL 20.8117 mL 26.0146 mL
10 mM 0.5203 mL 2.6015 mL 5.2029 mL 10.4058 mL 13.0073 mL
50 mM 0.1041 mL 0.5203 mL 1.0406 mL 2.0812 mL 2.6015 mL
100 mM 0.052 mL 0.2601 mL 0.5203 mL 1.0406 mL 1.3007 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Noreugenin

Chromone glycosides from Knoxia corymbosa.[Pubmed:17135054]

J Asian Nat Prod Res. 2006 Oct-Nov;8(7):663-70.

Four new chromone glycosides, corymbosins K1-K4 (3-6), together with two known compounds, Noreugenin (1) and undulatoside A (2), were isolated from the whole plant of Knoxiacorymbosa (Rubiaceae). The structures of the new compounds were established through extensive NMR or X-ray spectroscopic analysis as 7-O-beta-D-allopyranosyl-5-hydroxy-2-methylchromone (corymbosin K1, 3), 7-O-beta-D-6-acetylglucopyranosyl-5-hydroxy-2-methylchromone (corymbosin K2, 4), 7-O-[6-O-(4-O-trans-caffeoyl-beta-D-allopyranosyl)]-beta-D-glucopyranosyl-5-hydro xy-2-methylchromone (corymbosin K3, 5) and 7-O-[6-O-(4-O-trans-feruloyl-beta-D-allopyranosyl)]-beta-D-glucopyranosyl-5-hydro xy-2- methylchromone (corymbosin K4, 6). Compounds 2-5 were subjected to test their immunomodulatory activity invitro.

New Chromone Alkaloids from the Stem Bark of Schumanniophyton magnificum.[Pubmed:17265261]

Planta Med. 1988 Jun;54(3):239-42.

Fractionation of a methanolic extract of the stem bark of SCHUMANNIOPHYTON MAGNIFICUM yielded large quantities of mannitol. In addition, Noreugenin and ten related chromone alkaloids were isolated. Seven of these alkaloids had been isolated previously from S. MAGNIFICUM and one other from S.PROBLEMATICUM but two of the alkaloids were novel, one was hydroxy- N-methylschumannificine and the other was the acetate of N-demethylrohitukine. The structures of the two alkaloids have been deduced from their spectral features.

Description

Noreugenin, 5,7-dihydroxy-2-methyl-4H-chromen-4-one, is a new chromone from Hymenocallis littoralis Salisb. (Amaryllidaceae).

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