TetramethylcurcuminCAS# 52328-97-9 |
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| Cas No. | 52328-97-9 | SDF | Download SDF |
| PubChem ID | 11487078 | Appearance | Powder |
| Formula | C25H28O6 | M.Wt | 424.49 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione | ||
| SMILES | CC(C)(C(=O)C=CC1=CC(=C(C=C1)OC)OC)C(=O)C=CC2=CC(=C(C=C2)OC)OC | ||
| Standard InChIKey | VMMZAMVBGQWOHT-UTLPMFLDSA-N | ||
| Standard InChI | InChI=1S/C25H28O6/c1-25(2,23(26)13-9-17-7-11-19(28-3)21(15-17)30-5)24(27)14-10-18-8-12-20(29-4)22(16-18)31-6/h7-16H,1-6H3/b13-9+,14-10+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Tetramethylcurcumin is a natural product from Curcuma rcenyujin. |
| Structure Identification | J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 15;949-950:70-8.A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry.[Reference: WebLink]
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Tetramethylcurcumin Dilution Calculator
Tetramethylcurcumin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3558 mL | 11.7788 mL | 23.5577 mL | 47.1154 mL | 58.8942 mL |
| 5 mM | 0.4712 mL | 2.3558 mL | 4.7115 mL | 9.4231 mL | 11.7788 mL |
| 10 mM | 0.2356 mL | 1.1779 mL | 2.3558 mL | 4.7115 mL | 5.8894 mL |
| 50 mM | 0.0471 mL | 0.2356 mL | 0.4712 mL | 0.9423 mL | 1.1779 mL |
| 100 mM | 0.0236 mL | 0.1178 mL | 0.2356 mL | 0.4712 mL | 0.5889 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A high-throughput quantification method of curcuminoids and curcumin metabolites in human plasma via high-performance liquid chromatography/tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 15;949-950:70-8.
Recently, we characterized the mass spectra of curcumin, its two synthetic analogs Tetramethylcurcumin (TMC) and dimethylcyclohexyl curcumin (DMCHC), and its two metabolites tetrahydrocurcumin (THC) and curcumin O-glucuronide (COG) under a positive ion mode on a Thermo TSQ Quantum triple quadrupole mass spectrometer [9,10]. The protonated molecular ions are the predominant ions in their respective mass spectra; the major fragmentation pathway for curcumin, THC, TMC, and DMCHC is the cleavage of the heptenoid chain between the 3rd and the 4th carbon atoms (Scheme 1) [9]; and the major fragmentation for COG is glycosidic cleavage (Scheme 1) [10]. Two analytic methods for quantification of curcuminoids and COG [10] were established in both mouse and human plasma under a positive mode.
