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gamma-Fagarine

CAS# 524-15-2

gamma-Fagarine

Catalog No. BCN5673----Order now to get a substantial discount!

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Quality Control of gamma-Fagarine

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Chemical structure

gamma-Fagarine

3D structure

Chemical Properties of gamma-Fagarine

Cas No. 524-15-2 SDF Download SDF
PubChem ID 107936 Appearance Powder
Formula C13H11NO3 M.Wt 229.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 4,8-dimethoxyfuro[2,3-b]quinoline
SMILES COC1=CC=CC2=C1N=C3C(=C2OC)C=CO3
Standard InChIKey KFBCTNNQFGONHB-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H11NO3/c1-15-10-5-3-4-8-11(10)14-13-9(6-7-17-13)12(8)16-2/h3-7H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of gamma-Fagarine

The fruits of Zanthoxylum simulans Hance

Biological Activity of gamma-Fagarine

Description1. gamma-Fagarine possesses moderate levels of anti-HCV activities with IC₅₀ values being 20.4 ± 0.4 ug/ml, respectively. 2. gamma-Fagarine has sister chromatid exchanges (SCEs)-inducing activity, it induces SCEs in human lymphocyte cultures in a dose-dependent manner. 3. gamma-Fagarine and dictamnine are mutagenic in strain TA100 and TA98 with S9 mix, they have specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there are about 30-50 revertant colonies.
TargetsHCV

gamma-Fagarine Dilution Calculator

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gamma-Fagarine Molarity Calculator

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Preparing Stock Solutions of gamma-Fagarine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.363 mL 21.815 mL 43.63 mL 87.26 mL 109.075 mL
5 mM 0.8726 mL 4.363 mL 8.726 mL 17.452 mL 21.815 mL
10 mM 0.4363 mL 2.1815 mL 4.363 mL 8.726 mL 10.9075 mL
50 mM 0.0873 mL 0.4363 mL 0.8726 mL 1.7452 mL 2.1815 mL
100 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8726 mL 1.0908 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on gamma-Fagarine

Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.[Pubmed:25454460]

Fitoterapia. 2014 Dec;99:276-83.

Hepatitis C virus (HCV) infection is highly prevalent among global populations, with an estimated number of infected patients being 170 million. Approximately 70-80% of patients acutely infected with HCV will progress to chronic liver disease, such as liver cirrhosis and hepatocellular carcinoma, which is a substantial cause of morbidity and mortality worldwide. New therapies for HCV infection have been developed, however, the therapeutic efficacies still need to be improved. Medicinal plants are promising sources for antivirals against HCV. A variety of plants have been tested and proven to be beneficial as antiviral drug candidates against HCV. In this study, we examined extracts, their subfractions and isolated compounds of Ruta angustifolia leaves for antiviral activities against HCV in cell culture. We isolated six compounds, chalepin, scopoletin, gamma-Fagarine, arborinine, kokusaginine and pseudane IX. Among them, chalepin and pseudane IX showed strong anti-HCV activities with 50% inhibitory concentration (IC(5)(0)) of 1.7 +/- 0.5 and 1.4 +/- 0.2 mug/ml, respectively, without apparent cytotoxicity. Their anti-HCV activities were stronger than that of ribavirin (2.8 +/- 0.4 mug/ml), which has been widely used for the treatment of HCV infection. Mode-of-action analyses revealed that chalepin and pseudane IX inhibited HCV at the post-entry step and decreased the levels of HCV RNA replication and viral protein synthesis. We also observed that arborinine, kokusaginine and gamma-Fagarine possessed moderate levels of anti-HCV activities with IC(5)(0) values being 6.4 +/- 0.7, 6.4 +/- 1.6 and 20.4 +/- 0.4 mug/ml, respectively, whereas scopoletin did not exert significant anti-HCV activities at 30 mug/ml.

The SCE-inducing potency of the furoquinoline alkaloid, gamma-fagarine, and a gamma-fagarine-containing tincture from Rutae Herba, in cultured human lymphocytes.[Pubmed:2695761]

Mutagenesis. 1989 Nov;4(6):467-70.

gamma-Fagarine, a furoquinoline alkaloid naturally occurring in Rutae Herba induces sister chromatid exchanges (SCEs) in human lymphocyte cultures in a dose-dependent manner. The alkaloid is a direct-acting but weak SCE inducer. Similar direct but weak activity was detected in a sample of a commercial Rutae Tinctura which contained 68 micrograms/ml of gamma-Fagarine. The strong toxicity of the tincture makes it difficult to test a broader concentration range. There is some evidence that the SCE-inducing activity of the tincture is mainly due to the presence of gamma-Fagarine.

Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).[Pubmed:4069140]

Mutat Res. 1985 Dec;144(4):221-5.

A methanol extract of Dictamni Radicis Cortex exhibited a mutagenic effect on Salmonella typhimurium TA100 and TA98 with S9 mix. Two mutagenic compounds in Dictamni Radicis Cortex were isolated on a Sephadex LH 20 column and silica gel column chromatography and by preparative TLC. These were identified as dictamnine and gamma-Fagarine by UV, EI-Mass, 1H-NMR. Dictamnine and gamma-Fagarine were mutagenic in strain TA100 and TA98 with S9 mix. The dose-response curves were linear in the range 10-40 micrograms. Dictamnine and gamma-Fagarine had specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there were about 30-50 revertant colonies.

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