Fraxidin

CAS# 525-21-3

Fraxidin

Catalog No. BCN5675----Order now to get a substantial discount!

Product Name & Size Price Stock
Fraxidin: 5mg Please Inquire In Stock
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Quality Control of Fraxidin

Number of papers citing our products

Chemical structure

Fraxidin

3D structure

Chemical Properties of Fraxidin

Cas No. 525-21-3 SDF Download SDF
PubChem ID 3083616 Appearance Powder
Formula C11H10O5 M.Wt 222.2
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 8-hydroxy-6,7-dimethoxychromen-2-one
SMILES COC1=C(C(=C2C(=C1)C=CC(=O)O2)O)OC
Standard InChIKey QNFBKOHHLAWWTC-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)9(13)11(7)15-2/h3-5,13H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Fraxidin

The herbs of Sarcandra glabra

Biological Activity of Fraxidin

In vitro

In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.[Pubmed: 10575381 ]

Planta Med. 1999 Oct;65(7):656-8.


METHODS AND RESULTS:
Bioassay-guided fractionation of an H2O extract of the barks of Fraxinus rhynchophylla has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, ferulaldehyde (1) and scopoletin (3) together with a coumarin, Fraxidin (2).
CONCLUSIONS:
Compounds 1 and 3 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was reflected in the decreased amount of iNOS protein, as determined by Western blotting.

Fraxidin Dilution Calculator

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Fraxidin Molarity Calculator

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Preparing Stock Solutions of Fraxidin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.5005 mL 22.5023 mL 45.0045 mL 90.009 mL 112.5113 mL
5 mM 0.9001 mL 4.5005 mL 9.0009 mL 18.0018 mL 22.5023 mL
10 mM 0.45 mL 2.2502 mL 4.5005 mL 9.0009 mL 11.2511 mL
50 mM 0.09 mL 0.45 mL 0.9001 mL 1.8002 mL 2.2502 mL
100 mM 0.045 mL 0.225 mL 0.45 mL 0.9001 mL 1.1251 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Fraxidin

In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.[Pubmed:10575381]

Planta Med. 1999 Oct;65(7):656-8.

Bioassay-guided fractionation of an H2O extract of the barks of Fraxinus rhynchophylla has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, ferulaldehyde (1) and scopoletin (3) together with a coumarin, Fraxidin (2). Compounds 1 and 3 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was reflected in the decreased amount of iNOS protein, as determined by Western blotting.

Description

Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.

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