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Oxychelerythrine

CAS# 28342-33-8

Oxychelerythrine

Catalog No. BCN4864----Order now to get a substantial discount!

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Oxychelerythrine: 5mg $725 In Stock
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Quality Control of Oxychelerythrine

Number of papers citing our products

Chemical structure

Oxychelerythrine

3D structure

Chemical Properties of Oxychelerythrine

Cas No. 28342-33-8 SDF Download SDF
PubChem ID 147279 Appearance Powder
Formula C21H17NO5 M.Wt 363.4
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-13-one
SMILES CN1C2=C(C=CC3=CC4=C(C=C32)OCO4)C5=C(C1=O)C(=C(C=C5)OC)OC
Standard InChIKey IHTXRYTWDARUKX-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H17NO5/c1-22-19-13(5-4-11-8-16-17(9-14(11)19)27-10-26-16)12-6-7-15(24-2)20(25-3)18(12)21(22)23/h4-9H,10H2,1-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Oxychelerythrine

The herbs of Chelidonium majus

Biological Activity of Oxychelerythrine

Description1. Oxychelerythrine shows antifeeding activities against Tribolium castaneum adults, with the EC50 of 192.32 ppm. 2. Oxychelerythrine shows high modulatory activity enhancing the susceptibility of the S. aureus ATCC 6538 to all the tested antibiotics from two to four-fold.
TargetsAntifection

Oxychelerythrine Dilution Calculator

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Oxychelerythrine Molarity Calculator

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Preparing Stock Solutions of Oxychelerythrine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7518 mL 13.7589 mL 27.5179 mL 55.0358 mL 68.7947 mL
5 mM 0.5504 mL 2.7518 mL 5.5036 mL 11.0072 mL 13.7589 mL
10 mM 0.2752 mL 1.3759 mL 2.7518 mL 5.5036 mL 6.8795 mL
50 mM 0.055 mL 0.2752 mL 0.5504 mL 1.1007 mL 1.3759 mL
100 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.5504 mL 0.6879 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Oxychelerythrine

Synthesis of oxychelerythrine using lithiated toluamide-benzonitrile cycloaddition.[Pubmed:15635245]

Chem Pharm Bull (Tokyo). 2005 Jan;53(1):118-20.

Oxychelerythrine, benzo[c]phenanthridine alkaloid, was synthesized from easily available starting toluamide 5 and benzonitrile 6 using toluamide-benzonitrile cycloaddition reaction in 6 steps.

Enhancing activity of antibiotics against Staphylococcus aureus: Zanthoxylum capense constituents and derivatives.[Pubmed:25925969]

Phytomedicine. 2015 Apr 15;22(4):469-76.

Six compounds (1-6), isolated from the methanol extract of the roots of the African medicinal plant Zanthoxylum capense Thunb. (Rutaceae), and seven ester derivatives (7-13) were evaluated for their antibacterial activities and modulatory effects on the MIC of antibiotics (erythromycin, oxacillin, and tetracycline) and ethidium bromide (EtBr) against a Staphylococcus aureus reference strain (ATCC 6538). Using the same model, compounds 1-13 were also assessed for their potential as efflux pump inhibitors by a fluorometric assay that measures the accumulation of the broad range efflux pump substrate EtBr. Compounds 8 and 11 were further evaluated for their antibacterial, modulatory and EtBr accumulation effects against four additional S. aureus strains, which included two clinical methicillin-resistant S. aureus (MRSA) strains. Compounds (1-13) have not shown antibacterial activity at the concentration ranges tested. When evaluated against S. aureus ATCC 6538, Oxychelerythrine (1) a benzophenanthridine alkaloid, showed the highest modulatory activity enhancing the susceptibility of this strain to all the tested antibiotics from two to four-fold. Ailanthoidiol diacetate (8) and ailanthoidiol di-2-ethylbutanoate (11) were also good modulators when combined with EtBr, increasing the bacteria susceptibility by four and two-fold, respectively. In the EtBr accumulation assay, using ATCC 6538 strain, the phenylpropanoid (+)-ailanthoidiol (6) and most of its ester derivatives (8-11) exhibited higher activity than the positive control verapamil. The highest effects were found for compounds 8 and 11 that also increased the accumulation of EtBr, using S. aureus ATCC 25923 as model. Furthermore, both compounds (8, 11) were able to enhance the ciprofloxacin activity against the MRSA clinical strains tested, causing a reduction of the antibiotic MIC values from two to four-fold. The EtBr accumulation assay revealed that this modulation activity was not due to an inhibition of efflux pumps mechanism. These results suggested that Z. capense constituents may be valuable as leads for restoring antibiotic activity against MRSA strains.

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