Piperlotine ACAS# 389572-70-7 |
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| Cas No. | 389572-70-7 | SDF | Download SDF |
| PubChem ID | 773630 | Appearance | Powder |
| Formula | C14H17NO2 | M.Wt | 231.3 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-3-(4-methoxyphenyl)-1-pyrrolidin-1-ylprop-2-en-1-one | ||
| SMILES | COC1=CC=C(C=C1)C=CC(=O)N2CCCC2 | ||
| Standard InChIKey | JYEDISZKFNNREA-RMKNXTFCSA-N | ||
| Standard InChI | InChI=1S/C14H17NO2/c1-17-13-7-4-12(5-8-13)6-9-14(16)15-10-2-3-11-15/h4-9H,2-3,10-11H2,1H3/b9-6+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Piper nigrum L.
| Description | 1. Piperlotine A shows potent antiplatelet aggregation activity. |
| Targets | PAFR |
Piperlotine A Dilution Calculator
Piperlotine A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.3234 mL | 21.6169 mL | 43.2339 mL | 86.4678 mL | 108.0847 mL |
| 5 mM | 0.8647 mL | 4.3234 mL | 8.6468 mL | 17.2936 mL | 21.6169 mL |
| 10 mM | 0.4323 mL | 2.1617 mL | 4.3234 mL | 8.6468 mL | 10.8085 mL |
| 50 mM | 0.0865 mL | 0.4323 mL | 0.8647 mL | 1.7294 mL | 2.1617 mL |
| 100 mM | 0.0432 mL | 0.2162 mL | 0.4323 mL | 0.8647 mL | 1.0808 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot.[Pubmed:17941696]
J Agric Food Chem. 2007 Nov 14;55(23):9436-42.
The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, Piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds Piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.
Piperlotine A is an alkaloid isolated from Piper lolot, with potent antiplatelet aggregation activity.
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