1-CinnamoylpyrrolidineCAS# 52438-21-8 |
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| Cas No. | 52438-21-8 | SDF | Download SDF |
| PubChem ID | 765514 | Appearance | Powder |
| Formula | C13H15NO | M.Wt | 201.3 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (E)-3-phenyl-1-pyrrolidin-1-ylprop-2-en-1-one | ||
| SMILES | C1CCN(C1)C(=O)C=CC2=CC=CC=C2 | ||
| Standard InChIKey | JSIGICUAXLIURX-CMDGGOBGSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Piper nigrum
| Description | 1-Cinnamoylpyrrolidine shows inhibitory activity of platelet aggregation in vitro. |
| Targets | PAFR |
| In vitro | Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.[Pubmed: 15210155 ]Bioorg Med Chem. 2004 Jul 15;12(14):3885-9.
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1-Cinnamoylpyrrolidine Dilution Calculator
1-Cinnamoylpyrrolidine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.9677 mL | 24.8385 mL | 49.6771 mL | 99.3542 mL | 124.1927 mL |
| 5 mM | 0.9935 mL | 4.9677 mL | 9.9354 mL | 19.8708 mL | 24.8385 mL |
| 10 mM | 0.4968 mL | 2.4839 mL | 4.9677 mL | 9.9354 mL | 12.4193 mL |
| 50 mM | 0.0994 mL | 0.4968 mL | 0.9935 mL | 1.9871 mL | 2.4839 mL |
| 100 mM | 0.0497 mL | 0.2484 mL | 0.4968 mL | 0.9935 mL | 1.2419 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Phenolic acid amides: a new type of DNA strand scission agent from Piper caninum.[Pubmed:15210155]
Bioorg Med Chem. 2004 Jul 15;12(14):3885-9.
In a survey of the active components of crude plant extracts for their ability to cleave DNA, a crude extract prepared from Piper caninum was found to induce the relaxation of supercoiled pBR322 plasmid DNA in the presence of Cu(2+). Bioassay-guided fractionation was carried out on this extract, guided by an in vitro DNA strand scission assay. Three active principles were isolated and identified as N-cis-feruloyl tyramine (1),N-trans-feruloyl tyramine (2), and 1-Cinnamoylpyrrolidine (3). Compounds 1-3 represent a structurally new type of DNA strand scission agent.
1-Cinnamoylpyrrolidine (Compound 3), a crude extract prepared from Piper caninum, is a DNA strand scission agent, induces the relaxation of supercoiled pBR322 plasmid DNA. 1-Cinnamoylpyrrolidine (Compound 4) inhibits platelet aggregation induced by PAF with an IC50 of 37.3 μM.
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