CochlearineCAS# 52418-07-2 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 52418-07-2 | SDF | Download SDF |
| PubChem ID | 261618 | Appearance | Powder |
| Formula | C15H19NO3 | M.Wt | 261.32 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxybenzoate | ||
| SMILES | CN1C2CCC1CC(C2)OC(=O)C3=CC(=CC=C3)O | ||
| Standard InChIKey | OJADCNKLFKWRHJ-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H19NO3/c1-16-11-5-6-12(16)9-14(8-11)19-15(18)10-3-2-4-13(17)7-10/h2-4,7,11-12,14,17H,5-6,8-9H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Cochlearines A can significantly inhibit Cav3.1 T-type calcium channel (TTCC) and show noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels; and TTCC inhibitors hold great potential for the treatment of a variety of neurological disorders. |
| Targets | Calcium Channel |
Cochlearine Dilution Calculator
Cochlearine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8267 mL | 19.1336 mL | 38.2673 mL | 76.5345 mL | 95.6681 mL |
| 5 mM | 0.7653 mL | 3.8267 mL | 7.6535 mL | 15.3069 mL | 19.1336 mL |
| 10 mM | 0.3827 mL | 1.9134 mL | 3.8267 mL | 7.6535 mL | 9.5668 mL |
| 50 mM | 0.0765 mL | 0.3827 mL | 0.7653 mL | 1.5307 mL | 1.9134 mL |
| 100 mM | 0.0383 mL | 0.1913 mL | 0.3827 mL | 0.7653 mL | 0.9567 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.[Pubmed:26024438]
Org Lett. 2015 Jun 19;17(12):3082-5.
T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and Cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (+/-)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels.
Brassicaceae contain nortropane alkaloids.[Pubmed:16884746]
Phytochemistry. 2006 Sep;67(18):2050-7.
The report of Cochlearine, the 3-hydroxybenzoate ester of tropine found in Cochlearia officinalis, Brassicaceae, initiated a screening for tropane alkaloids in Cochlearia species and for calystegines in further Brassicaceae. All ten Cochlearia species investigated contained Cochlearine, tropine, and pseudotropine. Calystegines, nortropane alkaloids deriving from pseudotropine, were also identified in all Cochlearia species and accumulated up to 0.5% dry mass in leaves. Brassicaceae species of all major lineages of the family were analysed for calystegines. Of the 43 species included in the study, 18 accumulated calystegines of various structures. This is the first screening of Brassicaceae for products of the tropane alkaloid pathway, which is known as characteristic for plants of Solanaceae family. The identification of calystegines in all branches of the Brassicaceae family including Aethionema, a species at the basis of the family, suggests tropane alkaloids as secondary compound typical for Brassicaceae.
