Piperlotine A

CAS# 389572-70-7

Piperlotine A

Catalog No. BCN6481----Order now to get a substantial discount!

Product Name & Size Price Stock
Piperlotine A: 5mg $529 In Stock
Piperlotine A: 10mg Please Inquire In Stock
Piperlotine A: 20mg Please Inquire Please Inquire
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Quality Control of Piperlotine A

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Chemical structure

Piperlotine A

3D structure

Chemical Properties of Piperlotine A

Cas No. 389572-70-7 SDF Download SDF
PubChem ID 773630 Appearance Powder
Formula C14H17NO2 M.Wt 231.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-3-(4-methoxyphenyl)-1-pyrrolidin-1-ylprop-2-en-1-one
SMILES COC1=CC=C(C=C1)C=CC(=O)N2CCCC2
Standard InChIKey JYEDISZKFNNREA-RMKNXTFCSA-N
Standard InChI InChI=1S/C14H17NO2/c1-17-13-7-4-12(5-8-13)6-9-14(16)15-10-2-3-11-15/h4-9H,2-3,10-11H2,1H3/b9-6+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Piperlotine A

The herbs of Piper nigrum L.

Biological Activity of Piperlotine A

Description1. Piperlotine A shows potent antiplatelet aggregation activity.
TargetsPAFR

Piperlotine A Dilution Calculator

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Piperlotine A Molarity Calculator

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Preparing Stock Solutions of Piperlotine A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.3234 mL 21.6169 mL 43.2339 mL 86.4678 mL 108.0847 mL
5 mM 0.8647 mL 4.3234 mL 8.6468 mL 17.2936 mL 21.6169 mL
10 mM 0.4323 mL 2.1617 mL 4.3234 mL 8.6468 mL 10.8085 mL
50 mM 0.0865 mL 0.4323 mL 0.8647 mL 1.7294 mL 2.1617 mL
100 mM 0.0432 mL 0.2162 mL 0.4323 mL 0.8647 mL 1.0808 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Piperlotine A

Isolation and identification of antiplatelet aggregatory principles from the leaves of Piper lolot.[Pubmed:17941696]

J Agric Food Chem. 2007 Nov 14;55(23):9436-42.

The methanolic extract of Piper lolot, having shown potent inhibitory activity on platelet aggregation induced by arachidonic acid (AA) and platelet activating factor (PAF), was subjected to activity-guided isolation to yield twelve new amide alkaloids, Piperlotine A-L (1-12), along with twenty-nine known compounds. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were tested for their inhibitory activity on the rabbit platelet aggregation. The compounds Piperlotine A (1), piperlotine C (3), piperlotine D (4), piperlotine E (5), 3-phenyl-1-(2,4,6-trihydroxyphenyl)propan-1-one (21), 3-(4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one (22), 1-trans-cinnamoylpyrrolidine (24), sarmentine (26), pellitorine (27), methyl 3-phenylpropionate (32), and (10S)-10-hydroxypheophorbide a methyl ester (40) showed potent antiplatelet aggregation activity.

Description

Piperlotine A is an alkaloid isolated from Piper lolot, with potent antiplatelet aggregation activity.

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