FraxidinCAS# 525-21-3 |
Quality Control & MSDS
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| Cas No. | 525-21-3 | SDF | Download SDF |
| PubChem ID | 3083616 | Appearance | Powder |
| Formula | C11H10O5 | M.Wt | 222.2 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 8-hydroxy-6,7-dimethoxychromen-2-one | ||
| SMILES | COC1=C(C(=C2C(=C1)C=CC(=O)O2)O)OC | ||
| Standard InChIKey | QNFBKOHHLAWWTC-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C11H10O5/c1-14-7-5-6-3-4-8(12)16-10(6)9(13)11(7)15-2/h3-5,13H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Sarcandra glabra
| In vitro | In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.[Pubmed: 10575381 ]Planta Med. 1999 Oct;65(7):656-8.
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Fraxidin Dilution Calculator
Fraxidin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.5005 mL | 22.5023 mL | 45.0045 mL | 90.009 mL | 112.5113 mL |
| 5 mM | 0.9001 mL | 4.5005 mL | 9.0009 mL | 18.0018 mL | 22.5023 mL |
| 10 mM | 0.45 mL | 2.2502 mL | 4.5005 mL | 9.0009 mL | 11.2511 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.9001 mL | 1.8002 mL | 2.2502 mL |
| 100 mM | 0.045 mL | 0.225 mL | 0.45 mL | 0.9001 mL | 1.1251 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.[Pubmed:10575381]
Planta Med. 1999 Oct;65(7):656-8.
Bioassay-guided fractionation of an H2O extract of the barks of Fraxinus rhynchophylla has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, ferulaldehyde (1) and scopoletin (3) together with a coumarin, Fraxidin (2). Compounds 1 and 3 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was reflected in the decreased amount of iNOS protein, as determined by Western blotting.
Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.
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